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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Platelet distribution width,cervical carcinoma,D-dimer,activated platelets,risk prediction
- چکیده:
- چکیده انگلیسی: Background: Deep venous thrombosis (DVT) is associated with severe morbidity and mortality in cancer. Platelet
distribution width (PDW), a platelet index, indicates variation in platelet size. We aimed to investigate whether the
combination of D-dimer and PDW could have a better performance in predicting DVT in patients with cervical
carcinoma. Materials and Methods: In 198 consecutive cervical carcinoma patients without preoperative DVT,
preoperative D-dimer and PDW levels were measured. Compression ultrasonography was performed in all cervical
carcinoma patients before surgery, as well as one month, three months, six months, and 12 months. Results: During a
median period of 12 months, 17 of the 198 patients (8.6 %) developed DVT. PDW levels were reduced and D-dimer
levels were increased in patients with DVT events compared to those without DVT. Multivariate Cox analysis revealed
that both PDW and D-dimer were independent predictors for DVT events. The area under the ROC curve was 0.628
(95% CI: 0.556 to 0.695, p=0.142) when D-dimer was used alone, whereas it increased to 0.777 (95% CI: 0.712 to
0.833, p<0.011) with the addition of PDW. Incorporation of PDW into the D-dimer model significantly improved the
predictive value. Conclusions: The combination of preoperative D-dimer and PDW improves the predictive power of
postoperative DVT risk in patients with cervical carcinoma.- انتشار مقاله: 02-10-1396
- نویسندگان: Na Li,Fu-Bin Zhang,Bing-Jie Li,Rui-Tao Wang
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Diagnosis,Prostate cancer,Benign prostate hyperplasia,Mean platelet volume,Platelet distribution width
- چکیده:
- چکیده انگلیسی: Background: Prostate cancer (PCa) represents the second most commonly diagnosed malignancy and the sixth
leading cause for cancer related death among men worldwide. Although use of the prostate specific antigen (PSA) as
a diagnostic marker has improved the detection and management of PCa, low specificity and sensitivity has limited its
clinical efficacy. Moreover, elevated PSA is frequently observed in benign prostate hyperplasia (BPH). Mean platelet
volume (MPV) and platelet distribution width (PDW) are commonly used indicators of platelet activation. The purpose
of current study was to investigate the ability of PSA, MPV, and PDW individually or in combination, to differentiate
PCa from BPH. Materials and Methods: This study included 100 patients with PCa and 108 patients with BPH. We
collected all participants’ clinical and laboratory characteristics. The benefit of adding MPV and PDW to a model
with only PSA was evaluated as an increased in the area under the curve (AUC) obtained by receiver operating curve
(ROC). Results: PCa patients had reduced MPV and elevated PSA and PDW levels compared to BPH patients. Single
biomarkers had AUC values ranging from 0.683 for PDW to 0.865 for PSA. Moreover, the combination of PSA, MPV,
and PDW increased the AUC to 0.935 (0.892-0.964) (p<0.0001), significantly higher than those of any single marker.
Conclusions: The combined use of PSA, MPV, and PDW may be clinically useful in distinguishing between PCa and
BPH.- انتشار مقاله: 22-03-1396
- نویسندگان: Shuang Fu,Xin Zhang,Ye Niu,Rui-Tao Wang
- مشاهده