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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Reviews in Clinical Medicine
- نوع مقاله: Journal Article
- کلمات کلیدی: non-small cell lung cancer,Systematic review,Esophageal Cancer,Sentinel
- چکیده:
- چکیده انگلیسی: Introduction: Sentinel node mapping is a new technique of lymph nodal staging in solid tumors, which can decrease the morbidity of regional lymph node dissection considerably. Intra-thoracic tumors including non-small cell lung cancer (NSCLC) and esophageal carcinoma (EC) are among the solid tumors in which sentinel node (SN) mapping has been applied. In the current systematic review, we gathered the best available evidence (systematic reviews) in this regard and presented the results in a systematic review format.
Material and methods: We searched MEDLINE and SCOPUS since the inception till 13 December 2014 using the following keywords: (lung OR esophagus OR esophageal) AND sentinel AND (“systematic review” OR meta-analysis OR metaanalysis). No language limit was imposed on the search strategy. Systematic reviews and meta-analyses on SN mapping in EC or NSCLC were included in the current study. Narrative review articles were excluded from the study.
Results: Overall five systematic review were included. One of the included studies was on SN mapping in NSCLC and four were on EC. Overall detection rate and sensitivity for EC and NSCLC were high and both were related to mapping technique, pathological involvement of the mediastinal nodes, size and location of the tumors.
Conclusion: SN mapping is feasible and highly accurate in EC and NSCLC. Attention to the technique (using radiotracers, peri-tumoral injection) and restriction of the patients to less advanced cases (cN0 and T1, 2) would ensure the best results with high detection rate and sensitivity.
- انتشار مقاله: 01-10-1393
- نویسندگان: Susan Shafiei,Reza Bagheri,Kayvan Sadri,Amir Hossein Jafarian,Davood Attaran,Shahrzad Mohammadzadeh Lari,Reza Basiri,Amir Mohammad Hashem Asnaashari,Ramin Sadeghi
- مشاهده
- جایگاه : پژوهشی
- مجله: Reviews in Clinical Medicine
- نوع مقاله: Journal Article
- کلمات کلیدی: non-small cell lung cancer,Systematic review,Esophageal Cancer,Sentinel
- چکیده:
- چکیده انگلیسی: Introduction: Sentinel node mapping is a new technique of lymph nodal staging in solid tumors, which can decrease the morbidity of regional lymph node dissection considerably. Intra-thoracic tumors including non-small cell lung cancer (NSCLC) and esophageal carcinoma (EC) are among the solid tumors in which sentinel node (SN) mapping has been applied. In the current systematic review, we gathered the best available evidence (systematic reviews) in this regard and presented the results in a systematic review format.
Material and methods: We searched MEDLINE and SCOPUS since the inception till 13 December 2014 using the following keywords: (lung OR esophagus OR esophageal) AND sentinel AND (“systematic review” OR meta-analysis OR metaanalysis). No language limit was imposed on the search strategy. Systematic reviews and meta-analyses on SN mapping in EC or NSCLC were included in the current study. Narrative review articles were excluded from the study.
Results: Overall five systematic review were included. One of the included studies was on SN mapping in NSCLC and four were on EC. Overall detection rate and sensitivity for EC and NSCLC were high and both were related to mapping technique, pathological involvement of the mediastinal nodes, size and location of the tumors.
Conclusion: SN mapping is feasible and highly accurate in EC and NSCLC. Attention to the technique (using radiotracers, peri-tumoral injection) and restriction of the patients to less advanced cases (cN0 and T1, 2) would ensure the best results with high detection rate and sensitivity.
- انتشار مقاله: 01-10-1393
- نویسندگان: Susan Shafiei,Reza Bagheri,Kayvan Sadri,Amir Hossein Jafarian,Davood Attaran,Shahrzad Mohammadzadeh Lari,Reza Basiri,Amir Mohammad Hashem Asnaashari,Ramin Sadeghi
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Basic Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: Flowcytometry,Interleukin 23,Mycobacterium – tuberculosis,Purified protein – derivative,Th17
- چکیده:
- چکیده انگلیسی: Objective(s): Tuberculosis is one of the most important infectious diseases with high mortality rates worldwide, especially in developing countries. Interleukin17 (IL-17) is an important acquired immunity cytokine, which is mainly produced by CD4+TH17 cells. It can recruit neutrophils and macrophages to the infected site in the lungs. IL-23 is one of the most important inducers of IL-17. In the present study, the expressions of IL-23 and IL-17 were examined in the pathogenesis of tuberculosis.
Materials and Methods: Peripheral blood mononuclear cells (PBMCs) were isolated from subjects with latent tuberculosis infection (LTB) and newly diagnosed active tuberculosis patients (ATB).
PBMCs were activated with purified protein derivative (PPD) for 72 hr. Activated cells were harvested, RNA was extracted, and cDNA was synthesized. IL-17 and IL-23 mRNA expressions were evaluated by real-time PCR. The frequency of Th17 cells was examined by flowcytometry.
Results: The expressions of IL-17 and IL-23 mRNA were lower in patients than subjects with LTB (P<0.05). The frequency of IL-17 producing CD4+ T cells in patients with active TB was lower than LTB subjects (P<0.05).
Conclusion: The results of the present study might suggest that IL-17 and IL-23 play critical roles in the immune response against TB.- انتشار مقاله: 10-06-1395
- نویسندگان: Fatemeh Heidarnezhad,Amir Asnaashari,Seyed Abdolrahim Rezaee,Roghayeh Ghezelsofla,Kiarash Ghazvini,Narges Valizadeh,Reza Basiri,Aghigh Ziaeemehr,Somayeh Sobhani,Houshang Rafatpanah
- مشاهده