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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Iranian Journal of Pathology
- نوع مقاله: Journal Article
- کلمات کلیدی: methylation,Tumor suppressor genes,Papillary thyroid cancers
- چکیده:
- چکیده انگلیسی: Background & Objective:
Papillary thyroid cancer (PTC) is considered to be the most common type of thyroid malignancies. Epigenetic alteration, in which the chromatin conformation and gene expression change without changing the sequence of DNA, can occur in some tumor suppressor genes and oncogenes. Methylation is the most common type of epigenetic alterations that can be an excellent indicator of PTC invasive behavior.
Methods:
In this research, we determined the promoter methylation status of four tumor suppressor genes (SLC5A8, RASSF1, MGMT, and DNMT1) and compared the results of 55 PTC cases with 40 goiter patients. For methylation, we used the methylation-sensitive high resolution melting (MS-HRM) assay technique. The resulting graphs of each run were compared with those of 0%, 50%, and 100% methylated controls.
Result:
Our data showed that the promoter methylation of SLC5A8, Ras association domain family member 1(RASSF1), and MGMT were significantly different between PTC tissue and goiter with P-value less than 0.05. The most significant differences were observed in RASSF1; 77.2% of hyper-methylated PTC patients versus 15.6% hyper-methylated goiter samples (P<0.001).
Conclusion:
RASSF1 promoter methylation can be a PTC genetic marker. RASSF1 promoter methylation is under the impact of the methyltransferase genes (DNMT1 and MGMT), protein expression, and promoter methylation.- انتشار مقاله: 03-07-1397
- نویسندگان: Fatemeh Khatami,Bagher Larijani,Ramin Heshmat,Shirzad Nasiri,Hiva Saffar,Gita Shafiee,Azam Mossafa,Seyed Mohammad Tavangar
- مشاهده
- جایگاه : پژوهشی
- مجله: International Journal of Pediatrics
- نوع مقاله: Journal Article
- کلمات کلیدی: children,adolescents,Inequality,Healthy foods,Junk foods
- چکیده:
- چکیده انگلیسی: Background: Nutritional habits and its determinants, especially in children and adolescents have recently turned into the one of the major concerns of health researches. We examine the diet contribution inequality in according to socio-demographic factors, age, gender, physical activity and body image to alleviate this gap in Iranian children and adolescents.
Materials and Methods: Study sample was comprised of 14,880 students aged 6-18 years who selected from urban and rural districts of 30 provinces of Iran via stratified multi-stage sampling method. A short food frequency questionnaire was used for estimating the food group consumption. The Blinder-Oaxaca method was applied to investigate the inequality in the prevalence of healthy and junk foods consumption between the first and fifth socio-economic status (SES) quintiles.
Results: The frequency of healthy and junk foods consumption showed considerable differences between the SES quintiles. The highest differences were found in the frequency of fresh fruit (25.38%), vegetable (12.92%), and milk (10.74%) consumption, respectively. The daily consumption of vegetables, and fresh and dried fruits increased linearly by increasing the SES quintiles. The highest absolute difference was seen in the frequency of fresh fruit consumption between the bottom and top of the socioeconomic groups (SII value=-32%). The estimated SII was statistically significant for the consumption of all healthy and junk foods except for fast foods and milk consumption. The estimated C index for consumption of healthy and junk foods was positive and negative, respectively.
