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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: International Journal of Pediatrics
- نوع مقاله: Journal Article
- کلمات کلیدی: children,lead,Blood,Failure to Thrive
- چکیده:
- چکیده انگلیسی: Background
Lead is a strong and stable toxin, harmful especially to children, pregnant women, and the elderly. Nearly 27% of children aged under 5 years suffer from failure to thrive (FTT). Due to the probable harmful effects of lead poisoning on children’s growth, in this study we aimed to assess the blood lead level in children with unexplained failure to thrive.
Methods
This analytic cross-sectional study was performed on 200 children under 2 years of age who were referred to Ghaem hospital, a referral hospital in Mashhad city-Iran. The participants were divided into two equal groups, one with unexplained FTT (group A), and children with normal weight (group B). Baseline characteristics were obtained by a research-made questionnaire. Blood samples were taken by the hospital nurses who were blind to the study groups. Blood lead level was measured by atomic absorption spectrophotometric method (Perkin Elmer 3030).
Results
The mean ± standard deviation (SD) of blood lead level in FTT group and control group were 7.3±3.32 µg/dL and 6.37±5.93 µg/dL, respectively. Blood lead level was significantly higher in FTT group than control group (P=0.001). Baseline Charactistics (such as hgender, parental educational level, gestational age, and socio-economic status of the family) were not significantly different between the two groups (P>0.05).
Conclusion
The results of our study revealed that blood lead level was higher in children with FTT. So Lead poisoning may be a potential cause of unexplained FTT. So, measuring blood lead level can be useful in diagnostic workup of patients with FTT.- انتشار مقاله: 16-09-1397
- نویسندگان: Simin Torabian,Mohammad Ali Kiani,Alizadeh Ghamsari Anahita,Seyed Ali Jafari,Masumeh Saeidi,Ali Khakshour,Seyed Javad Sayedi,Hamidreza Kianifar
- مشاهده
- جایگاه : پژوهشی
- مجله: International Journal of Pediatrics
- نوع مقاله: Journal Article
- کلمات کلیدی: Probiotics,Pediatrics,Diarrhea,Yogurt consumption
- چکیده:
- چکیده انگلیسی: Background
The popularity of probiotics is on the rise. Despite the beneficial effects of antibiotics, gastrointestinal health is at risk of diarrhea. This study aimed to investigate whether probiotic yogurt is of capability to prevent the incidence of diarrhea versus conventional yogurt.
Materials and Methods
This controlled, randomized, double-blind trial was designed to recruit 48 hospitalized children, whose treatments included different types of antibiotics. They were subsequently assigned into a 1:1 ratio into groups A and B at random. The first group was instructed to consume probiotic yogurt (Bifidobacterium strains and Lactobacillus acidophilus), while the second were on conventional yogurt (placebo containing Streptococcus thermophiles and Lactobacillus bulgaricus) at least for 7 days. The incidence of diarrhea, its onset and duration were compared between the two groups.
Results
The findings indicated that there was no statistically significant difference between the experimental and control groups (p > 0.05). No significant decrease was observed in the incidence of diarrhea between the groups following adjustment for negative C-reactive protein (CRP) (p > 0.05).
Conclusion
According to the results, the consumption of yogurt, either probiotic or conventional, reduced the incidence, duration, and onset of antibiotic-associated diarrhea in pediatric population. This study showed no significantly better performance for probiotic yogurt than conventional yogurt.- انتشار مقاله: 25-07-1396
- نویسندگان: Majid Khademian,Mohammad Ali Kiani,Seyed Ali Jafari,Hamid Ahanchian,Niloofar Sedghi,Fatemeh Behmanesh,Ali Khakshour,Hamidreza Kianifar
- مشاهده
- جایگاه : پژوهشی
- مجله: International Journal of Pediatrics
- نوع مقاله: Journal Article
- کلمات کلیدی: Cystic fibrosis,Dermatglyphics,Palm patterns,Asymmetry a-b ridge count,ATD angel
- چکیده:
- چکیده انگلیسی: Background
Dermatoglyphics could assist in the diagnosis of congenital abnormalities. The aim of this study was to identify the dermatoglyphic patterns (finger print pattern type, total ridge count of each finger, a-b ridge count, and articulotrochanteric distance [ATD angles]) in the parents of cystic fibrosis children.
