در هنگام جستجو کلمه در قسمت عنوان میتوانید کلمات مورد جستجو را با کاراکتر (-) جدا کنید.
کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Journal of Research in Weed Science
- نوع مقاله: Journal Article
- کلمات کلیدی: Ageratum conyzoides,Alternanthera,Phytosociological analysis,Weed shift
- چکیده:
- چکیده انگلیسی: Over centuries, agricultural practices have undergone the transition from extensive and traditional to intensive and specialized. Thus, the weeds colonizing cultivated fields are subjected to major shifts due to increased use of herbicides, fertilizers and tillage. There are a total of 176 weed species in Agro-ecosystems of Himachal Pradesh and not less than 46 in maize. Weeds, in maize, are hardier in nature and compete with the crop significantly reducing its yield. Also, slow initial growth and wider spacing favour the growth of weeds even before crop emergence. Commelina benghalensis, Ageratum conyzoides, Echinochloa colona, Panicum dichotomiflorum, Cyperus iria, Digitaria sanguinalis, Polygonum alatum and Aeschynomene indica were dominant weeds observed under Kangra district conditions of Himachal Pradesh. The phytosociological study showed that the species which invaded the non-cropped lands are increasingly infesting the cultivated fields. In 2008, most abundant weed was Fimbristylis miliacea followed by Cyperus difformis, Eragostis tennela, Ageratum conyzoides, Ammannia baciferra, Bidens pilosa and Hackelia uncinata. In 2018, Ageratum conyzoides was the most abundant followed by Phyllanthus niruri, Panicum dichotomiflorum, and Commelina benghalensis. Ageratum conyzoides was the most important weed in 2008 followed by Echinochloa colona, Fimbristylis miliacea, and Digitaria sanguinalis, in that order. The Important Value Index (IVI) for individual weed species in the maize field crop in 2018 indicated that Ageratum conyzoides was again the most important weed species followed by Phyllanthus niruri, Echinochloa colona, Alternanthera philoxeroides, Aeschynomene indica, Commelina benghalensis and Digitaria sanguinalis. The weed species viz. Ammannia baccifera, Bidens pilosa, Brachiaria ramose, B. reptans, Dactyloctenium aegyptium, Fimbristylis miliaceaum, Galinsoga parviflora, Hackelia uncinata, Ipomoea pestgridis, and Physalis minima those recorded in 2008 were not found in the survey of 2018. Aeschynomene indica, Alternanthera philoxeroides, Amaranthus viridis, Echinochloa crusgalli and Oxalis sp. recorded during 2018 were not found in the survey of 2008.
- انتشار مقاله: 09-12-1397
- نویسندگان: Surinder Singh Rana,Rahul Sharma,Akashdeep Singh,Suresh Kumar
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: MMR,CML,imatinib
- چکیده:
- چکیده انگلیسی:
Background and objectives: Imatinib mesylate is approved for the treatment of Chronic Myeloid Leukemia (CML). About 20% of patients with CML do not respond to treatment with Imatinib either initially or because of acquired resistance. In addition to mutated BCR-ABL1 kinase, the organic cation transporter1 (OCT1, encoded by SLC22A1) has been considered to contribute to Imatinib resistance in patients with chronic myeloid leukemia (CML). OCT1 has been reported to be the main influx transporter involved in Imatinib uptake into CML cells. To date, only a few studies have been reported on involvement of influx transporters in development of Imatinib resistance. Therefore this study was aimed to determine the expression level of Imatinib uptake transporter (OCT1) in CML patients and to correlate this level with molecular response. Methods: One hundred fifty eight patients on Imatinib were considered for gene expression analysis study for OCT1 gene. Total RNA was extracted from peripheral blood mononuclear cells. Complementary DNAs (cDNAs) were synthesized and Real Time Polymerase Chain Reaction (RQ-PCR) was performed. Results: High OCT1 expression was present in 81 (51.8%) patients and low OCT1 expression was in 77 (48.7%) patients. Low Sokal risk score group have a significantly high OCT1 expression (p=0.048). The rate of molecular response was higher in those with high OCT1 expression than in those with low OCT1 expression (p=0.05). Both event-free survival and median overall survival were significantly shorter in patients with low OCT1 expressions when compared to the patients with high OCT1 expression (p=0.03 and p=0.05). Conclusions: Our findings demonstrated that the mRNA expression level of OCT1 was significantly correlated with molecular response in CML patients. Based on these findings, present study believes that the pre-therapeutic higher expression of OCT1 may help to predict response to imatinib therapy in CML patients.- انتشار مقاله: 25-09-1395
- نویسندگان: Sunita Chhikara,Sudha Sazawal,Tulika Seth,Rekha Chaubey,Kanwaljeet Singh,Rahul Sharma,Pravas Mishra,Manaranjan Mahapatra,Renu Saxena
- مشاهده