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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: VETERINARY RESEARCH FORUM
- نوع مقاله: Journal Article
- کلمات کلیدی: Iran,West Azerbaijan,Cercariae,Lymnaea auricularia
- چکیده:
- چکیده انگلیسی: The pond snail Lymnaea auricularia serves as an intermediate host for many digenian species. In West Azerbaijan province, northwestern Iran, the cercariae infection investigation was undertaken in L. auricularia from May to November 2010. Of 6759 collected Lymnaeid snails, 370(5.5%) L. auricularia snails were identified. Cercariae infection was found in a number of 276 (74.56 %) snails. The results showed that removed cercariae from L. auricularia belonged to Echinostomcercariae (96.38 %) and Furcocercariae (3.62 %) which were found in two out of 28 sites during the course of study. In summer and fall, the highest prevalence of cercariae infection was recorded for both identified cercariae. It is concluded that L. auricularia could be an important intermediate host of large group digenian trematodes in the region, which is necessary to take consideration in the control program of trematode infection.
- انتشار مقاله: 07-10-1391
- نویسندگان: Abbas Imani-Baran,Mohammad Yakhchali,Reza Malekzadeh Viayeh,Farhad Farhangpajuh
- مشاهده
- جایگاه : پژوهشی
- مجله: Nanomedicine Journal
- نوع مقاله: Journal Article
- کلمات کلیدی: Radiology,Garments,Aprons,Non-lead shields,Patient Radiation Protection
- چکیده:
- چکیده انگلیسی: composites with micro- and nano-metal fillers has attracted the attention of researchers for radiation shielding applications. Lead toxicity and heaviness have oriented extensive research toward the use of non-lead composite shields. The present study aimed to systematically review the efficiency of the composite shields of various micro- and nano-sized materials as composite shields have been considered in radiation protection and diagnostic radiology. In addition, a meta-analysis was performed to determine the effects of filler size, filler type, shield thickness and tube voltage on dose reduction. The relevant studies published since 2000 were identified via searching in databases such as Google Scholar, Medline, Web of Science, Scopus, and Embase. In total, 51 articles were thoroughly reviewed and analyzed. Heterogeneity was assessed using the χ2 and I-square (I2) tests, and a fixed effects model was used to estimate the pooled effect sizes. The correlations between the subgroups were determined separately using meta-regression analysis. According to the results, the bismuth shield dose reduced from 22% to 98%, while the tungsten shield dose increased from 15% to 97%. The rate also increased from 6% to 84% in the barium sulfate shields. The combination of two metals resulted in higher attenuation against radiation, with the nano-shields exhibiting higher attenuation compared to the micro-shields, especially in low energies. Moreover, the meta-analysis indicated that the fixed effects pooled estimation of dose reduction was 89% for shield thickness (95% CI: 79-100; P<0.001), 73% for tube voltage (95% CI: 63-83; P<0.001; 50-100 kV), and 59% for tube voltage (95% CI: 35-82; P<0.001; kV>100). The single-metal personal shields made of bismuth powder had better performance than tungsten and barium sulfate. In addition, the combined metals in a shield showed more significant attenuation and dose reduction compared to the single-metal shields.
- انتشار مقاله: 23-02-1399
- نویسندگان: Parinaz Mehnati,Reza Malekzadeh,Mohammad Yousefi Sooteh
- مشاهده
- جایگاه : پژوهشی
- مجله: Nanomedicine Journal
- نوع مقاله: Journal Article
- کلمات کلیدی: Attenuation,Radiography,Nano Bi2O3,Shields
- چکیده:
- چکیده انگلیسی: Objective (s): Recently, the use of nanoparticles in medicine has increased for radiation protection purpose. So the aim of this study was application of nano Bi2O3 in prepared shield for dose reduction during medical imaging.
Materials and Methods: Nano Bi2O3 shield with 90% silicon and 10% nano Bi2O3 was prepared and dosimetry test was down in radiology by PTW DIADOS E dosimeter.