Materials and Methods
We recruited 75 parents of children with cystic fibrosis for the study group and 341 parents for the control group. We recorded finger print pattern type, total ridge count (TRC), a-b ridge count, and ATD angles of all participants. Then we identified any asymmetry between the right and left hands of each person and characteristics of parents in two genders. Chi-square analysis, Mann-Whitney U test, and Fisher's exact test were used for data analysis.
Results
We observed significant differences in a-b ridge count on the right hand (P=0.02), and mean total ridge count on the right digit I (P=0.05), right digit IV (P=0.03), and right digit V in the fathers of children with cystic fibrosis compared to the control group(P=0.02).
Conclusion
According to the results, we suggest that the dermatoglyphic traits of parents could be used as a simple, appropriate, and supplementary screening method in the diagnosis of children with CF. Nevertheless, we need lager studies to precisely confirm that dermatoglyphics is a reliable method in the diagnosis of CF.- انتشار مقاله: 05-05-1396
- نویسندگان: Hamid Reza Kianifar,Atefeh Ezzati,Seyed Ali Jafari,Mohammad Ali Kiani,Hamid Ahanchian,Hasan Karami,Ezzat Khodashenas,Arezoo Jahanbin
- مشاهده
- جایگاه : پژوهشی
- مجله: International Journal of Pediatrics
- نوع مقاله: Journal Article
- کلمات کلیدی: anxiety,children,depression,Celiac disease,Gluten free diet
- چکیده:
- چکیده انگلیسی: Background
Celiac disease (CD) is a systemic autoimmune disorder due to immune response triggered by ingestion of gluten in the diet. Treatment with lifelong gluten-free diet may impact negatively on the health-related quality of life and may lead to psychological disturbances. The purpose of study was to evaluate quality of life, depression and anxiety in children with celiac disease.
Materials and Methods
In this cross-sectional study was done between 2013 and 2014 at the Gastroenterology Outpatient Clinic (Ghaem Hospital, Mashhad- Iran), patients with serology and biopsy-proven CD, on a gluten-free diet for at least one year, were included in this study and compared with non-celiac healthy children as controls. We used the questionnaire to investigate quality of life, anxiety and depression.
Results
There were statistically significant differences between the mean total anxiety (state, trait) scores and depression score in the celiac patients and control group. Correlations between state and trait anxiety and depression were statistically significant (P= 0.01, r= 0.35) and (P= 0.001, r= 0.52). Reverse correlations between quality of life of CD children and anxiety (state, trait) were statistically significant (P= 0.001, r= 0.51 and P= 0.02, r= 0.32). Mean total score of quality of life was not different in the two groups, but in the physical activity component, quality of life was better in CD patients (P=0.008).
Conclusion
In current study, anxiety and depression had a significant impact on the course of celiac disease.- انتشار مقاله: 06-03-1396
- نویسندگان: Seyed Ali Jafari,Saeedeh Talebi,Nazanin Mostafavi,Fatemeh Moharreri,Hamidreza Kianifar
- مشاهده
- جایگاه : پژوهشی
- مجله: International Journal of Pediatrics
- نوع مقاله: Journal Article
- کلمات کلیدی: Valproic acid,Liver failure,Liver transaminases
- چکیده:
- چکیده انگلیسی: Introduction
Valproic acid (VPA, Valproate) is an eight-branch fatty acid and varies from other
antiepileptic drugs. VPA use might lead to mild to severe hepatotoxicity.
The aim of this study was to investigate valproic acid impact on liver transaminases
at the beginning of VPA treatment and after three and six months of it.
Materials and Methods
This study was designed as a cross sectional project in Pediatrics Neurology
ward of a Tertiary Academic Hospital (Ghaem Hospital, Mashhad-Northeastern
Iran). All children who needed valproic acid therapy alone were selected for study.
Liver function test was performed for them at the beginning of VPA administration,
three and six months after VPA, respectively. Data was analyzed by SPSS version 16.
Results
60 children with mean age of 49±28.6 months were entered the study.
37 of them were male and 23 were female. 5% (3 children) were mental retard
and 11.7% (7 patients) had neurologic or developmental deficit. Mean value of
Aspartate Aminotransferase (AST), Alanine Transferase (ALT) and Alkaline
phosphatase (ALP) were 27, 30.8 and 30.4 and 17.4, 20.7 and 22.8 and 425,
426 and 441 at the beginning of VPA administration, three and six months after
VPA, respectively. In six months of our follow up, only one child (1.7%) had elevated
liver transaminases.
