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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Iranian Journal of Immunology
- نوع مقاله: Journal Article
- کلمات کلیدی: children,Immunogenicity,23-Valent Pneumococcal Vaccine,Anti-Pneumococcal Antibody,Systemic Lupus Erythematosus (SLE)
- چکیده:
- چکیده انگلیسی: Background: Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease which is characterized by B-cell abnormality and auto-antibody generation. Since bacterial infections are the most important causes of mortality in these patients, pneumococcal vaccination is recommended for children with SLE.
Objective: To investigate humoral immunity and specific-antibody formation in response to a 23-valent polysaccharide pneumococcal vaccination in SLE children and asthmatic control group.
Method: The case and control groups consisted of 30 children with the mean age of 13 years who were matched by sex and age. Anti-pneumococcal antibody titers were determined using Enzyme-Linked Immunosorbent Assay (ELISA) before the vaccination with the 23-valent pneumococcal vaccine and 3 weeks later in both groups. Also the correlation between anti-pneumococcal antibody titer and different factors including age, sex, lupus activity, disease duration, medications, history of recurrent infections, and laboratory data were investigated.
Results: Both groups showed significant increases in anti-pneumococcal antibody level after vaccination (p≤0.001). The increase in antibody level were almost the same in both groups (p≥0.05) such that 77.7% of SLE children and 86.2% of control children showed at least 2-fold increase in anti-pneumococcal antibody titer following immunization. Significant correlations were seen between the level of post-immunization anti-pneumococcal antibody with the age of children with SLE (p=0.02) and their age of disease onset (p=0.02).
Conclusion: It is concluded that pneumococcal vaccination is generally immunogenic in children with SLE. However, a small group of patients show impaired response to the vaccine.- انتشار مقاله: 06-07-1395
- نویسندگان: Soheila Alyasin,Marzieh Adab,Asieh Hosseinpour,Reza Amin,Maryam Babaei
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Immunology
- نوع مقاله: Journal Article
- کلمات کلیدی:
- چکیده:
- چکیده انگلیسی: Background: IL-17 is a major cytokine player in T cell mediated leukocyte associated inflammation. IL-17 is also recognized to participate in the pathophysiology of asthma.
Objective: To determine the role of IL-17 in predicting severe asthma.
Methods: We obtained serum samples from asthmatic children under the age of 5-year in three different groups of mild (n=33), moderate (n=28) and severe (n=32) persistent asthma. IL-17 serum concentrations and mRNA expression were determined by ELISA and real time PCR assays, respectively.
Results: Serum IL-17 concentrations were significantly higher in patients with severe asthma than the other two groups of children with mild and moderate disease (p=0.00). Mean serum IL-17 values were 142.04 pg/ml in mild group, 180.4 pg/ml in moderate group and 251.25 pg/ml in severe group. IL-17 mRNA levels were also significantly elevated in severe asthmatic patients compared to mild and moderate asthmatic children (p=0.00).
Conclusion: Our data reveal an increase in the serum IL-17 concentrations and IL-17 mRNA expressions in children with severe asthma compared to those with mild and moderate forms of the disease.- انتشار مقاله: 15-05-1395
- نویسندگان: Soheila Alyasin,Mohammad Hossein Karimi,Reza Amin,Maryam Babaei,Sepideh Darougar
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Immunology
- نوع مقاله: Journal Article
- کلمات کلیدی: IgG,Thalassemia Major,IgA,IgM,C3 and C4
- چکیده:
- چکیده انگلیسی: Background: Beta-thalassemia major is one of the major health problems in our country. Many studies have confirmed the fact that, these patients have an increased susceptibility to bacterial infections.
Objective: In this study, we have assessed the humoral immune system in 68 thalassemic patients by measuring their serum concentration of Immunoglobulin G (IgG), IgM, IgA, C3 and C4 in order to find out a responsible immune defect.
Methods: Sixty eight b-thalassemia major patients were enrolled randomly from referrals to Dastgheib clinic of thalassemia. The same number of case controls with matched age and sex were selected from healthy people without any history of recent or recurrent infections. Serum IgG, IgM, IgA, C3 and C4 levels were assessed using Single Radial Immunodiffusion (SRID).
Results: Serum levels of IgG, IgM & IgA were significantly higher (P<0.01) and those of C3 and C4 were significantly lower (P<0.01) in thalassemic patients than the controls. Considering the result of analytic tests, it was revealed that, thalassemia patients show much more increase in serum immunoglobulin levels as they get older. Splenectomized patients had higher serum IgG and IgA levels than non-splenectomized patients but had no difference in serum IgM, C3 and C4. Serum ferritin level had no correlation with the changes of humoral immunity; however, patients with serum ferritin level >2500ng/ml had higher serum IgM level.
