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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: World Sociopolitical Studies
- نوع مقاله: Journal Article
- کلمات کلیدی: Iran,COVID-19,BBC,VOA,Media Framing
- چکیده:
- چکیده انگلیسی: The coronavirus pandemic has attracted the international media since the first infection was identified in Wuhan, China in late 2019. Despite the similar frames all around the world, the present study assumes that international media have not portrayed the countries with confirmed outburst of the disease in similar terms. It is believed that diseases in the world are both political and biological. The present study, therefore, employs media framing, as conducted by Entman and Van Gorp, to analyze the first fifty VOA and BBC Persian news that covered the spread of COVID-19 in Iran. These agencies are chosen for their significant position in the western public diplomacy and their probable influence within the country. The results indicate that the outbreak of COVID-19 in Iran is framed in seven major frame packages: Iran at crisis, Iran as the source of regional and international threatening virus, lack of determination and confidence in decision making in Iran, Iran’s incompetence and disqualification as an ill-equipped system, lying and hypocrisy in Iran, violation of human rights, and finally, Islamic political ideology as a source of corruption.
- انتشار مقاله: 15-06-1398
- نویسندگان: Zohreh Kharazmi,Saeed Mohammadi
- مشاهده
- جایگاه : پژوهشی
- مجله: Research Journal of Pharmacognosy
- نوع مقاله: Journal Article
- کلمات کلیدی: Iranian Traditional Medicine,Myrtus Communis,Hair loss,Phyllanthus emblica,amla
- چکیده:
- چکیده انگلیسی: Background and objectives: Iranian traditional medicine (ITM) resources have recommended different formulations for overcoming hair loss which is a beauty concern worldwide; one of these recommendations is amla oil which has been mentioned to be considerably effective. In the present study, amla oil has been formulated according to ITM and the quality control assessment of the product has been fulfilled. Methods: Phyllanthus emblica L. fruits (amla)and Myrtus communis L. leaves (myrtle) were provided from local market and their quality was evaluated according to pharmacopeia. The aqueous extract of myrtle was obtained by 24 h maceration; then amla was extracted in myrtle aqueous extract for 48 h. The mixture was filtered and sesame oil wasadded to the filtrate and heatedtill all water was evaporated. The resulting oil was assessed for viscosity, density, total phenolics and total tannins contents and acid and saponification values; the microbial content was also evaluated. Results: Amla oil was yellow in color with sesame odor. The acid value, viscosity, density, total phenolics and total tannins as pyrogallol were found to be 3.03 mg KOH/g, 102.8 cp, 0.966 g/mL, 0.2 and 0.05%, respectively. The product saponification value was zero and no microbial contamination was detected. Conclusion: The product showed proper physicochemical and microbial quality and could be suggested for treatment of hair loss after passing clinical trial.
- انتشار مقاله: 13-04-1397
- نویسندگان: Homa Hajimehdipoor*,Nasim Nikmanesh,Saeed Mohammadi-Motamed
- مشاهده
- جایگاه : پژوهشی
- مجله: Journal of Applied Research in Water and Wastewater
- نوع مقاله: Journal Article
- کلمات کلیدی: peak flow,Base flow,bridge pier,clear water,scour
- چکیده:
- چکیده انگلیسی: The local scour around the bridge piers is the main cause of their destruction. Based on this, extensive studies have been done to understand this phenomenon. Most of these studies have been done under steady flow conditions. This is while the flow in the river is unsteady. Therefore, the experiments of this research were carried out under unsteady flow conditions. The purpose of this research is to investigate the scour around the dual bridge piers at different distances of the piers from each other in a uniform flow as well as unsteady flow using symmetric hydrographs. The hydrographs used in the experiments are stepped hydrographs in 5 steps. The experiments were conducted under clear water conditions and U/UC=0.95. In all experiments, the diameter of the bridge pier (D) was constant and equal to 2.5 cm. The center-to-center distance between the dual bridge piers (S) was selected as 2D, 3D, 4D and 5D. In the unsteady flow, with increasing relative distance between the dual bridge piers, the maximum dimensionless scour depth of the first and second piers was increased and its maximum was measured at a relative distance of S/D=5 (in the range of relative distances studied in the research). But in the uniform flow, the maximum dimensionless scour depth of the first and second pier was observed at S/D=3 and S/D=4, respectively. Also, at a constant distance between the piers, increasing the peak and base flow of the hydrographs step-by-step, increased the maximum dimensionless scour depth of the first pier of dual bridge piers with an increasing rate. However, increasing the peak and base flow of the hydrographs step-by-step, increased the maximum dimensionless scour depth of the second pier with a decreasing and increasing rate, respectively.
