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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Helicobacter pylori,CYP2C19 genotype,antibiotic resistant strain
- چکیده:
- چکیده انگلیسی: Background: H. pylori is a class I carcinogen and major cause of gastric cancer. Few previous studies reported
relationship between H. pylori infection, CYP2C19 genotype and functional dyspepsia (FD) subtype. The aim of this
study was to determine relationship between CYP2C19 genotype and FD subtype patients(host factor) with antibiotic
resistant strains of H. pylori infection and CagA genotype(bacterial factor). Methods: FD patients who were investigated
with gastroscopy at Thammasat University Hospital, Thailand during March 2017-November 2017 were enrolled. Two
antral gastric biopsies were obtained for rapid urease test, E-test and cultures. CagA genotypes (CagA1a and CagA2a)
were determined by PCR and CYP2C19 genotype was determined by PCR-RFLP. FD patients were categorized as
epigastric pain syndrome(EPS) and postprandial distress syndrome (PDS). Results: 93 FD patients with H. pylori
infection were enrolled (37 male, 56 female, mean age 54.5 years). There were 33 patients with EPS and 60 patients
with PDS. CYP2C19 genotype revealed 55.9% rapid metabolizer (RM), 40.9% intermediate metabolizer (IM) and
3.2% poor metabolizer (PM) genotypes. Antibiotics susceptibility tests demonstrated 62.8% resistant to metronidazole,
12.9% resistant to clarithromycin and 27.1% resistant to fluoroquinolone. CagA 1a and CagA 2a were demonstrated
in 6 patients(11.5%) and 46 patients(88.5%). CagA2a genotype was more prevalent in PDS than EPS patients
(94.3%vs.76.5%; P =0.08) without significance. In intermediate metabolizer (IM), CagA2a genotype was significant
higher in PDS than EPS(100% vs.25%; P=0.004). Conclusions: PDS, CYP2C19 RM genotype and CagA 2a gene of
H. pylori infection were the predominant type of FD in Thailand. Metronidazole remain the most common antibiotic
resistant strain of H. pylori infection in FD patients. PDS (host factor) was significantly related to CagA2a genotype
(bacterial factors) only in patients with intermediate metabolizer. Appropriate dose of proton pump inhibitor (PPI) and
correct regimens for H. pylori eradication in FD patients should be consider to improve clinical outcomes.- انتشار مقاله: 21-09-1397
- نویسندگان: Jeerayuth Auttajaroon,Peranart Chotivitayatarakorn,Yoshio Yamaoka,Ratha-Korn Vilaichone
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Helicobacter pylori,Gastritis,Gastric cancer,peptic ulcer disease,Southeast Asia
- چکیده:
- چکیده انگلیسی: Background: Helicobacter pylori (H. pylori) infection is currently considered as an infectious disease irrespective of
symptoms and stage of disease. This study aimed to survey the impact of H. pylori infection and the current management
approaches in Southeast Asian countries. Materials and methods: This is a survey among 26 experts from 9 Southeast
Asian countries (Cambodia, Indonesia, Laos, Malaysia, Myanmar, Philippines, Singapore, Thailand and Vietnam),
who attended a meeting to develop the ASEAN consensus on H. pylori management in November 2015. Results: The
prevalence of H. pylori varied significantly from 20% to 69% among countries, highest in Myanmar and lowest in
Malaysia. The rate of H. pylori infection in patients with gastritis, peptic ulcer disease and gastric cancer (GC) also
varied significantly, not only among countries but also among regions within the same country. The most common
method for H. pylori diagnosis before treatment was rapid urease test, followed by urea breath test. In multi-ethnic
countries, some ethnic groups including Chinese, Batak and Minahasanese were considered as having higher risk of
GC. There have been no national screening programs for GC in all countries, and a majority of patients with GC were
diagnosed in advanced stages with very poor 5-year survival. Conclusions: The prevalence of H. pylori infection and
its infection rates in related gastrointestinal diseases were significantly different among Southeast Asian countries. The
prognosis of patients with GC in the region was very poor. The result of this survey is a platform for future international
and regional research collaboration.- انتشار مقاله: 08-03-1397
- نویسندگان: Duc Trong Quach,Ratha-korn Vilaichone,Khien Van Vu,Yoshio Yamaoka,Kentaro Sugano,Varocha Mahachai
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Thailand,Hepatocellular carcinoma,ruptured
- چکیده:
- چکیده انگلیسی: Objective: Hepatocellular carcinoma (HCC) is the fatal cancer worldwide. Spontaneously Rupture remains
important complication of HCC. The incidence of spontaneous HCC rupture was high in ASEAN but limited studies
were reported. The aim of this study was to evaluate predictors and overall survival of ruptured HCC in tertiary care
center in Thailand. Methods: We conducted a retrospective cohort study of HCC patients aged ≥15 years old during
January 2012-January 2016 and followed up through June 2016 at Thammasat University Hospital, Thailand. All
clinical information, laboratory and radiologic findings were collected from reviewing computer data base of medical
records. Results: 333 patients had completely retrievable information. Of which, 51patients (15.3%) had spontaneous
ruptured HCC. Clinical symptoms with abdominal discomfort and anemic symptoms were significantly higher in
ruptured than non-ruptured HCC groups. (76.47% vs.39.36%: p<0.001, 13.73vs.0.71%, p<0.001). Furthermore, size
of tumors, presences of metastasis and serum AFP>200 ng/mL were significantly higher in ruptured than non-ruptured
HCC groups (10.29cm. vs. 6.47cm. p<0.001, 17.65% vs. 8.16%, p=0.034, 60.78% vs. 36.88%, p=0.001, respectively).