Conclusion: This study provides the considerable information on the consumption of healthy and junk foods and its determinants among Iranian children and adolescents for better programming, developing health policies, and future complementary analyses.- انتشار مقاله: 28-09-1397
- نویسندگان: Kumars Pourrostami,Mostafa Qorbani,Ramin Heshmat,Fatemeh Mohammadi-Nasrabadi,Shirin Djalalinia,Ali Sheidaei,Mohammad Esmaeil Motlagh,Gelayol Ardalan,Armita Mahdavi-Gorabi,Morteza Mansourian,Roya Kelishadi
- مشاهده
- جایگاه : پژوهشی
- مجله: International Journal of Pediatrics
- نوع مقاله: Journal Article
- کلمات کلیدی: Iran,Adolescent,Helicobacter pylori,Metabolic Syndrome
- چکیده:
- چکیده انگلیسی: Background: At least half the world’s population is colonized the stomach by Helicobacter pylori (H. pylori) which are a key constituent of the human microbiome. The aim of this study was to investigate the association of cardiometabolic risk factors with H. pylori infection in Iranian adolescents. Materials and Methods: The current study was conducted along with the third survey of a national school-based surveillance system in Iran, entitled "Childhood and Adolescence Surveillance and Prevention of Adult Non-communicable Disease" (CASPIAN) study. Detailed questionnaires on demographic, socioeconomic, dietary, and health-related information of the participants were filled by one of the parents under supervision of trained health-care workers. Trained healthcare professionals measured anthropometric indices, blood pressures according to standard protocols. Fasting venous blood was examined for fasting blood sugar and lipid profile.
Results: Overall 882 serum samples were suitable for testing. H. pylori antibody was found in 643 serum samples (72.9%). Among cardiometabolic risk factors, only the mean weight of participants was different between two groups (44.6±11.8 in H. pylori positive and 42.8±11.3 in H. pylori negative group; p=0.04). Overall, 5.1% of adolescents with positive H. pylori tests were overweight or obese, while 1.7% of negative ones were so (p=0.02). In the multivariate regression model, H. pyloriseropositivity increased the risk of overweight (OR, 3.3; 95%CI, 1.2-9.3; p= 0.03). In the multivariate model, association of other cardiometabolic risk factors with H. pylori infection was not statistically significant (p>0.05).
Conclusion: Results of present study showed that H. pylori infection was associated with excess weight in adolescents. H. pylori eradication may be decrease the risk of obesity.- انتشار مقاله: 29-03-1396
- نویسندگان: Enayat Kalantar,Mohammand Javad Gharavi,Shervin Ghaffari Hoseini,Ramin Heshmat,Mojgan Oshaghi,Behnaz Gharegozlou,Hamid Asayesh,Armita Mahdavi Gorabi,Mohammad Esmaeil Motlagh,Mehdi Noroozi,Mostafa Qorbani,Roya Kelishadi
- مشاهده
- جایگاه : پژوهشی
- مجله: International Journal of Pediatrics
- نوع مقاله: Journal Article
- کلمات کلیدی: children,Iran,adolescents,Self-Perceived Health,Wellness
- چکیده:
- چکیده انگلیسی:
Background: Health status is an individual’s relative level of wellness and illness. Self-Perceived Health (SPH) is a single item considered as a health indicator for national and international survey. The aim of this study was to evaluate the SPH measure and its determinants in a National sample of Iranian children and adolescents.
Materials and Methods: This National study was performed as the fourth National survey of a school‑based surveillance program entitled the Childhood and Adolescence Surveillance and Prevention of Adult Non-communicable Disease (CASPIAN‑IV) study. 14,880 students aged 6-18 years old selected from 30 provinces of Iran by a multistage Cluster and stratified sampling method. Two sets of valid and reliable questionnaires were completed for students and their parents.
Results : Overall 13,846 participated in the present studywith 90.6 % participation. In this study, 80.5 % of boys and 79.4% of girls reported good SPH (95% confidence interval (CI), 79.3-81.6 versus 78.1-80.6, respectively). According to the living area, 79.5% from urban and 81.1% from rural area declared good SPH (95% CI, 78.6-80.5 versus 79.2-82.8, respectively). In the multivariate model, the subjects who had healthy weight compared with excess weight had significantly higher SPH (OR: 1.36; 95% CI, 1.17-1.59). Also, the subjects with high Socio-economic status (SES) had higher odds of SPH (odds ratio [OR], 1.23; 95% CI, 1.06-1.41).
Conclusion: Our results showed that SPH can be influenced by both demographic and life style related characteristics among study population. This association was stronger for SPH and academic success, talking with both parents and having normal body image respectively.