- انتشار مقاله: 20-12-1398
- نویسندگان: Saeedeh Mohammadi Givshad,Yousef Ramezani,Hossein Khozeymehnezhad
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Pathology
- نوع مقاله: Journal Article
- کلمات کلیدی: treatment,systemic lupus erythematosus,IL-17,Pathogenesis,Glucocorticoids,organ damage
- چکیده:
- چکیده انگلیسی: Background & Objective: Systemic lupus erythematosus (SLE) is an autoimmune disease with chronic inflammatory immune response. Current therapies mostly rely on glucocorticoids which are accompanied by side-effects and mostly fail to achieve a favorable remission. Th17 subpopulation of T cells is increased in exacerbated SLE as IL-17 cytokine is overexpressed. However, IL-17 is reported to be resistant to glucocorticoids in various disorders. Here, we evaluated the plasma level of IL-17 among newly diagnosed and under-treatment SLE patients to understand the effect of glucocorticoids on Th17 response.
Methods: A total of 40 female SLE patients and 20 age- and sex- matched normal subjects were enrolled. IL-17 plasma level was evaluated using ELISA cytokine assay and analyzed with previously obtained IL-10, IFN-γ, and GILZ levels.
Results: Our findings revealed that IL-17 was overexpressed among under-treatment SLE patients. There was a significant correlation between IL-17 and IFN-γ and significant reverse correlations between IL-17, IL-10, and GILZ levels. IL-17 was not significantly correlated with the disease activity.
Conclusion: According to the role of IL-17 in tissue injury and the fact that glucocorticoids are not successful in preventing organ damages in SLE, the overexpressed IL-17 in response to therapies could be introduced as an underlying reason.- انتشار مقاله: 11-07-1397
- نویسندگان: Saeed Mohammadi,Sima Sedighi,Ali Memarian
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Medical Physics
- نوع مقاله: Journal Article
- کلمات کلیدی: Radiation Therapy,Monte Carlo method,Tooth,Electron,Restoration Material
- چکیده:
- چکیده انگلیسی: Introduction: Radiation therapy is regarded as the mainstay treatment for head or neck cancer patients. In this method, the backscattered radiation of dental composites can damage the surrounding tissue. Material and Methods: The current study compared the effects of electron beam radiation on healthy teeth with the tooth filled with materials used in dentistry with FLUKA and MCNPX2.6 codes. The simulation was performed for a 512 mm3 cubic tooth composed of Amalgam and Ceramco materials. Results: The simulation results indicated that patients with dental caries who inevitably filled their teeth with artificial restorationreceived a more effective dose, as compared to others. Moreover, it was revealed that Ceramco increases the radiation risk more than Amalgam does. Therefore, Amalgam is the right choice for dental filling. Conclusion: Based on the obtained results, ceramic material poses patients to increased radiation risk more than Amalgam does; therefore, it is recommended that Amalgam be used to fill dental cavities.
- انتشار مقاله: 15-12-1397
- نویسندگان: Mohamad Reza Rezaie Rayeni Nejad,Reza Shahhedarypoor,Saeed Mohammadi,Parviz Parvaresh
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Oil and Gas Science and Technology
- نوع مقاله: Journal Article
- کلمات کلیدی: Genetic Algorithm,blending,Kinematic viscosity,Heavy crude oil,Binary blend
- چکیده:
- چکیده انگلیسی: Dilution is one of the various existing methods in reducing heavy crude oil viscosity. In this method, heavy crude oil is mixed with a solvent or lighter oil in order to achieve a certain viscosity. Thus, precise mixing rules are needed to estimate the viscosity of blend. In this work, new empirical models are developed for the calculation of the kinematic viscosity of crude oil and diluent blends. Genetic algorithm (GA) is utilized to determine the parameters of the proposed models. 850 data points on the viscosity of blends (i.e. 717 weight fraction-based data and 133 volume fraction-based data) were obtained from the literature. The prediction result for the volume fraction-based model in terms of the absolute average relative deviation (AARD (%)) was 8.73. The AARD values of the binary and ternary blends of the weight fraction-based model (AARD %) were 7.30 and 10.15 respectively. The proposed correlations were compared with other available correlations in the literature such as Koval, Chevron, Parkash, Maxwell, Wallace and Henry, and Cragoe. The comparison results confirm the better prediction accuracy of the newly proposed correlations.
