در هنگام جستجو کلمه در قسمت عنوان میتوانید کلمات مورد جستجو را با کاراکتر (-) جدا کنید.
کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Journal of Industrial Strategic Management
- نوع مقاله: Journal Article
- کلمات کلیدی: Marketing,Commercial complex,Model of success
- چکیده:
- چکیده انگلیسی: In recent years, the construction of commercial complexes has been increasingly grown across the country. However, only some of them have been successful to accommodate a large number of visitors while others are constantly changing the commercial units’ use. Meanwhile the lack of demand for commercial units in the form of multi-purpose complexes as well as recent general recession in the country’s economy has deteriorated this situation. Therefore, the main problem of this research is to provide a model for the success of the commercial complexes based on the local approach. Grounded theory method has been used in order to theorize and identify the dimensions of the model. Then the qualitative proposed model is tested and implemented in a commercial complex in Tehran. The model dimensions and their relationships are confirmed based on exploratory and confirmatory factor analysis and structural equation modeling.
- انتشار مقاله: 21-10-1396
- نویسندگان: Hossein Mombeini,Mehdi Fathollahi,Mohammadreza Asadollahi,Alireza Bakhshizadeh
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Immunology
- نوع مقاله: Journal Article
- کلمات کلیدی: Breast cancer,Progesterone Receptor,IL-10,Polymorphism
- چکیده:
- چکیده انگلیسی: Background: IL-10 is an anti-inflammatory cytokine which is involved in tumorigenesis. Over production of IL-10 and elevated number of IL-10 generating mononuclear cells in breast tumor tissue has already been shown.
Objective: To determine the association of IL-10 promoter polymorphisms with increased risk of breast cancer and its association with breast cancer prognostic factors.
Methods: Peripheral blood samples from 275 female breast cancer patients and 320 cancer free controls were used to detect three single nucleotide polymorphisms in IL-10 promoter region ( -1082, -819, -592 ) by PCR method.
Results: The frequency of genotypes and alleles of three mentioned regions of IL-10 promoter and their haplotypes (GCC, ATA, and ACC) showed no statistically significant difference between patients and controls. In the case of prognostic factors, progesterone receptor (PR) status exhibited significant relation with -1082 genotypes (P=0.03) and haplotypes (P=0.02). -1082 AA genotype was associated with negative PR expression whereas AG and GG genotypes of this site were positively associated with PR expression. Similarly GCC haplotype correlated with positive PR expression and ATA and ACC with negative PR expression.
Conclusion: The data of this study showed that IL-10 promoter gene polymorphisms may not be considered as one of the risk factors for breast cancer in Iranian patients.- انتشار مقاله: 16-05-1395
- نویسندگان: Hossein Abdolrahim-Zadeh,Niloufar Hakkakian,Reza Asadollahi,Behrouz Gharesifard,Jamal Sarvari,Eskandar Kamali-Sarvestani,Abdolrasoul Talei
- مشاهده