- انتشار مقاله: 08-01-1396
- نویسندگان: Hoda Zahedi,Ramin Heshmat,Moloud Payab,Gelayol Ardalan,Mohammad Esmaeil Motlagh,Gita Shafiee,Hamid Asayesh,Ali Asghar Ahmadishokouh,Mostafa Qorbani,Roya Kelishadi
- مشاهده
- جایگاه : پژوهشی
- مجله: International Journal of Pediatrics
- نوع مقاله: Journal Article
- کلمات کلیدی: Iran,Helicobacter pylori,Seroprevalence,adolescents
- چکیده:
- چکیده انگلیسی: Background: Helicobacter pylori (H.pylori) is a common bacterial infection, with considerably high morbidity and mortality worldwide. This bacterium represents a key factor in the etiology of various chronic infections ranging from gastritis, peptic ulcer disease to gastric cancer; but the prevalence has large variations in different communities. The aim of this study was to estimate the prevalence H. pylori infection in a nationally representative sample of Iranian adolescents.
Materials and Methods: In this cross-sectional study, serum samples of 882 Iranian adolescents, aged 10-18 years, were examined for seroprevalence of H.pylori. They were randomly selected from the samples obtained in the third survey of a national surveillance program (the CASPIAN III study). Seroprevalence of H. pylori was examined by detection of H. pylori immunoglobulinA (IgA), immunoglobulinG (IgG) and immunoglobulinM (IgM) in sera by using Enzyme Linked Immunosorbant Assay (ELISA).
Results: The study participants had a mean age of 14.82 + 2.77 years. Overall, 51.7% of students were boys and 61.52% were urban residents. The H. pylori IGM and IGA seropositivity had no significant association with demographic characteristics (p>0.05). The H. pylori IgG seropositivity were significantly different in boys and girls (69.7%, 95% confidence interval [CI] = 66.7-72.7 vs. 76.3%, 95%CI= 73.5-79. 1, respectively, P=0.03).
Conclusion: The seroprevalence of H. pylori IgG in Iranian adolescents is high, and girls had greater risk of H. pylori IgG seropositivity compared to boys. Preventive strategies and health education are recommended to reduce the prevalence of this infection in Iranian adolescent.- انتشار مقاله: 13-09-1395
- نویسندگان: Enayatollah Kalantar,Mohammad Javad Gharavi,Mojgan Oshaghi,Behnaz Gharegozlou,Sara Mohammadi,Ramin Heshmat,Shervin Ghaffari Hoseini,Mohammad Esmaeil Motlagh,Mostafa Qorbani,Roya Kelishadi
- مشاهده
- جایگاه : پژوهشی
- مجله: International Journal of Pediatrics
- نوع مقاله: Journal Article
- کلمات کلیدی: Iran,Students,Healthy food,Psychiatric distress,Violent behaviors
- چکیده:
- چکیده انگلیسی: Background: Healthy dietary habits are known as a key factor for improving brain functions and cognitive ability in children and adolescents. The goal of this study was to evaluate the association of healthy food consumption with mental health in Iranian children and adolescents.
Materials and Methods: Data were obtained from the fourth national school-based surveillance survey entitled CASPIAN-IV study. In this study, 14880 children and adolescents aged 6-18 years were selected by multistage, cluster sampling method from rural and urban areas. The students and their parents completed two sets of questionnaires. The psychiatric distress included depression, worry, insomnia, anxiety, aggression, confusion, and worthless and the violent behaviors comprised of physical fight, victim and bully. The healthy foods included fresh fruits, dried fruits, vegetables and dairy products.
Results: The participants include 13,486 students from elementary, intermediate and high school degree. The prevalence of psychiatric distress was significantly higher among high school students, while violent behaviors were more prevalent in the middle school students. According to the multivariate model (model IV), the risk of psychiatric distress was significantly lower in students with daily consumption of fresh fruits, vegetables and milk. In addition, those with daily consumption of vegetables and milk had significantly lower risk for violent behaviors.