Conclusion
Regard to our findings and its agreement with previous researches, it is important to
control adverse drug events by measuring liver transaminases during antiepilepsy treatment.- انتشار مقاله: 20-01-1394
- نویسندگان: Javad Akhondian,Mohammad Ali Kiani,Seyed Ali Jafari,Mehran Beiraghi Toosi,Mansoureh Mirzaei Najm Abad,Hamid Ahanchian,Hamidreza Kianifar
- مشاهده
- جایگاه : پژوهشی
- مجله: International Journal of Pediatrics
- نوع مقاله: Journal Article
- کلمات کلیدی: Prevention,Synbiotic,Antibiotic-Associated Diarrhea
- چکیده:
- چکیده انگلیسی: Introduction
Antibiotic- associated diarrhea is a common problem in pediatric population. There is growing interest in probiotics, probiotics and synbiotics for prevention of this complication because of their worldwide availability as dietary supplements. The aim of this study was to assess the efficacy of a synbiotic mixture in prevention of antibiotic- associated diarrhea.
Materials and Methods:
In this randomized controlled trial, 218 patients ( 111 in the synbiotic and 107 in the placebo group) aged 6 months to 14 years with respiratory tract infection and/ or otitis media who needed antibiotic treatment in outpatient setting, were enrolled. They received 1 billion Colony Forming Unit of seven probiotics species plus Fructooligosaccharide in form of powder or placebo ( matched for size, shape, and volume) for 7 days. Amoxicillin, Amoxicillin-clavalanic acid, cefixim and Azithromicin were the most common drugs used by physcicians Mothers recorded stool frequency and consistency daily for 7 days.
Results:
We found no significant difference (P>0.05) in occurrence of diarrhea between synbiotic and placebo groups.
Conclusion:
This synbiotic mixture did not appear to reduce antibiotic- associated diarrhea in children. Further studies are needed to investigate the potential benefits of Synbiotics in prevention of this disease.
- انتشار مقاله: 01-09-1392
- نویسندگان: Seyed Ali Jafari,Hamid Ahanchian,Mohammad Ali Kiani,Ali Khakshour,Zeinab Noorbakhsh,Elham Zamani,Hamid Reza Kianifar
- مشاهده
- جایگاه : پژوهشی
- مجله: International Journal of Pediatrics
- نوع مقاله: Journal Article
- کلمات کلیدی: Choronic Liver Disease,Cirrhosis,PELDMELD Score
- چکیده:
- چکیده انگلیسی: Introduction:
Chronic liver diseases consist of wide spectrum disorders that may be complicated by cirrhosis and therefore need to transplantation. The pediatric end-stage liver disease (PELD) score and model of end-stage liver disease (MELD) score has been used as predictors of mortality chronic liver diseases listed for liver transplantation. The aim of this study is evaluation of relation between PELDMELD score and evidence of cirrhosis in children with choronic liver disease.
Materials and Method:
This cross-sectional study conducted on 106 patients of chronic liver disease referred to Ghaem Haspital, Mashhad University of Medical Science, Iran during 24 months period (2010-2013). PELD and MELD score were calculated for all patients. Clincal and patholoogical findings of cirrhosis were recorded.
Results:
Mean age of patients was 68/3 ± 41.8 months. Mean PELDMELD score was -1/59± 9/64. There was significant correlation between PELDMELD score and clinical icter, spelenomegaly, evidence of hepatopulminary syndrome, esophageal varices, evidence of cirrhosis in tissue specimences.
Conclusion:
PELDMELD score appear to be benefit for detection of cirrhotic children among paients with choronic liver disease.- انتشار مقاله: 02-09-1392
- نویسندگان: Hamid Reza Kianifar,Sanaz Jafarzadeh Fakhari,Maryam Khalesi,Mohammad Ali Kiani,Atefeh Ezzati,Seyed Ali Jafari
- مشاهده
- جایگاه : پژوهشی
- مجله: International Journal of Pediatrics
- نوع مقاله: Journal Article
- کلمات کلیدی: Prevention,Synbiotic,Antibiotic-Associated Diarrhea
- چکیده:
- چکیده انگلیسی: Introduction
Antibiotic- associated diarrhea is a common problem in pediatric population. There is growing interest in probiotics, probiotics and synbiotics for prevention of this complication because of their worldwide availability as dietary supplements. The aim of this study was to assess the efficacy of a synbiotic mixture in prevention of antibiotic- associated diarrhea.