Results: The mean dose without using nano Bi2O3 shields were 421 µGy, 733 µGy and 1110 µGy for 60, 80 and 100 kVp , respectively. After using 0.5 mm thickness of nano Bi2O3 shield dose reduction in 60, 80 and 100 kVp was 42%, 35% and 31%. A comparison between increasing energy from 60 to 100 kVp and dose reduction showed a significant reverse effect.
Conclusion: The results indicate that the new shields containing nano Bi2O3 particles have a high X-rays attenuation ability but the attenuation property of the shields was decreased by the increasing of the energy. Based on the results, this new shield can help social health and decline the radiation risk.- انتشار مقاله: 04-07-1397
- نویسندگان: Parinaz Mehnati,Mohammad Yousefi Sooteh,Reza Malekzadeh,Baharak Divband
- مشاهده
- جایگاه : پژوهشی
- مجله: Nanomedicine Journal
- نوع مقاله: Journal Article
- کلمات کلیدی: Nanoparticles,Nanocomposite,Nuclear Medicine,radiation shielding
- چکیده:
- چکیده انگلیسی: Objective(s): The present study aimed to design new nanoparticle-based shielding materials for photons used in single-photon emission computed tomography and positron emission tomography facilities.
Materials and Methods: Initially, the mass attenuation coefficients and half value layer (HVL) of the composites were comprehensively investigated based on a silicon rubber containing various ratios of micro- and nano-barium sulfate (BaSO4), lead oxide (PbO), and tungsten oxide (WO3) particles at 60, 80, 100, 150, 200, 300, 400, 500, and 600 keV photon energies using the MCNP-X6 Monte Carlo (MC) code and WinXCOM software. In the second stage, the composites composed of 10 wt% and 20 wt% WO3 and PbO particles were constructed in a liquid silicone rubber-based matrix. The mass attenuation coefficients and HVL of the designed shields were experimentally assessed using Cs-137 and Am-241 radioactive sources.
Results: The particles sizes of PbO and WO3 were within the range of 50-200 nanometers. The MC and measurement results indicated that the linear attenuation coefficients of the composites were augmented with the addition of all the studied nano- and micro-particles. However, the PbO composites had more significant shielding properties compared to the BaSO4 and WO3 composites.
Conclusion: According to the results, the nanocomposites had better ability to shield γ-rays at both energies compared to the micro-composites.- انتشار مقاله: 19-03-1399
- نویسندگان: Reza Malekzadeh,Vahid Sadeghi Zali,Okhtay Jahanbakhsh,Murat Okutan,Asghar Mesbahi
- مشاهده
- جایگاه : پژوهشی
- مجله: Journal of Health Management and Informatics
- نوع مقاله: Journal Article
- کلمات کلیدی: Electronic health records,Technology,acceptance,physician,authority
- چکیده:
- چکیده انگلیسی: The purpose of the Electronic Healthcare Record is to improve the service quality by reducing medical errors, prevention, monitoring, diagnosis, prioritization, treatment, follow-up, provision of effective ways to communicate and share information between health care providers, and better health information. While benefiting EHCR, physicians just like to practice medicine. These changes have created a new level of complexity that makes physicians feel frustrated and dissatisfied with medical practice. Therefore, one of the factors that affect EHCR is the physician's authority, which affects the acceptance or non-acceptance of EHCR. Objective: The present study aimed to investigate the effect of using electronic health records on physicians’ authority. Method: Qualitative data collection was performed by a semi-structured interview with eight physicians, three specialists and four psychologists. The data collected show the users’ perceptions of the impact of EHCR on the physicians' careers. All participants experienced the use of EHR in the health care system. Results: A total of three dimensions were identified to assess the impact of the perceived threat of professional independence on the physician’s acceptance of EHCR, increased managers’ control, loss of professional privacy and professional authority, data trust, and security. When technology negatively affects the job roles, professional status, and independence, resistance is more likely to occur. Conclusion: The results of the study show that the design and implementation of EHCR should be in a way that does not threaten the autonomy of physicians. If the electronic health record system is designed and implemented without regard to the issue of autonomy, it will be nothing but a "cookbook" for doctors, and they will not welcome it.
