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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Journal of Kerman University of Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: cancer,Stem Cell,Review Study
- چکیده:
- چکیده انگلیسی: The presence of stem cells in leukemia and solid tumors has been demonstrated in recent decades. Cancer stem cells have the potency of tumorigenesis; furthermore, they have the ability of self-renewing and differentiation like other stem cells. They also play important role in the process of tumor invasion and metastasis. Several studies have been performed to discover the specific markers and different phenotypes of these cells that can be very important in their identification. It seems that the characteristic of cancer stem cells, like tumor genesis, is greatly related to the specific signaling pathways such as Wnt, β catenin and hedgehog. In addition, the tumor microenvironment and its controlling agents are the important factors involving in the regulation of cancer stem cell function. The present review aimed to investigate the biology of cancer stem cells, specific signaling pathways, factors controlling the microenvironment as well as the role of microRNAs in controlling the function of these cells to provide new therapeutic methods.
- انتشار مقاله: 21-01-1394
- نویسندگان: Hamid Khodayari,Reyhaneh Chamani,Saeed Khodayari,Ali Mohammad Alizadeh
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Iran,Hospital,Predicting,Inpatient length of stay
- چکیده:
- چکیده انگلیسی: Objective: The length of stay is an important indicator of hospital performance and efficiency. Regarding the importance of the length of stay, this study aimed to design a structural model of the inpatients’ length of stay in the educational and therapeutic health care facilities of Iran in order to identify the influencing dimensions. Methods: The present study was an analytical and applied study. The face validity of the data gathering tool was investigated by the expert judgment and the construct validity was examined by using the exploratory factor analysis. In order to verify the reliability of the tool, the internal consistency was also trialed by using the Cronbach’s alpha. For ranking the influencing dimensions and factors and also in order to examine the causal relationships between the variables in a coherent manner and presenting the final model, the structural equation modeling technique was used in AMOS software at a significant level of 0.05. Results: The mentioned structural model consists of 4 dimensions and 29 factors influencing the length of stay of hospitalized patients. The independent variables are based on priority and importance as follows: patients’ conditions, the underlying factors, the clinical staff performance, and hospitals’ service delivery, which were examined by second-order factor analysis in order to study the relationship between them and the inpatients’ length of stay. Conclusion: Considering the importance of each one of the proposed dimensions from the point of view of service providers in some therapeutic centers of the country by paying attention to the role of each one of them in preventing prolonged hospitalization can be essential in the effectiveness of the treatment and cost reduction.
- انتشار مقاله: 22-10-1398
- نویسندگان: Omid Khosravizadeh,Soudabeh Vatankhah,Mina Jahanpour,Negar Yousefzadeh,Saeed Shahsavari,Saeed Yari
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Meta-Analysis,occupational exposure,Occupational cancer,Radar,neoplasm
- چکیده:
- چکیده انگلیسی: Objective: Microwave radiation is one of the most growing environmental workplace factors that exposes too many workers in the various workplaces. Regard to concerns about cancer incidence in these workers and lack of systematic or meta-analytic studies about this object, so, we conducted a meta-analysis to acquire an understanding of the association between cancer risk and occupational exposure to radar radiation. Methods: A systematic search was carried out on case-control, cohort and clinical control trial studies that published in the Cochrane Library, PubMed, ISI Web of Science, Scopus and Google scholar databases that accomplished from March 2017 to March 2018 and updated on 30 September, 2018 in English and Persian articles without time limit in publication date. Keywords were selected based on PICO principle and collected from MeSH database. After removal of duplicated studied, taking into inclusion and exclusion criteria, the process of screening was carried out and data were extracted after preparation of the full text of included articles. Article collection was completed by manually searching for a reference list of eligible studies. For quality assessment of included studies, Newcastle-Ottawa scale was used. Results: a total of 533 studies was found in the first step of literature search, only 6 were included with 53,008 sample size according to inclusion and exclusion criteria. Estimated pooled random effects size analysis showed no significant increasing effect of occupational exposure to radar radiation on mortality rate (MR=0.81, 95%CI: 0.78, 0.83) and relative risk (RR=0.87, 95%CI: 0.75, 0.99, P <0.0001) of cancer with a significant heterogeneity between the selected studies. Conclusions: In conclusion, the results of this meta-analysis study have shown no significant increase in overall mortality ratio and cancer risk ratio from occupational exposure to the radar frequency of workers. But, these results are not conclusive. As regards to some limitation such as fewer numbers of included studies, lack of data about exposure characterizations and demographic characterizations in this meta-analysis, this result is not certain and conclusive. It is recommended to conduct future studies.
- انتشار مقاله: 30-11-1397
- نویسندگان: Ali Safari Variani,Somayeh Saboori,Saeed Shahsavari,Saeed Yari,Vida Zaroushani
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: modeling,Keywords: Safety culture,Safety Climate,patient safety,Cancer treatment center
- چکیده:
- چکیده انگلیسی: Background: In health care institutions, safety culture is defined as the integrity of individual and group efforts to
reduce the harms for the patients. This is possible through interactions, attitudes, and understanding of safety matters.
On the other hand, one of the indicators of the safety culture is the safety climate. Objective: The aim of this study is
to investigate the interaction between safety climate and safety culture using structural equation modeling in personnel
of cancer treatment centers in Iran. Methods: In this study, 680 personnel of Iran’s hospitals were chosen in a random
manner. Demographic (9 questions), safety culture (42 questions) and safety climate (37 questions) questionnaires were
filled. The data were inserted in SPSS 20 software. Descriptive statistics method and Pearson’s correlation coefficient
were used to describe the data and evaluate the relation between the variables, respectively. Structural equations model
was developed using AMOS 22 software and fitness of the model was tested by χ2, RMSEA, GFI and NFI statistics.
Results: The scores of safety climate and safety culture were 3.61 and 3.30, respectively, which imply that they are
suiTable. The overall fitness of the model was accepTable. In this model, χ2 = 8637.17, df = 2964, χ2/df = 2.914,
RMSEA = 0.058, NFI = 0.912, GFI=0.907, and CFI=0.875. In the regression analysis, there were positive significant
relationships between safety climate and safety culture, safety climate and any of its components, and safety culture
and any of the components. Conclusion: It was found that the safety climate and the safety culture had a positive
impact on each other; so that with increasing safety climate, the safety culture also increases, and vice versa. Also, the
level of education has a positive impact on safety culture and safety climate. So appropriate training can promote both
variables in cancer treatment hospitals.- انتشار مقاله: 20-07-1397
- نویسندگان: Saeed Yari,Mohammad Hassan Naseri,Hamed Akbari,Saeed Shahsavari,Hesam Akbari
- مشاهده