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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Journal of Chemical Reviews
- نوع مقاله: Journal Article
- کلمات کلیدی: Multicomponent reactions,Arylglyoxals,Pyrrolo[2,3-d]pyrimidines,Enamines
- چکیده:
- چکیده انگلیسی: This review provides an overview of the recent literature on application of arylglyoxals the synthesis of pyrrolo[2,3-d]pyrimidines via multicomponent reactions in the period of 2008–2018. 1,2-Dicarbonyl compounds are attractive precursors for synthesis of various heterocyclic compounds, and arylglyoxals are frequently applied in synthesis of various organic compounds, and in particular of pyrrolo[2,3-d]pyrimidines derivatives, which are important due to their biological and pharmaceutical activities.
- انتشار مقاله: 27-04-1398
- نویسندگان: Ramin Javahershenas,Jabbar Khalafy,Rolf Herman Prager
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Journal of Green Chemistry
- نوع مقاله: Journal Article
- کلمات کلیدی: β-Aminocrotonitrile Arylglyoxal 1,3-Dimethylbarbituric acid Thiobarbituric acid TEA (triethylamine)
- چکیده:
- چکیده انگلیسی: A green approach to synthesis of the polyfunctionalized pyrazole [4′,3′:5,6]pyrido[2,3-d] pyrimidines derivatives was successfully achieved via one-pot, four component reactions of β-aminocrotonitrile, phenyhydrazine, arylglyoxals, barbituric acid derivatives in the presence of TEA (Triethylamine) as a catalyst in water under the reflux conditions. This protocol provided mild reaction conditions, short reaction times, high yields, low cost, easy isolation of products and possible biological, and pharmaceutical activities.
- انتشار مقاله: 15-12-1396
- نویسندگان: Ramin Javahershenas,Jabbar Khalafy
- مشاهده