- انتشار مقاله: 15-07-1399
- نویسندگان: Aref Shayganmehr,Gholamreza Malekzadeh,Mariusz Trojanowski
- مشاهده
- جایگاه : پژوهشی
- مجله: Journal of Dentistry, Shiraz University of Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: Analysis,discriminant function,Iranian children,Palatal rugae,Rugae Pattern,Forensic Identification,Sex Assessment
- چکیده:
- چکیده انگلیسی: Statement of the Problem: Palatal rugae have been considered equivalent to fingerprints, as they are unique to each individual. It has been shown that palatal rugae are associated with specific racial groups and are known to aid sex identification. Due to the lack of any published data on palatal rugae morphology on Iranian children, the present study was performed.Purpose: The present study aimed to investigate differences in the morphology of individual palatal in a sample of Iranian children. Additionally, it is intended to develop discriminant function to identify sex, based on rugae morphology.Materials and Method: A total of 120 pre-orthodontic casts were evaluated for different rugae patterns using the Thomas and Kotze classification. The casts were equally distributed between sexes with an age range of 6-12 years. Rugae length, shape, and associated morphology were recorded and the independent t test and Chi-square test were used to compare the mean and relationship between the attributes. The discriminant function analysis was applied to the data in order to determine the applicability of palatal rugae patterns as an aid for sex identification.Results: While the total rugae count showed an insignificant difference between the males and females, the rugae count on the right side of the palates showed a significant difference (p= 0.046). The primary rugae were most common in both sexes, followed by the secondary and fragmentary rugae. The most prevalent rugae shape between both sexes was the wavy rugae followed by the curve and straight shapes in males and the straight and curve shapes in females. A significant difference was observed in the number of the curve rugae between the sexes. Discriminant function analysis allowed sex differentiation with an accuracy of 60.8%.Conclusion: Palatal rugae shapes are unique to each individual and could be used as a potential tool for sex identification. Further research on a larger sample is required to fully confirm the application of this method (e.g. in forensic medicine) as a complementary technique for sex identification.
- انتشار مقاله: 26-09-1397
- نویسندگان: Fatemeh Pakshir,Shabnam Ajami,Hamidreza Pakshir,Alireza Malekzadeh
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: Iranian population,Forensic medicine,Palatal rugae,Sex identification
- چکیده:
- چکیده انگلیسی: Background: Palatal rugae have been shown to be associated with racial and geographical variations and are known to be useful in sex identification. The present study aimed to assess palatal rugae patterns in a sample Iranian population and to compare the results with those from other studied populations.Methods: During summer 2017, 130 pre-orthodontic plaster casts from patients aged 17-25 years (65 males and 65 females) were obtained from the Department of Orthodontics, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran. The castes were evaluated using the classification given by Thomas and Kotze followed by recording the rugae lengths and shapes. The data were analyzed with the SPSS statistical software package (version 15.0) using the unpaired t test and Chi-square test. P
- انتشار مقاله: 16-07-1396
- نویسندگان: Ali Reza Malekzadeh,Hamid Reza Pakshir,Shabnam Ajami,Fatemeh Pakshir
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Basic Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: Saliva,NMR,Metabolomics,Hepatitis B virus,Diagnostic biomarkers
- چکیده:
- چکیده انگلیسی: Objective(s): Hepatitis B virus infection causes chronic disease such as cirrhosis and hepatocellular carcinoma. The metabolomics investigations have been demonstrated to be related to pathophysiologic mechanisms in many disorders such as hepatitis B infection. The aim of this study was to investigate the saliva metabolic profile of patients with chronic hepatitis B infection and to identify underlying mechanisms as well as potential biomarkers associated with the disease.
Materials and Methods: Saliva from 16 healthy subjects and 20 patients with chronic hepatitis B virus were analyzed by nuclear magnetic resonance (NMR). Then, multivariate statistical analysis was performed to identify discriminative metabolites between two groups.
Results: A set of metabolites were detected, including propionic acid, putrescine, acetic acid, succinic acid, tyrosine, lactic acid, butyric acid, pyruvic acid, 4-pyridoxic acid and 4-hydroxybenzoic acid, which in combination with one another could accurately distinguish patients from healthy controls. Our results clearly demonstrated altered metabolites are involved in nine metabolic pathways.
