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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Iranian Journal of Pathology
- نوع مقاله: Journal Article
- کلمات کلیدی: Lung cancer,Mutation,Iranian,EGFR Genes
- چکیده:
- چکیده انگلیسی: Background and Objective: Epidermal growth factor receptor (EGFR) gene mutation, especially in exons 18 to 21, is an important predictor of the response rate of lung adenocarcinoma to tyrosine kinase inhibitors. There are variable reports from Asian and European countries, as well as North America, about the frequency of the EGFR mutation in lung adenocarcinoma, yet molecular study about this incidence has been published from Iran. In this study, we investigated the frequency of this mutation in our center, which is the largest referral center in the south of country. This report will be the first published article about EGFR mutational analysis from Iran.
Methods: During the study period (September 2011 till September 2016) i.e. 5 years, there have been 50 cases of pathologically-confirmed lung adenocarcinoma. These cases underwent mutational analysis for exons 18 to 21 of the EGFR gene by PCR and DNA sequencing. All demographic findings were also extracted from the patients’ charts and recorded.
Results: There were 30 male and 20 female patients, with an average age of 58 years. The overall frequency of EGFR mutation was 28% (14 out of 50). The most common mutation was Del 19 (10 of 14, 71.4%), 3 mutations were found in exon 20 and one mutation was found in exon 21. EGFR mutations were more frequent in women than in men (30% versus 26.7%) and in nonsmokers than in smokers (37.9% versus 14.3%).
Conclusion: Lung adenocarcinoma with EGFR mutation shows strong association with female non-smokers. Our results showed an intermediate frequency of this mutation, which was higher than results from Western countries and lower than most Asian countries.- انتشار مقاله: 04-04-1396
- نویسندگان: Sahand Mohammadzadeh,Zahra Jowkar,Mitra Mirzaee,Bita Geramizadeh
- مشاهده
- جایگاه : پژوهشی
- مجله: Annals of Colorectal Research
- نوع مقاله: Journal Article
- کلمات کلیدی: Eosinophilic cholecystitis,Gallbladder disease,Cholecystectomy
- چکیده:
- چکیده انگلیسی: The clinical presentation of eosinophilic cholecystitis (EC) is similar to that of typical cholecystitis, and its common symptoms are right upper quadrant (RUQ) tenderness and Murphy’s sign. In the literature, some reported cases have been associated with the hyper-eosinophilic syndrome(HES), infections, drugs, and parasitosis; however, its etiology has often been unknown.
We report a 32-year-old woman presented with two-day RUQ pains and radiation to the right shoulder. A clinical picture of severe acute cholecystitis was recorded, and the patient underwent open cholecystectomy. Microscopically, we observed an edematous wall with occasional acute and chronic inflammatory cells and predominantly eosinophils. Due to peripheral eosinophilia, we recommended the patient to be examined for the hyper-eosinophilic syndrome, eosinophilic gastroenteritis, and parasitosis. In follow up, parasitic gastroenteritis was diagnosed, and the patent underwent proper treatment.
Since the EC signs are similar to those of typical cholecystitis, it should not be considered a separate entity. The significance of the EC diagnosis is that it can be associated with other diseases, and this should be considered when it is diagnosed.- انتشار مقاله: 25-05-1399
- نویسندگان: Nasim Matani,Neda Soleimani,Sahand Mohammadzadeh
- مشاهده
- جایگاه : پژوهشی
- مجله: Annals of Colorectal Research
- نوع مقاله: Journal Article
- کلمات کلیدی: Acute Appendicitis,Appendix,Trichobezoar
- چکیده:
- چکیده انگلیسی: case report
abstract
Introduction:
Acute appendicitis is usually developing due obstruction of appendix and is one of the most common emergency surgical cases. Many factors are involved in the etiology like fecalith, stricture, foreign body, worm infestation and neoplasm [1]. Among causes of acute appendicitis foreign body is more frequent in children compared to adults. Various types of foreign bodies may obstruct the appendix lumen and cause acute appendicitis but most of foreign bodies generally do not cause any complication and pass spontaneously [2].
Trichobezoar is made of hair which become hard, like a mass and usually found in stomach.- انتشار مقاله: 01-05-1398
- نویسندگان: Masoud Hosseinzadeh,Sahand Mohammadzadeh
- مشاهده