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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Journal of Dentistry, Shiraz University of Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: Saliva,gram negative bacteria,Hepatic disorder
- چکیده:
- چکیده انگلیسی: Statement of the Problem: Liver cirrhosis is the end stage of liver failure. It is mentioned as one of the main etiologies of morbidity and mortality in the world. The human salivary bacteria may induce oral disorders and interact with other body microbiota.
Purpose: The aim of the present study is to identify the pathogenic bacteria of non-oral origin from the saliva samples of patients with end stage liver failure.
Materials and Method: In this cross-sectional study, the saliva samples of 88 end stage liver disease cases and 84 age- and sex-matched healthy subjects were collected. The samples were cultured using gram staining and API20E Kit.
Results: According to the statistical analysis, the total amount of the non-commensal bacteria was significantly higher in chronic liver failure (CLF) group than controls (p = 0.001). There was no significant difference between both groups for the presence of other bacteria (p = 0.001) except for Escherichia coli (E. coli). E. coli was isolated from the saliva of 15 cases and only 2 controls.
Conclusion: Oral cavity may act as a reservoir for enteric bacteria such as E. coli in liver failure patients. Adequate oral and general hygiene might reduce the risk of systemic infection especially in immunocompromised cases.- انتشار مقاله: 26-08-1397
- نویسندگان: Janan Ghapanchi,Abdollah Bazargani,Hooman Khorshidi,Maryam Erfani,Fahimeh Rezazadeh,Azita Azad,Reza Derafshi,Ahmad Hassan Kalantari
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Single Nucleotide Polymorphism,Oral lichen planus,programmed cell death protein,Autoimmune Disease
- چکیده:
- چکیده انگلیسی: Background: The association between programmed cell death protein 1 (PD-1) variations and susceptibility to
autoimmune diseases has been recurrently reported. However, there is no report about its relationship with oral lichen
planus (OLP) as one of autoimmune diseases. Methods: We investigated the association between genetic predisposition
to OLP and two single nucleotide polymorphisms in PD-1. Results: GG, GA, and AA genotypes at position +7146
were found in 59 (80.8 %), 10 (13.7 %), and 4 (5.5 %) patients, and in 132 (77 %), 34 (20 %), and 5 (3 %) healthy
participants. CC, CT, and TT genotypes at position +7785 were found in 32 (43.8 %), 35 (47.9 %), and 6 (8.2 %) patients
and in 99 (58 %), 66 (39 %), and 6 (3 %) controls. Analysis indicated that patients’ genotypes were not statistically
different from controls’ genotypes at both positions +7146 (P = 0.35 and P = 0.98) and +7785 (P = 0.07 and P = 0.06).
Conclusion: The findings indicated that PD-1 SNPs at +7146 [PD-1.3] G/A and +7785 [PD-1.5] C/T was not associated
with susceptibility to OLP. However, further research with higher sample size and in different geographical regions is
needed in order to achieve the generalizability of the findings.- انتشار مقاله: 30-10-1396
- نویسندگان: Janan Ghapanchi,Hamid Ghaderi,Mohammad Reza Haghshenas,Samira Jamshidi,Fahimeh Rezazadeh,Azita Azad,Mitra Farzin,Reza Derafshi,Ahmad Hasan Kalantari
- مشاهده