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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Iranian Journal of Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی:
- چکیده:
- چکیده انگلیسی: Background: Use of botulinum toxin is becoming a popular way in treatment of some forms of strabismus.To evaluate the morphological changes in the orbital surface layer muscles of the rabbit eye following a single injection of botulinum toxin. Methods: 10 white Dutch rabbits weighing 2–3 kg received either 10 units (group 1; n=5) or 20 units (group 2; n=5) of botulinum toxin into the superior rectus muscle of right eye. The superior rectus muscle of the left eye in each rabbit was considered as control. The diameter of at least 20 muscle fibers of the orbital layer of the superior rectus muscle was measured with an ocular micrometer on histological sections after extirpation 2 and 10 days, and 4, 8 and 12 weeks after the injection. Results: Marked decrease in size of muscle fibers was observed, especially on 2 and 10 days post-injection. It was more sever in animals which received 20 units of the toxin. In both groups, between 4 and 12 weeks after injection, the size of some fibers returned back to normal; rarely, the fibers became hypertrophic while atrophic changes were still present. Hypertrophy of neuromuscular end-plate was seen accompanied with atrophic changes. Fibrosis around the muscle fibers was rarely seen. Conclusion: Injection of botulinum toxin into extraocular muscles causes atrophic changes which seems to be more severe with higher doses. The effect of botulinum toxin has been persisted up to 8 weeks.
- انتشار مقاله: 04-03-1394
- نویسندگان: A. Attarzadeh,F. Sharifi,S.M. Owji,M. Eghtedari,M.R. Talebnejad
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی:
- چکیده:
- چکیده انگلیسی: Background: Urinary tract infection in children may cause renal scar formation, which can be prevented by early and appropriate treatment. Recent studies showed that single daily injection of gentamycin can produce best effect without increasing the side effects. The aim of this study was to evaluate the rate of renal scar formation when new regime (every other day gentamicin injection) used for treatment of urinary tract infection. Methods: Forty eight Sprague Dawley rats were infected by inoculation of 0.1 ml Uropathogenic E.coli suspension (109/ml) to their left kidneys. The rats were divided into four groups after 24 hours. Gentamicin was administrated intraperitoneally at dosages of 10mg/kg (daily), 10mg/kg every other day or 20mg/kg every other day to the first three groups. The fourth group did not receive any antibiotic. Renal scar formation was evaluated by histology and responses were evaluated by counting colony forming units (CFU)/ml of homogenized kidney tissue and percentage of sterile kidneys. Results: Evaluation of all sections showed that 0-30% of interstitial tissues had scar formation. The results showed no significant difference in scar formation between the first three groups, but showed mild to moderate scar formation in the fourth group. Conclusion: It was concluded that 10mg/kg or 20mg/kg of gentamicin usage in every other day interval dose did not increase the risk of renal scar formation while it had appropriate efficiency.
- انتشار مقاله: 30-02-1394
- نویسندگان: Fatemeh Emamghorashi,S.M. Owji,J. Kohanteb,N. Tanideh
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی:
- چکیده:
- چکیده انگلیسی: A 3-year-old girl was presented with periorbital edema, hypertension, proteinuria, and hematuria. She recovered clinically after 9 days with normal urinalysis. During the follow-up, she developed recurrent episodes of nephrotic syndrome. The kidney biopsy revealed mild mesangial proliferation and a low dose of prednisolone could effectively control the disease.Iran J Med Sci 2005; 30(1): 38-40. Keywords ● Glomerulonephritis ● Nephrotic syndrome ● C3
- انتشار مقاله: 09-06-1394
- نویسندگان: M.H. Fallahzadeh,S.M. Owji
- مشاهده