- انتشار مقاله: 19-06-1396
- نویسندگان: Saeed Mohammadi,Mohammad Amin Sobati,Mohammad Sadeghi
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Immunology
- نوع مقاله: Journal Article
- کلمات کلیدی: Rheumatoid arthritis,Regulatory T cells,disease activity,Soluble sLAG3
- چکیده:
- چکیده انگلیسی: Background: Rheumatoid arthritis (RA) is described as a systemic and chronic autoimmune disease characterized by inflammatory polyarthritis. Lymphocyte-activation gene 3 (LAG3) is a membrane glycoprotein expressed on activated, exhausted, and regulatory T cells. LAG3 plays a major role in the function of Treg cells. LAG3 also has a soluble form (sLAG3) with a controversial role. Objective: To evaluate the serum level of sLAG3 in rheumatoid arthritis patients in comparison with healthy subjects and assess its association with the disease activity. Methods: This cross-sectional study was performed on 105 patients with RA referred to Ghaem hospital of Mashhad, Iran. We divided the participants into four groups: 1) 35 untreated patients with newly diagnosed RA, 2) 35 active RA patients, 3) 35 patients in the remission phase of the disease, and 4) 35 healthy individuals matched in terms of age and sex. After completing the interview and questionnaire, the sLAG3 was evaluated by commercial ELISA. Results: The serum level of sLAG3 significantly increased in RA patients (76.78 ng/ml) as compared with the healthy participants (51.67, p=0.002). However, there was no significant difference between RA patients in the remission phase of the disease (114.11 ng/ml) and those with moderate to high disease activity (63.06 ng/ml, p=0.076). Conclusion: This study provided insights into the role of sLAG3 in the immunopathogenesis of RA disease, but further investigations are also warranted.
- انتشار مقاله: 23-06-1398
- نویسندگان: Nayyereh Saadati,Mandana Khodashahi,Zahra Rezaieyazdi,Maryam Sahebari,Zeinab Saremi,Saeed Mohammadian Haftcheshmeh,Houshang Rafatpanah,Maryam Salehi
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Immunology
- نوع مقاله: Journal Article
- کلمات کلیدی: Iran,systemic lupus erythematosus,Polymorphism,Intron 4,PDCD1
- چکیده:
- چکیده انگلیسی: Background: Programmed cell death protein 1 (PD-1) is a negative costimulatory molecule with immunomodulatory properties. Recently, PD-1 gene defects have attracted attention in the pathogenesis of SLE. Objective: Here, we assessed the association of PD-1 gene polymorphisms in intron 4 and haplotypes with the susceptibility to SLE. Method: Seventy-six SLE patients and 159 healthy controls were included. We screened the polymorphisms by amplifying the intron 4 of the PD-1 gene with the specific primers followed by sequencing. Results: Two distinct SNPs were identified (rs6705653 and rs41386439) within the intron 4 of the PD-1 gene. The AA genotype of +7499 (G/A) SNP was associated with the higher risk of SLE [OR=3.31, 95% CI (1.25-8.76), p-value=0.045], while A allele was identified as a risk allele [OR=1.75, 95% CI (1.10-2.76), p-value=0.015]. However, no significant association was observed between the allele and the genotype frequencies of +7209 (C/T) polymorphic region of the PD-1 gene and susceptibility to SLE. Haplotype analysis showed the significantly higher presence of H2 haplotype (AC; +7499/+7209) [OR=1.70, 95% CI (1.24-2.33), p-value=0.0012] in SLE patients. Conclusion: To the best of our knowledge, this is the first report of the significant association of PD-1 +7499 (G/A) SNP with the SLE susceptibility and the first detection of both polymorphic loci in a population from Iran. However, more investigations are necessary to confirm these findings.