Conclusion: Metabolomics has the potential to be considered as a novel clinical tool for hepatitis B diagnosis while contributing to a comprehensive understanding of disease mechanisms.- انتشار مقاله: 12-09-1397
- نویسندگان: Kambiz Gilany,Ashraf Mohamadkhani,Saeed Chashmniam,Parisa Shahnazari,Mehdi Amini,Babak Arjmand,Reza Malekzadeh,Bibi Fatemeh Nobakht Motlagh Ghoochani
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Basic Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: Saliva,NMR,Metabolomics,Hepatitis B virus,Diagnostic biomarkers
- چکیده:
- چکیده انگلیسی: Objective(s): Hepatitis B virus infection causes chronic disease such as cirrhosis and hepatocellular carcinoma. The metabolomics investigations have been demonstrated to be related to pathophysiologic mechanisms in many disorders such as hepatitis B infection. The aim of this study was to investigate the saliva metabolic profile of patients with chronic hepatitis B infection and to identify underlying mechanisms as well as potential biomarkers associated with the disease.
Materials and Methods: Saliva from 16 healthy subjects and 20 patients with chronic hepatitis B virus were analyzed by nuclear magnetic resonance (NMR). Then, multivariate statistical analysis was performed to identify discriminative metabolites between two groups.
Results: A set of metabolites were detected, including propionic acid, putrescine, acetic acid, succinic acid, tyrosine, lactic acid, butyric acid, pyruvic acid, 4-pyridoxic acid and 4-hydroxybenzoic acid, which in combination with one another could accurately distinguish patients from healthy controls. Our results clearly demonstrated altered metabolites are involved in nine metabolic pathways.
Conclusion: Metabolomics has the potential to be considered as a novel clinical tool for hepatitis B diagnosis while contributing to a comprehensive understanding of disease mechanisms.- انتشار مقاله: 12-09-1397
- نویسندگان: Kambiz Gilany,Ashraf Mohamadkhani,Saeed Chashmniam,Parisa Shahnazari,Mehdi Amini,Babak Arjmand,Reza Malekzadeh,Bibi Fatemeh Nobakht Motlagh Ghoochani
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Basic Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: Hepatitis B vaccine,HBsAg mutants,Hepatitis B immune epitopes
- چکیده:
- چکیده انگلیسی: Objective (s):The aim of this study was to determine the correlation between vaccine therapy and appearance of mutations in hepatitis B surface antigen (HBsAg)-positive chronic hepatitis B virus (HBV) patients. Materials and Methods: 16 patients received the HBV vaccine and another 16 individuals from the control group did not. The surface gene was amplified and directly sequenced from samples prior to vaccination and six months after the third dose. Results:Only one patient lost HBsAg. 48 and 44 amino acid mutations were found before and after vaccine therapy in the vaccine group respectively, 51 of which (55.4%) occurred in immune epitopes: 5 were in B cell, 21 in T helper (Th), and 25 in cytotoxic T-lymphocyte (CTL) epitopes. In the control group, 35 and 41 amino acid substitutions were found before and after therapy, respectively. 32 (42%) of 76 amino acid changes occurred within immune epitopes. There were no differences in age, gender, and duration of chronicity in both patient and control groups in terms of the frequency and the patterns of mutations. Conclusion: In chronic carriers who already had HBsAg variants selected by the host-immune response, any immune stimulation by the vaccine had no effect on the chronic state of these patients or selected any remarkable escape mutants. Newer strategies should be considered based on third generation or the use of DNA vaccines or new adjuvants.
- انتشار مقاله: 02-07-1393
- نویسندگان: Maryam Daram,Ghodratollah Montazeri,Hadi Karimzadeh,Reza Malekzadeh,Mahmood Mahmoodi,Zahra Goodarzi,Hossein Keyvani,Shahram Mirmomen,Seyed Moayed Alavian,Michael Roggendorf,Seyed Mohammad Jazayeri
- مشاهده