Conclusion: Consumption of healthy foods may reduce the risk of psychiatric distress and violent behaviors. Therefore, in addition to its benefits, increasing healthy food consumption among children and adolescents can be useful in preventing mental health disorders.- انتشار مقاله: 08-08-1395
- نویسندگان: Hoda Zahedi,Mostafa Qorbani,Shirin Hasani Ranjbar,Mohammad Esmaeil Motlagh,Gelayol Ardalan,Moloud Payab,Omid Safari,Gita Shafiee,Morteza Mansourian,Ramin Heshmat,Roya Kelishadi
- مشاهده
- جایگاه : پژوهشی
- مجله: International Journal of Pediatrics
- نوع مقاله: Journal Article
- کلمات کلیدی: life satisfaction,self-rated health,Children and adolescents,aggressive behaviors
- چکیده:
- چکیده انگلیسی: Objectives: This study aims to assess the relationship between the frequency of aggressive behaviors, life satisfaction (LS) and self- rated health (SRH) and counseling with family members in a representative sample of Iranian children and adolescents.
Methods: In this nationwide study, 14880 school students, aged 6-18 years, wereselected by cluster and stratified multi-stage sampling method from 30 provinces inIran. The World Health Organization Global School-based Health Survey questionnaire(WHO-GSHS) was used.Mental disorders were assessed through the WHO-GSHSquestionnaire that consisted of worthless, angriness, anxiety, insomnia, confusion, depression, and worried.
Results:.The results showed that 45.7% of boys and 44.8% of girls share their problem with their brother or sister. The prevalence of physical fight, victim, and bully was not different in children and adolescents who consulted with their brother or sister compared with those who did not consult (p> 0.05). In addition, 60.4% of boys and 66.0% of girls share their problems with friends. Physical fight and bully were less prevalent in children and adolescents who consulted with their friends compared with those who did not consult (p< 0.001). According to this study, the prevalence of LS and SRH “good” was also lower in children and adolescents who share their problem with their father or mother compared with those who did not consult (p< 0.001).
Conclusion:Children and adolescents should be encouraged to consult with their parents about their problems. Parents should offer their children an opportunity to express their views and wishes about their problems.- انتشار مقاله: 04-05-1395
- نویسندگان: Hossein Ansari,Ramin Heshmat,Mohsen Jari,Mostafa Qorbani,Mehrdad Kazemzadeh Atoofi,Shirin Djalalinia,Mohammad Esmaeil Motlagh,Elham Samami,Mojtaba Keikha,Asal Ataie-Jafari,Omid Safari,Morteza Mnaourian,Roya Kelishadi
- مشاهده
- جایگاه : پژوهشی
- مجله: International Journal of Pediatrics
- نوع مقاله: Journal Article
- کلمات کلیدی: children,mental disorders,Behavior problems,Meal frequency,Meal skipping
- چکیده:
- چکیده انگلیسی: Background: This study aimed to assess the relationship between meal frequency with mental distress and violent behavior among a nationally representative sample of Iranian children and adolescents.
Materials and Methods: The participants of this national study were 14,880 Iranian students with 6 to 18 years of age. They were selected from urban and rural regions of Iran by multi-stage cluster sampling method. The data were obtained about demographic information, mental distress, violent behaviors and meal frequency by the questionnaire of the World Health Organization-Global School-based Student Health Survey (WHO-GSHS).
Results: The response rate was 90.6%. The participants who were categorized as the group eating 3 meals per week significantly experienced less mental distress than those who were categorized as consuming 2 meals and one/no meal per week (P-value < 0.05). The min rate of violent behaviors was observed among participants who were classified as consuming 3 meals group and the max rate in one/no meal group. Participants who were categorized as consuming one/ no meal and 2 meals per week had higher risk of mental distress and violent behaviors compared with those whom consumed 3 meals per week.
