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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: p53,Glioblastoma,JC Virus,HCMV,large T Antigen
- چکیده:
- چکیده انگلیسی:
Glioblastoma multiforme (GBM) is the most aggressive of the gliomas, a collection of tumors arising from glia in the central nervous system. Possible associations between the human cytomegalovirus (HCMV) and the JC virus with GBM are now attracting interest. Our present aim was to investigate the prevalence of the two viruses in Iranian patients from Kerman’s cities in the south of Iran. In addition, the expression rates of pp65, large T antigen and p53 proteins were assessed and their relation with GBM evaluated using reverse transcription real time PCR (rReal Time PCR) . A total of 199 patients with GBM cancer were enrolled, with mean±SD ages of 50.0±19.5 and 50.7±19.6 years for males and females, respectively. The P53 rate was dramatically low suggesting an aetiological role,. Large T antigen expression was found in JC positive samples, while the PP65 antigen was observed in patients positive for CMV and JC . HCMV products and JC virus with oncogenic potential may induce the development of various tumors including glioblastomas. The JC virus produces an early gene product, T-antigen, which has the ability to associate with and functionally inactivate well-studied tumor suppressor proteins including p53 and pRB .- انتشار مقاله: 13-06-1395
- نویسندگان: Reza Malekpour Afshar,Hamidreza Mollaei,Bahare Zandi,Maryam Iranpour
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Iran,Breast cancer,Kerman,Human papilloma virus
- چکیده:
- چکیده انگلیسی: Breast cancer is the first of the most important causes of the deaths of women in the world and in Iran. There are
various causes and causes of this cancer, one of which has recently been described as a cause of breast cancer, is the human
papillomavirus (HPV). The HPV is transmitted through sexual contact and skin lesions. There are more than 100 types of
HPV that can influence different parts of the body. Some types of HPV can cause cancer (such as cervical or anal cancer)
and others can cause warts (such as genital or plantar warts). To study the risk of HPV infection in Breast Cancer, we
managed a Case-Control study in Kerman, southeast of Iran. For this purpose, 98 paraffin blocks of breast cancer and
40 paraffin blocks of fibrocystic as a control were tested for the presence of HPV DNA using Real-Time PCR, and
HPV typing was done using INNo-Lippa assay. HPV DNA was detected in 8 out of 98 patients (8.2%), while it was
not detected in the control group samples. HPV types 16, 18 were the most common (62.5%) types in positive samples.
The prevalence of HPV in patients with breast cancer of Iran is very low and less than other regions of the world,
it seems that maybe rout of transmission of HPV in Iran is under control. No one knows exactly why breast cancer
occurs. The environment, hormones, Viruses, or your lifestyle could all play a role in the development of breast cancer.
Currently, Vaccination is the best way to prevent cancer that’s due to HPV. However, additional studies on the larger
group of patients are needed to explain the roles of HPV in Breast cancer.- انتشار مقاله: 03-07-1396
- نویسندگان: Reza Malekpour Afshar,Negin Balar,Hamid Reza Mollaei,Seyed Alimohammad Arabzadeh,Maryam Iranpour
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Southeast of Iran,cancer registry,Kerman,population-based
- چکیده:
- چکیده انگلیسی: Introduction: The epidemiology of common cancers in Kerman province, southeast of Iran, was assessed based
upon results of the Kerman Population-Based Cancer Registry Program (KPBCR). Methods: in this retrospective study,
all patients diagnosed with primary cancers and registered with the KPBCR were included. New cancer cases registered
from 2014 were identified from pathological labs, medical reports of 48 health facilities providing cancer diagnosis or
treatment services and the national death registry program. Data for patients who were referred to neighboring provinces
to access health services were also collected from national referral registries. Results from autopsies was additionally
extracted from regional forensic and legal medicine centers and added to the registry periodically. Age standardized
incidence rates (ASRs) per 100,000 person-years for all cancers were computed, using direct-standardization and CanReg
methodology. Mortality to incidence (M:I) ratios and microscopically verified (MV) proportions were calculated as
quality measures. Results: A total of 2,838 cases of cancer were registered in Kerman province, 2014. Of these 45. 6%
involved women (n=1,293). Individuals aged 60-64 years represented the largest proportion (11.6%) of the total cancer
prevalence, followed by those aged 55-59 years (10.86%) and 65-69 years (8.99%). The ASRs for all cancers were
155.1 and 118.90 per 100,000, in men and women, respectively. In women, breast (ASR: 26.4), skin (ASR: 13.0),
thyroid (ASR: 9.2), leukemia (ASR: 8.0) and colorectal (ASR: 7.70) were the most common cancers. In men, bladder
(ASR: 24.70), skin (ASR: 16.80), lung (ASR: 14.6), leukemia (ASR: 14.50), and stomach (ASR: 10.8) were found to
be the most frequent. Conclusion: This study provided latest evidence on epidemiology of cancer in the southeast of
Iran that could be used to empower prevention and control interventions in a developing country.- انتشار مقاله: 14-06-1396
- نویسندگان: Armita Shahesmaeili,Reza Malekpour Afshar,Azadeh Sadeghi,Azam Bazrafshan
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Colorectal cancer,HPV,Real Time PCR,HPV Genotype
- چکیده:
- چکیده انگلیسی:
Background: The HPV virus is known to be oncogenic and associations with many cancers has been proven. Although many studies have been conducted on the possible relationship with colorectal cancer (CRC), a definitive role of the virus has yet to be identified. Method: In this cross-sectional study, the frequency of HPV positivity in CRC samples in Kerman was assessed in 84 cases with a mean age of 47.7 ± 12.5 years over two years. Qualitative real time PCR was performed using general primers for the L1 region of HPV DNA. Results: Out of 84 CRC samples, 19 (22.6%), proved positive for HPV DNA. Genotyping of positive samples showed all of these to be of high risk HPV type. Prevalence of HPV infection appears to depend geographic region, life style, diet and other factors. Conclusion: In our location frequency of CRC is low, and this limited the sample size for evaluation of HPV DNA. The most prevalent types were HPV types 51 and 56. While HPV infection may play an important role in colorectal carcinogenesis, this needs to be assessed in future studies.- انتشار مقاله: 11-07-1396
- نویسندگان: Reza Malekpour Afshar,Zeinab Deldar,Hamid Reza Mollaei,Seyed Alimohammad Arabzadeh,Maryam Iranpour
- مشاهده