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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Cytokine,Colorectal cancer,Colon,Tumor,immunohistochemistry
- چکیده:
- چکیده انگلیسی: Background: Several studies indicate that chemokines play important roles in colorectal mucosal immunity.
The chemokine CXCL5 which is expressed by epithelial cells within colorectal mucosa is a promoter of cell proliferation,
migration and invasion, is a novel serum prognostic marker in patients with colorectal cancer. The purpose of this study
was to investigate whether serum and tissue CXCL5 levels is altered in colorectal carcinomas (CRC) compared to colonic
adenoma and normal mucosa.It also aimed to compare colon adenoma and colorectal cancer for blood CXCL5 and
CEA levels, their sensitivity, and specificity. Methods: CXCL5 expression was assessed with immunohistochemistry
staining in biopsy samples taken during colonoscopy in 22 colonic adenomas, 23 colorectal carcinomas and 23 normal
colonic tissue samples. Also all patients’ serum CXCL5 and CEA levels were measured. This stduy was prospective
observational study. Results: The number of cases who were stained positive with immunohistochemistry was found to
be higher in the group with CRC. When compared with the other groups, both levels of serum CXCL5 and CEA were
significantly high in the group CRC. Sensitivity and specificity of serum CXCL5 were found to be low as a result of
the ROC analysis. Conclusion: Although the level of CXCL5 is high in CRC, its level in serum is not significant
enough to support the early diagnosis of the disease.- انتشار مقاله: 19-07-1396
- نویسندگان: Kadir Yildirim,Elif Colak,Recep Aktimur,Seda Gun,Mehmet Hakan Taskın,Adil Nigdelioglu,Sude Hatun Aktimur,Filiz Karagöz,Nuraydin Ozlem
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Breast cancer,CerbB2,Estrogen Receptor,Progesterone Receptor,Neutrophil/lymphocyte ratio (NLR)
- چکیده:
- چکیده انگلیسی:
Background: Breast cancer is a heterogeneous complex of diseases comprising different subtypes that have different treatment responses and clinical outcomes. Systemic inflammation is known to be associated with poor prognosis in many types of cancer. The neutrophil / lymphocyte ratio (NLR) and platelet / lymphocyte ratio (PLR) are factors used as indicators of inflammation. In this study, we evaluated NLR and PLR ratios in breast cancer subtypes. Methods: A total of 255 breast cancer patients were evaluated retrospectively. Patients were classified into three subtypes: estrogen receptor (ER)- or progesterone receptor (PR)-positive tumors were classified as luminal tumors; human epidermal growth factor receptor-2 (HER2)-overexpressed and ER-negative tumors were classified as HER2-positive tumors; and ER, PR, and HER2-negative tumors were classified as triple-negative tumors. The NLR and PLR were calculated. Results: The median NLR and PLR were 3 (0.37–37,1) and 137 (37.1–421.3), respectively. 66.7% of the patients were luminal type, 19.2% were HER2 positive, and 14.1% were triple negative. NLR was not associated with grade (p: 0.412), lymphovascular invasion (p: 0.326), tumor size (p: 0.232) and metastatic lymph node involvement (p: 0.406). PLR was higher in the patients with lymph node metastasis than in those without lymph node metastasis (p: 0.03). The NLR was 2 in the luminal group, 1.8 in the HER2-positive group, and 1.9 in the triple-negative group, but the differences were not significant(p: 0.051). PLR was 141 in the luminal group, 136 in the HER2-positive group, and 130 in the triple-negative group, but the differences were not significant. Conclusion: We could not find any significant differences for NLR and PLR according to breast cancer subtypes.- انتشار مقاله: 31-02-1396
- نویسندگان: Ozlem Yersal,Süleyman Çetinkünar,Recep Aktimur,Mehmet Aziret,Sabri Özdaş,Hasan Erdem,Kadir Yildirim
- مشاهده