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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Chemical Methodologies
- نوع مقاله: Journal Article
- کلمات کلیدی: Prostate cancer,Docking,Diaza-bicyclo-naphthalen-oxiranyl-methanone,derivative,Cytochrome P450 17A1
- چکیده:
- چکیده انگلیسی: Several agents have been used for the treatment of prostate cancer such as flutamide, galeterone, abiraterone and others; however, some of these drugs can produce some secondary effects. The aim of this study was to synthesize a diaza-bicyclo-naphthalen-oxiranyl-methanone derivative using some chemical tools. The structure of all compounds involved in this study was confirmed by spectroscopy and spectrometry data. In addition, the theoretical interaction of diaza-bicyclo-naphthalen-oxiranyl-methanone derivative with the cytochrome P450-17A1 enzyme (3RUK) was evaluated in a docking model using some drugs such as galeterone and abiraterone as controls. The results showed that diaza-bicyclo-naphthalen-oxiranyl-methanone could interact with different types of amino acid residues involving 3RUK protein surface as compared to both galeterone and abiraterone. This phenomenon may be due to the differences in the chemical structure of compounds. All these data indicate that diaza-bicyclo-naphthalen-oxiranyl-methanone derivative could change the biological activity of cytochrome P450-17A1 enzyme which may be translated as good candidates for prostate cancer.
- انتشار مقاله: 13-06-1397
- نویسندگان: Lauro Figueroa-Valverde,Diaz Cedillo Francisco,Rosas-Nexticapa Marcela,Mateu-Armand Virginia,Montano-Tapia Elizabeth,Lopez-Ramos Maria,García-Cervera Elodia,Pool Gómez Eduardo,Hau-Heredia Lenin,Alfonso-Jimenez Alondra,Cabrera-Tuz Jhair
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Journal of Green Chemistry
- نوع مقاله: Journal Article
- کلمات کلیدی: Breast cancer,Synthesis,Steroid,Derivatives,Docking
- چکیده:
- چکیده انگلیسی: Several compounds have been prepared to treatment of breast cancer; however, some of these drugs may produce some side effects. The aim of this study is to synthesize two new steroid derivatives (Compounds 7 or 8) to evaluate their theoretical interaction with a breast cancer protein (BRCA-1) using a docking model. The preparation of 7 and 8 was carried out using a series of reactions which involves; (i) addition/cyclization; (ii) amination, (iii) etherification and (iv) esterification. Chemical structure of the compounds was confirmed using elemental analysis and NMR spectrum. The following stage involved the theoretical evaluation on the interaction of both compounds 7 or 8 with BRCA-1 protein surface using a docking model. The results showed that compound 7 could bound to different type of amino acid residues of BRCA-1 protein compared with 8; this phenomenon, may exert changes in the biological activity of BRCA-1 protein. All data suggest that compound 7 or 8 could be an alternative therapeutic for treatment of the breast cancer.
- انتشار مقاله: 21-05-1397
- نویسندگان: Figueroa-Valverde Lauro,Diaz-Cedillo Francisco,Rosas-Nexticapa Marcela,Mateu-Armand Virginia,Montano-Tapia Elizabeth,Hau-Heredia Lenin,Lopez-Ramos Maria,García-Cervera Elodia,Pool-Gómez Eduardo,Cauich-Carrillo Regina,Alfonso-Jimenez Alondra,Cabrera-Tuz Jhaira
- مشاهده