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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Journal of Advanced Medical Sciences and Applied Technologies
- نوع مقاله: Journal Article
- کلمات کلیدی: Cardiac arrhythmia,Polymorphism,KCNQ1,cardiac disease risk factors
- چکیده:
- چکیده انگلیسی: Abstract
Objective:Many studies report that mutation in genes which encode the cardiac delayed rectifier potassium channel, such as KCNQ1, contributes to the long QT interval syndrome followed by cardiac arrhythmia.Goal of this case-control study is to explore the potential association between KCNQ1 gene promoter polymorphism and clinical Characteristics with cardiac arrhythmia in Bushehr population.
Methods:Clinical data, previous medical history, and blood samples were collected from 30 admitted patients in Bushehr hospitals with cardiac arrhythmia and matched healthy individuals as controls. The genetic variation of the promoter region of KCNQ1 was carried out by using single-strand conformational polymorphism (SSCP) analysis.
Results: NO mutation or polymorphism was identified in the promoter region of the KCNQ1 gene, but, the incidence rate of some cardiac disease risk factors, including diabetes mellitus, cigarette smoking, gender and age were significantly higher in the patients with cardiac arrhythmia.
Conclusions: The lack of mutation even in patients with a positive family history of cardiac arrhythmia revealed that mutation in the KCNQ1 gene might be not responsible for cardiac arrhythmia in the patients. But some clinical data, including diabetic mellitus, smoking habits, age and gender were the significant risk factors in patients with cardiac arrhythmia.- انتشار مقاله: 24-02-1398
- نویسندگان: Ameneh Bazrafshan,Saeed Khatamsaz,Farnaz Sani,Maryam Dehghan
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Basic Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: Learning,Morris Water Maze,Leptin resistance,Losartan,Memory performance
- چکیده:
- چکیده انگلیسی:
Objective(s):
Leptin is a hormone secreted by adipose tissue and is involved not only in the regulation of feeding and energy expenditure, but also its role in memory enhancement has been demonstrated as well. The partial transfer of leptin across the blood-brain barrier in obese individuals causes leptin resistance and prevents leptin reaching brain. On the other hand, studies have shown that angiotensin antagonists such as losartan can improve memory and learning abilities. The aim of this study was to evaluate the effects of losartan on improving memory and leptin resistance induced by high fat diet in obese rats.
Materials and Methods:
40 Wistar male rats were divided in 4 groups: control (C), losartan (LOS), high-fat diet (HFD) and high-fat diet and losartan (HFD and LOS). The spatial memory performances of the rats were assessed in the Morris water maze after 2 months of treatment. Then they were weighed and serum levels of leptin and triglyceride were measured.
Results:
In spite of receiving high-fat diet, no significant differences in body weight were observed in the (HFD & LOS) group. In the Morris water maze trial, the (LOS) and (HFD & LOS) groups also showed a significant reduction (P <0.05) in latency and path length. In addition, a significant decrease (P
<0.05) in serum levels of leptin and no significant difference in serum levels of triglyceride was observed in the (HFD & LOS) group.
Conclusion:
Losartan can improve leptin resistance induced by obesity and high fat diet. At the same time, it modulates body weight and enhances learning and memory.- انتشار مقاله: 05-11-1392
- نویسندگان: Seyydeh Gohar Sharieh Hosseini,Saeed Khatamsaz,Mehrdad Shariati
- مشاهده
- جایگاه : پژوهشی
- مجله: Advanced Herbal Medicine
- نوع مقاله: Journal Article
- کلمات کلیدی: Rat,Glycyrrhiza glabra root,Omega3 fish oil,Thioacetamide,biochemical factors
- چکیده:
- چکیده انگلیسی: Background and aims: Thioacetamide can lead to liver cirrhosis and hepatocarcinoma. This study was aimed to evaluate the ability of omega3 fish oil and Glycyrrhiza glabra aqueous extract to attenuate biochemical factors and liver tissue changes induced by thioacetamide.
Methods: In this experimental study, 63 wistar male rats were divided into 9 groups. Control group, Sham group received 0.4ml olive oil orally per day for 3 months. Thioacetamide group received 150 mg/kg of TAA intraperitoneally in a single dose for 3 months. Experimental groups 1, 2, 3, 4, 5 and 6 received 100, 200, 300 mg/kg of omega3 fish oil and aqueous extract of Glycyrrhiza glabra root orally per day for 3 months and 150 mg/kg of TAA intraperitoneally in a single dose for 3 months. The provided blood samples were tested for serum levels of bilirubin, albumin, and total protein. The pathological examination of hepatic tissue samples was done after hematoxylin and eosin staining.
Results: Treatment with 100 mg/kg of omega3 fish oil (0.06±0.013) significant reduced the serum level of billirubin comparing with thioacetamide group (0.38±0.015). Treatment with the aqueous extract of Glycyrrhiza glabra root at all doses (0.37±0.034) (0.34±0.027) (0.15±0.028) showed no significant difference in the serum level of billirubin comparing with thioacetamide group (0.38±0.015). Treatment with the omega3 fish oil (4.40±0.02) (4.32±0.10) (4.34±0.10) and aqueous extract of Glycyrrhiza glabra root at all doses (4.33±0.06) (4.31±0.5) (4.20±0.07) significant reduced the serum level of albumin comparing with thioacetamide group (4.70±0.00). The mean levels of total protein showed no significant difference in the experimental groups (8.77±0.31) (8.53±0.20) (8.63±0.24) (8.58±0.05) (8.57±0.10) (7.92±0.21) comparing with thioacetamide group (8.56±0.08). In all experimental groups, the hepatic tissue changes induced by thioacetamide improved which were dose dependent (P<0.05).
Conclusion: The study suggests that biochemical factors and liver tissue changes induced by thioacetamide in male rats can be ameliorated by oral administration of aqueous extract of Glycyrrhiza glabra root and omega3 fish oil.- انتشار مقاله: 20-11-1394
- نویسندگان: Davood Moghadamnia,Mokhtar Mokhtari,Saeed Khatamsaz
- مشاهده