In multivariate analysis, age, abdominal discomfort, anemic symptoms, Child-Pugh score>6 were independent risk
factors of HCC rupture (OR=0.96, 95%CI=0.93-0.99, p=0.02; OR=3.47, 95%CI=1.26-9.6, p=0.016; OR=54.51,
95%CI=7.09-418.89, p<0.001; OR=2.62, 95%CI=1.09-6.31, p=0.031, respectively). 1-year and 2-year survival rates
of ruptured HCC were 66.9% and 44.6% respectively. Conclusions: Age, abdominal discomfort, anemic symptoms
and Child-Pugh score>6 might be predictive factors of spontaneous ruptured HCC. Ruptures of HCC remained a fatal
disease with poor survival rate in Thailand. Appropriate treatment in early stage could be effective tool to improve the
treatment outcomes- انتشار مقاله: 28-04-1397
- نویسندگان: Jitrapa Kerdsuknirun,Virunpat Vilaichone,Ratha-Korn Vilaichone
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Thailand,Hepatocellular carcinoma,Variceal bleeding
- چکیده:
- چکیده انگلیسی: Objective: Hepatocellular carcinoma (HCC) is common cancer in ASEAN. Variceal bleeding (VB) is considered
to be fatal complication of cirrhosis with HCC. However, limited studies were reported in ASEAN. Aim of this study
was to evaluate overall survival rate and predictors of VB in HCC patients. Methods: We conducted a retrospective
cohort study of HCC patients aged ≥15 years between January 2012-January 2016 and follow up through June 2016 at
Thammasat University Hospital, Thailand. Clinical information and radiologic findings were collected from reviewing
computer database of medical records. Results: 333 patients had completely retrievable information. Of which, 27
patients (8.1%) had documented with VB. Clinical presentations with weight loss and jaundice were higher in VB than
non-VB groups (40.74% vs. 34.64%, p=0.525 and 7.41% vs. 2.29%, p=0.116) but the differences were not significant.
The most common causes of cirrhosis in HCC patients with VB were chronic HBV infection (55.56%). In multivariate
analysis; presence of ascites, Child-Pugh score>6, presence of varices were independent risk factors of having VB in
HCC patients (OR=7.59, 95%CI=1.13-50.88, p=0.037; OR=5.07, 95%CI=1.08-23.76, p=0.039; OR=23.51, 95%CI=4.71-
117.35, p<0.001, respectively). In HCC patients with VB, 1-year and 2.5-year survival rates were 56.6% and 28.3%.