Conclusion: These results can be due to continuous exposure to antigens, repeated infections, chronic liver disease and splenectomy but not iron overload. The only probable cause of humoral immune deficiency found in these patients is a defect in serum complement levels.- انتشار مقاله: 16-05-1395
- نویسندگان: Ahmad Amin,Susan Jalali,Reza Amin,Soheila Aale-yasin,Nima Jamalian,Mehran Karimi
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Immunology
- نوع مقاله: Journal Article
- کلمات کلیدی: Prevalence,Allergic Rhinitis,Eosinophilia
- چکیده:
- چکیده انگلیسی: Background: Allergic rhinitis is one of the most common forms of allergic disorders affecting children. The prevalence rate of allergic rhinitis differs among countries and even among regions within the same country.
Objectives: To determine the prevalence of childhood allergic rhinitis and the presence and significance of eosinophilia in nasal secretions.
Method: 4584 children aged 11-15 years-old of both sexes with allergic rhinitis were studied. The study was done during a four-season period. After physical examination of the nose, smear was taken from nasal secretions and it was stained. The results compared with nasal smears related to 340 healthy children controls.
Results: 445 cases (9.7%) were diagnosed as having allergic rhinitis, on the basis of clinical criteria. Significant nasal eosinophilia was present in 274 (62%) of children with allergic rhinitis. 226 students (5.8%) of Shiraz school children had proven or classic allergic rhinitis.
Conclusion: Allergic rhinitis is one of the major health problems among children in Shiraz. Eosinophilia of nasal secretions had a diagnostic specificity of 96% and sensitivity of 62% and seems to be having a moderate value as screening test for nasal allergy.- انتشار مقاله: 15-05-1395
- نویسندگان: Hedaiat Akbari,Reza Farid-Hosseini,Sara Miri,Reza Amin
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Immunology
- نوع مقاله: Journal Article
- کلمات کلیدی: Arthritis,systemic lupus erythematosus,Anticardiolipin antibody,Antiphospholipid syndrome,Juvenile Rheumatoid
- چکیده:
- چکیده انگلیسی: Background: Antiphospholipid antibody syndrome (APS) can either occur as a primary syndrome or associated with other autoimmune diseases such as systemic lupus erythematosus (SLE). Anticardiolipin antibody (aCL) of IgG and/or IgM isotype in blood, measured by a standardized ELISA is the most acceptable laboratory criteria. APS IgG isotype, particularly IgG2 subclass is more strongly associated with thrombosis.
Objectives: This study was done to determine the prevalence of IgG aCL and its subclasses in relation to APS symptoms, in a group of juvenile rheumatoid arthritis (JRA) and juvenile systemic lupus erythematosus (SLE) patients.
Methods: In this prospective study, 28 JRA and 16 SLE patients, aged 3-18 years, were enrolled. IgG aCL was assayed by standard aCL ELISA. IgG subclasses were also assayed by ELISA on sera with medium to high titers of aCL. ACL assay was performed on at least two occasions for each patient, over 3-6 months period of follow up.
Results: 29% (8/28) of JRA patients and 44% (7/16) of SLE patients had aCL. Six of SLE patients displayed APS related manifestations: hemolytic anemia, thrombocytopenia, arterial occlusion, valvular heart disease, livedo reticularis and pulmonary hypertension, but none of them had persistant medium or high titer of aCL. The lack of association of high titer of aCL with APS related symptoms was observed in two patients. The IgG subclasses were primarily IgG1 and IgG3.
Conclusion: The prevalence of IgG aCL in this group of pediatric SLE and JRA is not uncommon but it’s relation to clinical manifestations is not clear. IgG1 and IgG3 subclasses were not associated with thrombosis, which is in agreement with previous studies.- انتشار مقاله: 15-05-1395
- نویسندگان: Sara Kashef,Reza Amin,Maryam Ayatollahi,Abbas Ghaderi
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Immunology
- نوع مقاله: Journal Article
- کلمات کلیدی: Prevalence,Allergic Rhinitis,Eosinophilia
- چکیده:
- چکیده انگلیسی: Background: Allergic rhinitis is one of the most common forms of allergic disorders affecting children. The prevalence rate of allergic rhinitis differs among countries and even among regions within the same country.
Objectives: To determine the prevalence of childhood allergic rhinitis and the presence and significance of eosinophilia in nasal secretions.
Method: 4584 children aged 11-15 years-old of both sexes with allergic rhinitis were studied. The study was done during a four-season period. After physical examination of the nose, smear was taken from nasal secretions and it was stained. The results compared with nasal smears related to 340 healthy children controls.
