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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Iranian Journal of Pharmaceutical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: Cytotoxicity,Radiopharmaceutical,Brine shrimp,bis-Thiosemicar bazones
- چکیده:
- چکیده انگلیسی: In the present study, aqueous solutions of some copper-complexing ligands were screened for their cytotoxicity using brine shrimp lethality test. Among the ligands tested, diacetyl-bis(N4-methylthiosemicarbazones) (ATSM) proved to be the most safe and non-toxic compound (2% lethality at 10 ppm), while pyruvaldehyde Bis(N4-methyl)thiosemicarbazone (PTSM) was shown to possess low toxicity (7% lethality at 10 ppm) and glyoxal-bis-thiosemicarbazone (GTS) proved to be a toxic compound even at 1 ppm (20% lethality). An interesting structure-toxicity relationship was observed for the ligands based on their water solubility leading to more toxicity which can be related to polysaccharide crustae of the shrimps. Considering the 1-10 ppm to be the maximum possible concentration of the ligands in the final pharmaceutical samples, the safety of these ligands are ATSM>PTSM>GTS.
- انتشار مقاله: 13-11-1390
- نویسندگان: Amir Reza Jalilian,Aytak Novinrooz,Sahar Sadraee,Marzieh Heydarieh,Mehdi Akhlaghi
- مشاهده