Conclusions: HCC patients with ascites, Child-Pugh score>6 and presence of varices might be important predictive
factors of VB. Having VB were greatly impact to the survival rate of HCC patients. Clinical suspicion and regular
surveillance of VB in HCC patients at risk could improve treatment outcomes.- انتشار مقاله: 03-05-1397
- نویسندگان: Jitrapa Kerdsuknirun,Virunpat Vilaichone,Ratha-Korn Vilaichone
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Antibiotic resistant,Helicobacter pylori,ASEAN
- چکیده:
- چکیده انگلیسی: Objective: Antibiotic resistance has significantly impact on eradication rates for H. pylori infection and remains
important cause of treatment failure worldwide including ASEAN countries. The aim of this study was to survey
the prevalence and antibiotic resistant pattern of H. pylori infection in ASEAN. Methods: This study was a survey among
26 experts from 9 ASEAN countries including Thailand, Cambodia, Indonesia, Laos, Malaysia, Myanmar, Philippines,
Singapore and Vietnam whom attended a meeting to develop the ASEAN consensus on H. pylori management in Bangkok
in November 2015. A questionnaire was sent to each member of the consensus meeting. The detail of the questionnaire
included information about prevalence of H. pylori infection, facilities to perform H. pylori culture, molecular testing
for antibiotic resistance and antibiotic resistance rate in their countries. Results: H. pylori infection remain common
in ASEAN ranging from 20% in Malaysia, 21-54% in Thailand and 69% in Myanmar. Most of ASEAN countries
can perform H. pylori cultures and antibiotic susceptibility tests except Laos and Cambodia. In ASEAN countries,
metronidazole resistant H pylori is quite common whereas amoxicillin resistance remain rare. Clarithromycin resistance
results in a significant decrease in H. pylori eradication rate with clarithromycin-containing regimens. The prevalence of
clarithromycin resistance varies in ASEAN countries being high in Vietnam (30%) and Cambodia (43%), moderate to high
in Singapore (17%) and low in Malaysia (6.8%), Philippine (2%) and Myanmar (0%). In Thailand, clarithromycin
resistance tends to higher in large cities (14%) than in rural areas (~3.7%). Conclusion: ASEAN countries should
develop a standard protocol for regular susceptibility testing of H. pylori so that clinicians would be better able to
choose reliably effective empiric therapies. The wide range of antibiotic resistance in ASEAN countries suggests that
the preferred first line regimen should be depend on the local antibiotic resistance other than single recommendation.- انتشار مقاله: 30-11-1396
- نویسندگان: Ratha-Korn Vilaichone,Duc Trong Quach,Yoshio Yamaoka,Kentaro Sugano,Varocha Mahachai
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Colorectal cancer,Ulcerative colitis,Thailand
- چکیده:
- چکیده انگلیسی:
Background: Ulcerative colitis(UC) is important risk factor of colorectal cancer. Many evidences from western countries confirmed this relationship but limited studies were reported in ASEAN. This study was aimed to investigate prevalence, clinical presentations, endoscopic findings, histopathology, disease progression and risk for colorectal cancer(CRC) of UC patients in Thailand. Methods: We conducted a retrospective cohort study using computer data base from Thammasat University Hospital, Pathumthani, Thailand between September 2011 and December 2015, follow-up through May 2016. Diagnosis of UC was confirmed by histopathology and whole clinical course. Results: We identified 6,082 patients who diagnosed with colitis during the study period. Of whom, only 22 patients(<1%) was confirmed of UC. Male to female ratio was 13:9 (mean age of 47.2 years). Clinical presentations were bloody diarrhea in 86.4%, watery diarrhea in 31.8% and abdominal pain in 59.1%. According to Montreal classification, disease extensions were ulcerative proctitis in 22.7%, distal UC in 50%, and pancolitis in 27.3%. Disease grading was mild in 31.8%, moderate in 9.1%, and severe in 59.1%. The prevalence of precancerous lesions were 2/22 patients(9.1%). There was no definite invasive colorectal cancer patient during study period. However, history of malnutrition was significantly higher in patients with dysplasia than those without dysplastic lesions(50%vs.0%, P-value=0.045). There was no difference in duration and disease extension between 2 groups. Interestingly, subgroup analysis demonstrated that pancolitis was significantly more common in female than male(55.6%vs.7.7%,P-value=0.02,OR=15.0, 95%CI=1.3-169.9). Furthermore, patients’ age> 35 years had significantly more severe colitis than younger group (81.25%vs.0%, P-value=0.0006) Conclusions: Although UC is rare disease in ASEAN, precancerous lesions for CRC were not uncommon. UC with pancolitis was common in female whereas severe colitis was common in elderly patients. Proper screening program and careful surveillance for precancerous lesions in patients at risk might be appropriate approach for early detection and improvement the treatment outcome.- انتشار مقاله: 20-12-1395
- نویسندگان: Peranart Chotivitayatarakorn,Ratha-Korn Vilaichone
- مشاهده