Results: 445 cases (9.7%) were diagnosed as having allergic rhinitis, on the basis of clinical criteria. Significant nasal eosinophilia was present in 274 (62%) of children with allergic rhinitis. 226 students (5.8%) of Shiraz school children had proven or classic allergic rhinitis.
Conclusion: Allergic rhinitis is one of the major health problems among children in Shiraz. Eosinophilia of nasal secretions had a diagnostic specificity of 96% and sensitivity of 62% and seems to be having a moderate value as screening test for nasal allergy.- انتشار مقاله: 15-05-1395
- نویسندگان: Hedaiat Akbari,Reza Farid-Hosseini,Sara Miri,Reza Amin
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Immunology
- نوع مقاله: Journal Article
- کلمات کلیدی: Arthritis,systemic lupus erythematosus,Anticardiolipin antibody,Antiphospholipid syndrome,Juvenile Rheumatoid
- چکیده:
- چکیده انگلیسی: Background: Antiphospholipid antibody syndrome (APS) can either occur as a primary syndrome or associated with other autoimmune diseases such as systemic lupus erythematosus (SLE). Anticardiolipin antibody (aCL) of IgG and/or IgM isotype in blood, measured by a standardized ELISA is the most acceptable laboratory criteria. APS IgG isotype, particularly IgG2 subclass is more strongly associated with thrombosis.
Objectives: This study was done to determine the prevalence of IgG aCL and its subclasses in relation to APS symptoms, in a group of juvenile rheumatoid arthritis (JRA) and juvenile systemic lupus erythematosus (SLE) patients.
Methods: In this prospective study, 28 JRA and 16 SLE patients, aged 3-18 years, were enrolled. IgG aCL was assayed by standard aCL ELISA. IgG subclasses were also assayed by ELISA on sera with medium to high titers of aCL. ACL assay was performed on at least two occasions for each patient, over 3-6 months period of follow up.
Results: 29% (8/28) of JRA patients and 44% (7/16) of SLE patients had aCL. Six of SLE patients displayed APS related manifestations: hemolytic anemia, thrombocytopenia, arterial occlusion, valvular heart disease, livedo reticularis and pulmonary hypertension, but none of them had persistant medium or high titer of aCL. The lack of association of high titer of aCL with APS related symptoms was observed in two patients. The IgG subclasses were primarily IgG1 and IgG3.
Conclusion: The prevalence of IgG aCL in this group of pediatric SLE and JRA is not uncommon but it’s relation to clinical manifestations is not clear. IgG1 and IgG3 subclasses were not associated with thrombosis, which is in agreement with previous studies.- انتشار مقاله: 15-05-1395
- نویسندگان: Sara Kashef,Reza Amin,Maryam Ayatollahi,Abbas Ghaderi
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Immunology
- نوع مقاله: Journal Article
- کلمات کلیدی: Arthritis,systemic lupus erythematosus,Anticardiolipin antibody,Antiphospholipid syndrome,Juvenile Rheumatoid
- چکیده:
- چکیده انگلیسی: Background: Antiphospholipid antibody syndrome (APS) can either occur as a primary syndrome or associated with other autoimmune diseases such as systemic lupus erythematosus (SLE). Anticardiolipin antibody (aCL) of IgG and/or IgM isotype in blood, measured by a standardized ELISA is the most acceptable laboratory criteria. APS IgG isotype, particularly IgG2 subclass is more strongly associated with thrombosis.
Objectives: This study was done to determine the prevalence of IgG aCL and its subclasses in relation to APS symptoms, in a group of juvenile rheumatoid arthritis (JRA) and juvenile systemic lupus erythematosus (SLE) patients.
Methods: In this prospective study, 28 JRA and 16 SLE patients, aged 3-18 years, were enrolled. IgG aCL was assayed by standard aCL ELISA. IgG subclasses were also assayed by ELISA on sera with medium to high titers of aCL. ACL assay was performed on at least two occasions for each patient, over 3-6 months period of follow up.
Results: 29% (8/28) of JRA patients and 44% (7/16) of SLE patients had aCL. Six of SLE patients displayed APS related manifestations: hemolytic anemia, thrombocytopenia, arterial occlusion, valvular heart disease, livedo reticularis and pulmonary hypertension, but none of them had persistant medium or high titer of aCL. The lack of association of high titer of aCL with APS related symptoms was observed in two patients. The IgG subclasses were primarily IgG1 and IgG3.
Conclusion: The prevalence of IgG aCL in this group of pediatric SLE and JRA is not uncommon but it’s relation to clinical manifestations is not clear. IgG1 and IgG3 subclasses were not associated with thrombosis, which is in agreement with previous studies.- انتشار مقاله: 15-05-1395
- نویسندگان: Sara Kashef,Reza Amin,Maryam Ayatollahi,Abbas Ghaderi
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Immunology
- نوع مقاله: Journal Article
- کلمات کلیدی: Prevalence,Allergic Rhinitis,Eosinophilia
- چکیده:
- چکیده انگلیسی: Background: Allergic rhinitis is one of the most common forms of allergic disorders affecting children. The prevalence rate of allergic rhinitis differs among countries and even among regions within the same country.