Conclusions: Meal skipping was significantly associated with mental problems and violent behaviors among Iranian children and adolescents and this association was independent of known confounders.- انتشار مقاله: 17-04-1395
- نویسندگان: Hossein Ansari,Roya Kelishadi,Mostafa Qorbani,Morteza Mansourian,Zeinab Ahadi,Mohammad Esmaeil Motlagh,Gelayol Ardalan,Saeid Safiri,Hamid Asayesh,Rasool Mohammadi,Ramin Heshmat
- مشاهده
- جایگاه : پژوهشی
- مجله: International Journal of Pediatrics
- نوع مقاله: Journal Article
- کلمات کلیدی: Adolescent,Overweight,Obesity,Child,Food habits
- چکیده:
- چکیده انگلیسی: Background: Obesity has a growing global epidemic with several risk factors including lifestyle habits, physical activity, and prolonged screen time. This study aimed to compare the dietary habits and self-reported health behaviors in a nationally representative sample of Iranian children and adolescents.
Materials and Methods: This cross sectional nationwide study was conducted in the framework of the fourth survey of a national school-based surveillance program, entitled Childhood and Adolescence Surveillance and Prevention of Adult Non‑communicable disease (CASPIAN-IV) Study. Participants were 14,880 students aged 6-18 years from 30 provinces in Iran. The World Health Organization- Global Student Health Survey questionnaire was utilized to assess their relationship with peers, body image, dietary, life-style and smoking habits, physical activity, and violence behaviors. Apart from the questionnaire, additional information on dietary habits was obtained as well. The Chi-square test and the student t-test were used to compare the groups.
Results: Boys had higher proportions of obesity (P<0.05). The prevalence of overweight and obesity decreased with age. Intake of refined bread (NS), non-hydrogenated oils (P<0.001), and low fat dairies (P<0.05) predominated in all three BMI categories. Meal skipping was less prevalent compared to planned meals, but there was an increasing trend according to BMI. All three BMI categories, were watching TV more than 2 hours per day (P<0.05). Depression and fighting were more prevalent in overweight and obese individuals, respectively.
Conclusion: Unhealthy food intake and dietary habits were prevalent in all BMI categories, while poor health related behaviors were more seen in children with higher weight.- انتشار مقاله: 09-03-1395
- نویسندگان: Fatemeh Azizi-Soleiman,Mohammad Esmaeel LMotlagh,Mostafa Qorbani,Ramin Heshmat,Gelayol Ardalan,Morteza Mansourian,Roya Kelishadi
- مشاهده
- جایگاه : پژوهشی
- مجله: International Journal of Pediatrics
- نوع مقاله: Journal Article
- کلمات کلیدی: Iran,Vitamin D deficiency,Climate,Children and adolescents
- چکیده:
- چکیده انگلیسی: Background: Sunlight is the main source of vitamin D; therefore, environmental factors might have an important role in the high prevalence of hypovitaminosis D in children. This study aimed to assess the vitamin D status according to the climate of the living area in a nationally representative sample of Iranian adolescents.
Material and Methods: This nationwide cross-sectional survey was performed among a representative sample of 1,095adolescents aged 10-18 years, selected by multistage cluster sampling method from 27 provinces of Iran. Serum 25-hydroxyvitamin D [25(OH) D] concentrations was compared in inhabitants of humid-rainy, cold-mountainous, and sunny regions.
Results: Vitamin D deficiency was documented in 40% of participants including 40.70% of boys and 39.30% of girls. We found significant difference in 25(OH) D concentrations among participants living in the three different climates of the living area (P<0.05). The median inter-quartile range (IQR) level for 25(OH)D was lower in humid-rainy climate: 11.40 (18.64). Hypovitaminosis D was more frequent in humid-rainy climate (42.30%), compared to other climates; this difference was more prominent in urban areas (P<0.05). Boys living in various climates had significantly different levels of 25(OH) D(P<0.05), however this figure was not significantly different for girls (P>0.05). The highest frequency of hypovitaminosis D (45.2%) was documented among boys living in humid-rainy regions.
Conclusion: The high prevalence of hypovitaminosis D, notably among inhabitants of humid-rainy region underscores the necessity of implementing national preventive strategies. This is of great importance especially in regions with lower exposure to sunlight.- انتشار مقاله: 18-01-1395
- نویسندگان: Roya Kelishadi,Mostafa Qorbani,Mohammad Esmaeil Motlagh,Ramin Heshmat,Parinaz Poursafa,Maryam Bahreynian
- مشاهده