در هنگام جستجو کلمه در قسمت عنوان میتوانید کلمات مورد جستجو را با کاراکتر (-) جدا کنید.
کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Asian Journal of Green Chemistry
- نوع مقاله: Journal Article
- کلمات کلیدی: Breast cancer,Synthesis,Steroid,Derivatives,Docking
- چکیده:
- چکیده انگلیسی: Several compounds have been prepared to treatment of breast cancer; however, some of these drugs may produce some side effects. The aim of this study is to synthesize two new steroid derivatives (Compounds 7 or 8) to evaluate their theoretical interaction with a breast cancer protein (BRCA-1) using a docking model. The preparation of 7 and 8 was carried out using a series of reactions which involves; (i) addition/cyclization; (ii) amination, (iii) etherification and (iv) esterification. Chemical structure of the compounds was confirmed using elemental analysis and NMR spectrum. The following stage involved the theoretical evaluation on the interaction of both compounds 7 or 8 with BRCA-1 protein surface using a docking model. The results showed that compound 7 could bound to different type of amino acid residues of BRCA-1 protein compared with 8; this phenomenon, may exert changes in the biological activity of BRCA-1 protein. All data suggest that compound 7 or 8 could be an alternative therapeutic for treatment of the breast cancer.
- انتشار مقاله: 21-05-1397
- نویسندگان: Figueroa-Valverde Lauro,Diaz-Cedillo Francisco,Rosas-Nexticapa Marcela,Mateu-Armand Virginia,Montano-Tapia Elizabeth,Hau-Heredia Lenin,Lopez-Ramos Maria,García-Cervera Elodia,Pool-Gómez Eduardo,Cauich-Carrillo Regina,Alfonso-Jimenez Alondra,Cabrera-Tuz Jhaira
- مشاهده