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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Overall Survival,Triple-negative breast cancer,Disease free-survival,Nottingham Prognostic Index
- چکیده:
- چکیده انگلیسی: Introduction: Triple-negative breast cancer (TNBC) is characterized by a poor prognosis due to high mortality
and early relapse, requiring the study of its prognostic factors. Tumor size, histological grade and lymph node status
represent important parameters that are widely studied in breast cancer, and are retained as prognostic factors by several
international guidelines. The Nottingham team combined these parameters into a prognostic score called the Nottingham
prognostic index (NPI). In this study, we investigated the influence of NPI on outcomes in non metastatic TNBC.
Methodology: This retrospective cohort study included all female patients with non metastatic TNBC who received
treatment at the Regional Oncology Center Hassan II Oujda - Morocco, between January 2009 and December 2011.
The prognostic impact of the NPI on the survival curves at 5 years was studied using multivariate Cox proportional
hazards models. Results: The analysis of the data involved 98 patients, 39 patients (39.8%) were classed in the poor
prognosis group with a NPI > 5.4. The Overall survival (OS) and Disease free survival (DFS) rates at 5 years, in this
group, were 70 and 55.6 % respectively. After adjusting for clinic-pathological variables, a NPI > 5.4 was associated with
mortality (HR: 2.598, 95% CI: 1.423 – 4.744, p = 0.002) and disease progression (HR: 2.512, CI to 95%: 1.496 – 4.219,
p <0.001) in patients with non-metastatic TNBC. Conclusion: This retrospective cohort analysis showed that NPI was
an independent prognostic factor for OS and DFS at 5 years in women with non metastatic TNBC. Once validated, the
impact of this score on survival outcomes could be considered in the clinical management of TNBC.- انتشار مقاله: 09-09-1396
- نویسندگان: O Al Jarroudi,A Zaimi,S A Brahmi,S Afqir
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Overweight,Body Mass Index,Overall Survival,Triple-negative breast cancer,Disease free-survival
- چکیده:
- چکیده انگلیسی:
Background: Obesity is associated with poor outcomes in patients with breast cancer expressing hormone receptors, but this association is not well established for triple-negative breast cancer. In this study, we investigated the influence of body mass index (BMI) in triple-negative breast cancer outcomes. Methods: This is a descriptive and analytical retrospective cohort study at the Regional Oncology Center Hassan II-Oujda. We identified 115 patients with triple-negative breast cancer, met the criteria for inclusion, treated between January 2009 and December 2011. The clinicopathological characteristics were collected to assess the association between BMI and overall survival and disease-free survival at 5 years, using the Kaplan-Meier and Cox model. Results: Data analysis focused on 115 patients, 34 patients (28.7%) were normal weight (BMI < 25) and 82 patients (71.3%) were overweight (BMI ≥ 25). The rates of overall mortality and progression at 5 years were 37.4% and 69.6% respectively. After adjusting for clinicopathological variables and menopausal status, overweight was associated with OS (HR: 2.903, 95% CI: 1.551- 5.432, p = 0.001) and DFS (HR:1.899, 95% IC: 1.05 – 3.433, p=0.034) in all patients with triple-negative breast cancer. When stratified by menopausal status, overweight was associated with DFS and OS (HR : 3.242, 95% CI: 1.249 to 8.412, p = 0.016) and (HR : 2.752, 95% CI: 1.267 to 5.978, p = 0.011) respectively in pre-menopausal women. By cons, BMI was not associated with DFS or OS in postmenopausal women. Conclusions: Overweight is an independent prognostic factor for OS and DFS at 5 years in all patients with triple-negative breast cancer, and menopausal status may be a mitigating factor. Premenopausal women with overweight are at greater risk of death and progression than women with normal weight. Once validated, these results should be considered in the development of prevention programs.- انتشار مقاله: 18-11-1395
- نویسندگان: Ouissam Al Jarroudi,Naima Abda,Youssef Seddik,Sami Aziz Brahmi,Said Afqir
- مشاهده