Objectives: To determine the prevalence of childhood allergic rhinitis and the presence and significance of eosinophilia in nasal secretions.
Method: 4584 children aged 11-15 years-old of both sexes with allergic rhinitis were studied. The study was done during a four-season period. After physical examination of the nose, smear was taken from nasal secretions and it was stained. The results compared with nasal smears related to 340 healthy children controls.
Results: 445 cases (9.7%) were diagnosed as having allergic rhinitis, on the basis of clinical criteria. Significant nasal eosinophilia was present in 274 (62%) of children with allergic rhinitis. 226 students (5.8%) of Shiraz school children had proven or classic allergic rhinitis.
Conclusion: Allergic rhinitis is one of the major health problems among children in Shiraz. Eosinophilia of nasal secretions had a diagnostic specificity of 96% and sensitivity of 62% and seems to be having a moderate value as screening test for nasal allergy.- انتشار مقاله: 15-05-1395
- نویسندگان: Hedaiat Akbari,Reza Farid-Hosseini,Sara Miri,Reza Amin
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of English for Academic Purposes
- نوع مقاله: Journal Article
- کلمات کلیدی: Awareness,Phrasal Verbs,conceptual metaphor,Cognitive Linguistics
- چکیده: قابلیت فهم و کاربرد فعلهای چندقسمتی، به عنوان دستهای از کلمهها که عموماً با هم میآیند، بخش مهمی از یادگیری زبان است. مقالة حاضر به بررسی تاثیر آگاهیبخشی دربارة استعارههای مفهومی، به عنوان یک روش آموزشی نوین مبتنی بر یافته های زبانشناسی شناختی، بر یادگیری فعلهای چند قسمتی انگلیسی توسط زبانآموزان ایرانی سطح متوسط میپردازد. بدینمنظور، دو گروه شاهد و آزمایشی از زبانآموزان سطح متوسط انگلیسی انتخاب شدند. در گروه شاهد، فعلهای چندقسمتی انگلیسی به روشهای متعارف حفظ و تکرار آموزش داده شدند بدون اینکه دربارة ماهیت استعاری معنای انتزاعی این افعال توضیحی ارائه گردد. در گروه آزمایشی، ماهیت استعاری معنای انتزاعی افعال چندقسمتی ارائهشده و نقش جزء فعلی (حرف اضافة فعل) در برقراری نگاشتهای استعاری میان حوزة مبدأ و مقصد معنای این دسته از فعلها به صورت آشکار توضیح داده شد. هر دوی این گروهها در یک آزمون اولیه و یک آزمون نهایی جامع شرکت کردند تا توانایی آنها در درک معنی افعال ارائه شده بر اساس روشهای آموزشی که بر آنها اعمال شده بود با هم مقایسه گردد. نتایج بررسی نشان داد که در آزمون نهایی، گروه آزمایشی به میزان معناداری بهتر از گروه شاهد عمل کرده است؛ بنابراین نتایج حاصل از این تحقیق کاراتر بودن روش آگاهیبخشی دربارة استعارة مفهومی مبتنی بر یافتههای زبانشناسی شناختی را تقویت میکند.
- چکیده انگلیسی: The ability to comprehend and produce phrasal verbs, as lexical chunks or groups of words which are commonly found together, is an important part of language learning. This study investigates the effect of Conceptual Metaphor Awareness, as a newly developed technique in Cognitive Linguistics, on learning phrasal verbs by Iranian intermediate EFL learners. To meet this objective, two groups of Iranian intermediate EFL learners were included. In the control group, the phrasal verbs were presented with traditional methods of repetition and memorization without giving any explicit explanation about the metaphorical nature of the meaning of phrasal verbs. In the experimental group, the phrasal verbs were presented with an explicit emphasis on the metaphorical nature of the meanings of phrasal verbs contributed by their particles. Both groups took a comprehensive pre-test; another comprehensive test was given to the subjects at the end of the study, in order to investigate the performance of the subjects in the two groups in terms of guessing the meanings of the phrasal verbs based on the instructional methods they had been provided with. The results showed that the experimental group had significantly outperformed the control group; accordingly the outcome of this study let out positive results on teaching phrasal verbs with cognitively oriented methods like conceptual metaphor awareness.
- انتشار مقاله: 21-11-1395
- نویسندگان: Hossein Ghorbanian,Mahdi Safaei Ghalati,َAlireza Amini
- مشاهده