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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Trends in Pharmaceutical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: Mitochondria,weakness,Cirrhosis,Cell death,Energy crisis,Muscle waste
- چکیده:
- چکیده انگلیسی: Cirrhosis-associated muscle mass loss or sarcopenia is a common complication (17-30% prevalence) in cirrhotic patients. However, the pathogenesis of this complication is poorly understood. Therefore, finding the mechanisms of sarcopenia could lead to the development of therapeutic strategies against this complication. In the current study, rats underwent bile duct ligation (BDL) surgery, and their skeletal muscle (gastrocnemius; GS) was isolated and assessed 28 and 56 days after BDL operation. Significant increase in biomarkers of oxidative stress, including reactive oxygen species (ROS) formation, lipid peroxidation, and increased oxidized glutathione (GSSG) levels were detected in the muscle of cirrhotic animals. Skeletal muscle tissue antioxidant capacity and reduced glutathione (GSH) were also significantly decreased in BDL rats. Moreover, deterioration of several mitochondrial indices, including mitochondrial depolarization, increased mitochondrial permeabilization, depleted ATP reservoirs, and decreased mitochondrial dehydrogenases activity, were evident in the GS isolated from cirrhotic rats. Based on these data, oxidative stress and mitochondrial impairment seem to play as primary mechanisms of cirrhosis-induced sarcopenia.
- انتشار مقاله: 15-05-1399
- نویسندگان: Omid Farshad,Mohammad Mehdi Ommati,Jale Yüzügülen,Sahand Alizadeh,Khadijeh Mousavi,Negar Azarpira,Anahita Marhonian,Akram Jamshidzadeh,Reza Heidari
- مشاهده
- جایگاه : پژوهشی
- مجله: Computational Engineering and Physical Modeling
- نوع مقاله: Journal Article
- کلمات کلیدی: Traffic,Transportation,Traffic Signs,guidance signs
- چکیده:
- چکیده انگلیسی: Traffic signs are one of the essentials of roads around the world. While drivers are using them appropriately and take carefully concentrate on them, it’s reduces significant road accidents, which it's would depend on human characters. Therefore, in this research, a statistical population of 768 drivers in various categories had been investigated. All kinds of traffic signs such as informative, disciplinary, & route guidance signs were discussed in their corresponding categories. Questions about understanding, recognition and familiarity with signs were asked from 768 participants. The current problems with traffic signs were identified according to answered questions. This procedure was helpful for understanding and getting more familiar with different groups of traffic signs, so the most understandable type of traffic signs was identified. We evaluated drivers’ ability to recognize traffic signs by means of a special questionnaire, so different types of traffic signs were investigated according to their understandability. In order to perform our analysis, various groups of drivers were classified based on their age, education level, driving experience, gender. The collected answers were analyzed by statistical methods in SPSS software. According to the acquired results, it was proved that there is a direct relationship between education level and the ability to recognize traffic signs. On the other hand, there is an inverse relationship between driving experience and recognition of various traffic signs. The estimated Pearson correlation coefficient for respondents’ right-wrong answers with respect to education level is 0.56. It means that the higher the education level, the higher the percentage of right answers.
- انتشار مقاله: 03-11-1398
- نویسندگان: Sahand Alizadeh,Amir Ismail Frohid
- مشاهده