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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Women’s Health Bulletin
- نوع مقاله: Journal Article
- کلمات کلیدی: Women,Immunity,Elderly,Combined training,Adipocytokines
- چکیده:
- چکیده انگلیسی: Background: Aging is a process in which the body’s physiological capacity continuously decreases after the age of 30. However, interventions such as physical activity can play an important role in the prevention of aging. Objectives: The purpose of this study was to compare the effects of eight weeks of combined training (endurance and resistance) in different orders on inflammatory factors and adipokines among elderly females. Patients and Methods: The design of this study was quasi-experimental. Forty healthy females were selected purposely and randomly assigned to one of four groups including strength after endurance training (E + S, n = 9), strength prior to endurance training (S + E, n = 10), circulation combined (CI, n = 12), and control (n = 9) groups. The training program was performed for eight weeks, three times per week. Within-group differences were analyzed using a paired samples t-test and between-group differences were analyzed using one-way analysis of variance (ANOVA). Results: The data analysis showed that the between group comparison did not influence the adaptive response of tumor necrosis factor (TNF)-α (P = 0.80), high sensitivity-C reactive protein (hs-CRP) (P = 0.55), adiponectin (P = 0.33), chemerin (P = 0.56), omentin (P = 0.51), leptin (P = 0.10) and vaspin (P = 0.70) levels, yet the within group comparison showed a significant difference in the chemerin concentration in the E+S group (P = 0.03). Conclusions: The results indicated that three different combined trainings (strength and endurance) had no positive effect on inflammatory factors and adipokines among aged females. However, the different combined trainings, independent of order, were effective training methods in reducing body fat and body mass index (BMI) in aged females.
- انتشار مقاله: 11-10-1348
- نویسندگان: Ebrahim Banitalebi,Zahra Mardanpour Shahrekordi,Abdol Reza Kazemi,Laleh Bagheri,Sadegh Amani Shalamzari,Mohammad Faramarzi
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Basic Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: VEGF,IL-6,Endurance Training,Estrogen receptor depen-dent cancer
- چکیده:
- چکیده انگلیسی: Objective(s): The goal of this study was assessing the prophylactic effect of exercise and its role as an adjuvant therapy on level of cytokines involved in angiogenesis in estrogen-dependent breast cancer.
Materials and Methods: Forty female BALB/c mice were randomly assigned to exercise-tumor-exercise (ETE), exercise-tumor-rest (ETR), rest-tumor-exercise (RTE) and rest-tumor-rest (RTR) groups. After orientation in the environment, two groups of mice performed continuous endurance exercise for 8 weeks, and thereafter estrogen-dependent MC4L2 cancer cells were injected to them. Then, one group of each of trained and non-trained mice performed endurance exercise 5 days per week for 6 weeks. Tumor volume was measured by a digital caliper weekly. Finally, the mice were sacrificed; tumor tissue was removed, immediately frozen and kept in -70°C. Tumor sample was homogenized; levels of cytokines were measured and quantified using ELISA.
Results: There was significant reduction in the level of interlukin-6 (IL-6) (P=0.001), Vascular endothelial growth factor (VEGF) (P=0.0001) and tumor volume (P=0.0001) among the groups performing endurance exercise after malignancy (RTE and ETE) in comparison with groups not performing endurance exercise (ETR and RTR), and these results were in agreement with tumor growth rate.
Conclusion: Exercise can cause reduction in levels of pro-inflammatory cytokines in tumor tissue. Decreased IL-6 production could reduce the generation of VEGF, resulting in reduced intra-tumor angiogenesis. Due to reduction of the level of these cytokines in groups doing exercise before and after malignancy, exercise is presumed to be an adjuvant therapy in estrogen-receptor dependent tumors in addition to its effective prophylactic role.- انتشار مقاله: 30-01-1393
- نویسندگان: Sadegh Amani Shalamzari,Hamid Agha-Alinejad,Shaban Alizadeh,Shirin Shahbazi,Zahra Kashani Khatib,AbdolReza Kazemi,Mohamad Amin Saei,Neda Minayi
- مشاهده