- انتشار مقاله: 01-06-1398
- نویسندگان: Yousef Khanjari,Morteza Oladnabi,Nafiseh Abdollahi,Ahmad Heidari,Saeed Mohammadi,Alijan Tabarraei
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Basic Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: acute myeloid leukemia,Berberine,Aryl hydrocarbon receptor,Cell cycle regulation,THP-1
- چکیده:
- چکیده انگلیسی: Objective(s): Current acute myeloid leukemia (AML) therapeutic strategies have irreversible side-effects. Berberine (BBR) is an isoquinoline alkaloid, which has been known as an aryl hydrocarbon receptor (AhR) ligand. AhR is a cytoplasmic receptor, which is involved in the regulation of cellular and immune responses. Here, we investigated the expression profile of genes involved in the cell cycle and different cytokines upon BBR-mediated AhR activation on AML THP-1 cell line.
Materials and Methods: THP-1 cells and normal monocytes were treated with different concentrations of BBR (10 μM, 25 μM, 50 μM, and 100 μM) for 24 and 48 hr. The cell viability was measured by MTT assay. Real-time RT-PCR was conducted to evaluate the expression of AhR, cytochrome P450 1A1 (CYP1A1), interleukin 1 beta (IL1β), p21, p27, cyclin-dependent kinase 2 (CDK2) and p53. Cellular expression of AhR was also assessed using immunofluorescence method. ELISA was used to determine the level of IL-10 and IL-12 cytokines.
Results: BBR inhibits the proliferation of THP-1 cells in a dose- and time-dependent manner with minimal toxicity on normal monocytes. Phorbol 12-myristate 13-acetate (PMA) treatment increased the cellular expression of AhR. The AhR target genes (CYP1A1, IL1β) were overexpressed upon BBR treatment. BBR downregulated Cdk2 and upregulated p21, p27 and p53 genes in THP-1 cells. IL-10 was significantly increased upon BBR treatment, while IL-12 was not significantly changed in all combinations.
Conclusion: BBR could be introduced as an effective chemotherapeutic agent against AML by giving rise to the expression of CDK inhibitors and anti-inflammatory cytokines and downregulation of CDK2.- انتشار مقاله: 12-02-1396
- نویسندگان: Saeed Mohammadi,Fakhri Sadat Seyedhoseini,Jahanbakhsh Asadi,Yaghoub Yazdani
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Basic Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: Proliferation,Valproic acid,Pioglitazone,T-cell leukemia
- چکیده:
- چکیده انگلیسی: Objective(s): T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic malignant tumor. Administration of chemical compounds influencing apoptosis and T cell development has been discussed as promising novel therapeutic strategies. Valproic acid (VPA) as a recently emerged anti-neoplastic histone deacetylase (HDAC) inhibitor and pioglitazone (PGZ) as a high-affinity peroxisome proliferator-activated receptor-gamma (PPARγ) agonist have been shown to induce apoptosis and cell cycle arrest in different studies. Here, we aimed to investigate the underlying molecular mechanisms involved in anti-proliferative effects of these compounds on human Jurkat cells.
Materials and Methods: Treated cells were evaluated for cell cycle progression and apoptosis using flowcytometry and MTT viability assay. Real-time RT-PCR was carried out to measure the alterations in key genes associated with cell death and cell cycle arrest.
Results: Our findings illustrated that both VPA and PGZ can inhibit Jurkat E6.1 cells in vitro after 24 hr; however, PGZ 400 μM presents the most anti-proliferative effect. Interestingly, treated cells have been arrested in G2/M with deregulated cell division cycle 25A (Cdc25A) phosphatase and cyclin-dependent kinase inhibitor 1B (CDKN1B or p27) expression. Expression of cyclin D1 gene was inhibited when DNA synthesis entry was declined. Cell cycle deregulation in PGZ and VPA-exposed cells generated an increase in the proportion of aneuploid cell population, which has not reported before.
Conclusion: These findings define that anti-proliferative effects of PGZ and VPA on Jurkat cell line are mediated by cell cycle deregulation. Thus, we suggest PGZ and VPA may relieve potential therapeutic application against apoptosis-resistant malignancies.- انتشار مقاله: 17-05-1395
- نویسندگان: Marie Saghaeian Jazi,Saeed Mohammadi,Yaghoub Yazdani,Sima Sedighi,Ali Memarian,Mehrdad Aghaei
- مشاهده