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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Iranian Journal of Veterinary Surgery
- نوع مقاله: Journal Article
- کلمات کلیدی: Rat,Pseudomonas aeruginosa,Chitosan,WOUND HEALING,nano-CeO2
- چکیده:
- چکیده انگلیسی: Objective- The healing effect of chitosan supported cerium oxide nanoparticles (nano-CeO2) on cutaneous experimental excisional wound infected with pseudomonas aeruginosa was studied in rat.
Design- Experimental Study.
Animals- Sixty male albino rats.
Procedures- The chitosan supported nano-CeO2 hydrogel was prepared and characterized using Fourier-transform infrared spectroscopy (FT-IR), Energy Dispersive X-ray Spectroscopy (EDX), X-ray powder diffraction (XRD), Scanning Electron Microscopy (SEM) and Transmission Electron Microscopy (TEM). The wound was infected with p. aeruginosa and in positive control (PC) group it was treated with silver sulfadiazine ointment with no treatment in negative control (NC) group. The infected wound was treated with chitosan suspension-gel, cerium oxide nanoparticles solution or chitosan supported-CeO2 nanoparticle gel in the treatment groups. The rats were randomized into five groups (n=12). Each group was subdivided into three subgroups of four animals each and studied 3, 7 and 14 days post-wounding.
Results- Plantimetry, histopathological assessments and hydroxyprolin content showed better and faster healing of the wounds in the treatment groups, particularly in chitosan supported-CeO2 nanoparticle gel (ChCe) group compared to the NC group (P< 0.05). Using by Ferric Reducing Antioxidant Power (FRAP) the total antioxidant capacity was statistically higher in treatment groups compared to NC group (p< 0.05). The bacterial numbers were significantly lower in ChCe and cerium oxide nanoparticles solution (Ce) groups compared to chitosan (CH) group on day 3 post-wounding (P< 0.05).
Conclusion and Clinical Relevance-Topical application of the chitosan supported nano-CeO2 particles on the infected wound enhanced tissue total antioxidant capacity, reduced the bacterial count, accelerated proliferation and migration of fibroblasts and keratinocytes, increased hydroxyproline level and neovascularization scale of the healing wound. Chitosan supported nano-CeO2 hydrogel could be suggested as an alternative therapy for treating of the infected wound.- انتشار مقاله: 15-05-1396
- نویسندگان: Ako Shabrandi,Saeed Azizi,Rahim Hobbenaghi,Abdolghafar Ownagh,Sajjad Keshipour
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Chemistry and Chemical Engineering
- نوع مقاله: Journal Article
- کلمات کلیدی: Esterification,Polyol Esters,Diesters, SnO2, Nanoparticles
- چکیده:
- چکیده انگلیسی: Esterification reactions of some polyols and diols were investigated in the presence of SnO2 and nano-SnO2 and the results were compared with the catalyst-free conditions. High conversions were obtained for most of the reactions in the presence of SnO2 and nano-SnO2 which shows the high catalytic activity of SnO2 and nano-SnO2 for the esterification reaction. Low cost of the catalysts compared to alkyl tins, high safety compared to protic acids such as sulfuric acid and high chemical and thermal stability of the catalysts make the reactions interesting for the large-scale production of various polyol esters. Due to the important role of the polyol esters in various industries especially in the lubricant industry, the introduced approach can be interesting.
- انتشار مقاله: 09-07-1396
- نویسندگان: Sajjad Keshipour,Maryam Houshyar,Zahra Fatemi
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Chemistry and Chemical Engineering
- نوع مقاله: Journal Article
- کلمات کلیدی: Reduction,nitroaromatics,heterogeneous catalyst,bimetallic,Cobalt,Cellulose,Palladium
- چکیده:
- چکیده انگلیسی: Pd and Co nanoparticles were deposited on cellulose for use as a heterogeneous catalyst in the bimetallic catalytic reduction reaction. The catalyst was characterized with Energy Dispersive X-Ray Spectroscopy, X-Ray Diffraction pattern, Thermal Gravimetric Analysis, Flame Atomic Absorption Spectroscopy, and Transmission Electron Microscopy, and applied in the reduction reaction of nitroaromatics using NaBH4 at room temperature. Aromatic amines were obtained as the sole product of the reduction reaction during 2h. This reaction has some advantages such as mild reaction conditions, high yield, green solvent, and recyclable catalyst. Also, the recovered catalyst is applicable in the reduction reaction for 4 times without a significant decrease in the activity.
- انتشار مقاله: 29-06-1395
- نویسندگان: Sajjad Keshipour,Kamran Adak
- مشاهده
- جایگاه : پژوهشی
- مجله: Advances in Environmental Technology
- نوع مقاله: Journal Article
- کلمات کلیدی: Chitosan,Reduction,nitroaromatics,heterogeneous catalyst,bimetallic
- چکیده:
- چکیده انگلیسی: A new bimetallic nanocomposite of chitosan was prepared. Pd and Co nanoparticles were deposited on chitosan to produce a new heterogeneous recyclable catalyst for use in the bimetallic catalytic reduction reaction. The catalyst was characterized with common analysis methods for nanocomposites including Energy Dispersive X-Ray Spectroscopy, X-Ray Diffraction pattern, Thermal Gravimetric Analysis, Flame Atomic Absorption Spectroscopy and Scanning Electron Microscopy, and applied in the reduction reaction of nitroaromatics using NaBH4 at room temperature. The bimetallic system gave good results compared to each of the applied metals. Various aromatic amines and diamines were used in the reduction reaction. The aromatic amines were obtained as the sole product of the reduction reaction with 15 mol% Pd and 12 mol% Co during 2h. This reaction had some advantages such as mild reaction conditions, high yield, green solvent, and a recyclable catalyst. Also, the recovered catalyst was applicable in the reduction reaction without a significant decrease in the activity for up to six times.
- انتشار مقاله: 05-12-1395
- نویسندگان: Sajjad Keshipour,Seyyedeh Sahra Mirmasoudi
- مشاهده