Materials and Methods:
In this randomized controlled trial, 218 patients ( 111 in the synbiotic and 107 in the placebo group) aged 6 months to 14 years with respiratory tract infection and/ or otitis media who needed antibiotic treatment in outpatient setting, were enrolled. They received 1 billion Colony Forming Unit of seven probiotics species plus Fructooligosaccharide in form of powder or placebo ( matched for size, shape, and volume) for 7 days. Amoxicillin, Amoxicillin-clavalanic acid, cefixim and Azithromicin were the most common drugs used by physcicians Mothers recorded stool frequency and consistency daily for 7 days.
Results:
We found no significant difference (P>0.05) in occurrence of diarrhea between synbiotic and placebo groups.
Conclusion:
This synbiotic mixture did not appear to reduce antibiotic- associated diarrhea in children. Further studies are needed to investigate the potential benefits of Synbiotics in prevention of this disease.
- انتشار مقاله: 01-09-1392
- نویسندگان: Seyed Ali Jafari,Hamid Ahanchian,Mohammad Ali Kiani,Ali Khakshour,Zeinab Noorbakhsh,Elham Zamani,Hamid Reza Kianifar
- مشاهده
- جایگاه : پژوهشی
- مجله: International Journal of Pediatrics
- نوع مقاله: Journal Article
- کلمات کلیدی: Choronic Liver Disease,Cirrhosis,PELDMELD Score
- چکیده:
- چکیده انگلیسی: Introduction:
Chronic liver diseases consist of wide spectrum disorders that may be complicated by cirrhosis and therefore need to transplantation. The pediatric end-stage liver disease (PELD) score and model of end-stage liver disease (MELD) score has been used as predictors of mortality chronic liver diseases listed for liver transplantation. The aim of this study is evaluation of relation between PELDMELD score and evidence of cirrhosis in children with choronic liver disease.
Materials and Method:
This cross-sectional study conducted on 106 patients of chronic liver disease referred to Ghaem Haspital, Mashhad University of Medical Science, Iran during 24 months period (2010-2013). PELD and MELD score were calculated for all patients. Clincal and patholoogical findings of cirrhosis were recorded.
Results:
Mean age of patients was 68/3 ± 41.8 months. Mean PELDMELD score was -1/59± 9/64. There was significant correlation between PELDMELD score and clinical icter, spelenomegaly, evidence of hepatopulminary syndrome, esophageal varices, evidence of cirrhosis in tissue specimences.
Conclusion:
PELDMELD score appear to be benefit for detection of cirrhotic children among paients with choronic liver disease.- انتشار مقاله: 02-09-1392
- نویسندگان: Hamid Reza Kianifar,Sanaz Jafarzadeh Fakhari,Maryam Khalesi,Mohammad Ali Kiani,Atefeh Ezzati,Seyed Ali Jafari
- مشاهده
- جایگاه : پژوهشی
- مجله: International Journal of Pediatrics
- نوع مقاله: Journal Article
- کلمات کلیدی: Prevention,Synbiotic,Antibiotic-Associated Diarrhea
- چکیده:
- چکیده انگلیسی: Introduction
Antibiotic- associated diarrhea is a common problem in pediatric population. There is growing interest in probiotics, probiotics and synbiotics for prevention of this complication because of their worldwide availability as dietary supplements. The aim of this study was to assess the efficacy of a synbiotic mixture in prevention of antibiotic- associated diarrhea.
Materials and Methods:
In this randomized controlled trial, 218 patients ( 111 in the synbiotic and 107 in the placebo group) aged 6 months to 14 years with respiratory tract infection and/ or otitis media who needed antibiotic treatment in outpatient setting, were enrolled. They received 1 billion Colony Forming Unit of seven probiotics species plus Fructooligosaccharide in form of powder or placebo ( matched for size, shape, and volume) for 7 days. Amoxicillin, Amoxicillin-clavalanic acid, cefixim and Azithromicin were the most common drugs used by physcicians Mothers recorded stool frequency and consistency daily for 7 days.
Results:
We found no significant difference (P>0.05) in occurrence of diarrhea between synbiotic and placebo groups.
Conclusion:
This synbiotic mixture did not appear to reduce antibiotic- associated diarrhea in children. Further studies are needed to investigate the potential benefits of Synbiotics in prevention of this disease.
- انتشار مقاله: 01-09-1392
- نویسندگان: Seyed Ali Jafari,Hamid Ahanchian,Mohammad Ali Kiani,Ali Khakshour,Zeinab Noorbakhsh,Elham Zamani,Hamid Reza Kianifar
- مشاهده