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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Survival,Prognostic Value,Ovarian Cancer,PD-L1 expression,Immunotherapy
- چکیده:
- چکیده انگلیسی: Objective: To examine the expression of programmed death ligand 1 (PD-L1) in type I and type II epithelial
ovarian cancers (EOC) and its associations with outcomes. Methods: Records of 132 women with EOC were reviewed.
Immunostaining of PD-L1 was performed with formalin-fixed, paraffin-embedded specimens. Expression of PD-L1 was
classified into four categories (0; 1+; 2+; 3+) according to intensity of expression. Expression of PD-L1 ≥2+ was deemed
to be high. Results: Of the 132 women, 75 (56.8%) and 57 (43.2%) women had type I and type II tumors, respectively.
Approximately 70% of cases exhibited high PD-L1 expression. There was no significant difference in the rate of high
PD-L1 expression between the two EOC types (65.3% versus 59.6%). In type I tumors, high PD-L1 expression was
associated with more advanced stages (51.0% versus 34.6%), greater recurrence (46.9% versus 26.9%), and shorter
median progression-free survival (27 months versus 62 months) than low expression. In type II tumors, there were no
apparent differences between high and low expression of PD-L1 in terms of the percentage of advanced-stage tumors
(82.6% versus 79.4%), recurrence (56.5% versus 58.8%), and median progression-free survival (21 months versus
24 months). Conclusion: high PD-L1 expression is associated with worse oncological outcomes in type I EOC. This
finding emphasizes the merit of further studies to confirm this promising result and to determine the potential role of
PD-L1 blockade therapy in type I EOC.- انتشار مقاله: 14-07-1397
- نویسندگان: Wilasinee Nhokaew,Pilaiwan Kleebkaow,Nipon Chaisuriya,Chumnan Kietpeerakool
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Overall Survival,Risk Factor,Recurrence-free survival,Endometrial cancer,adenomyosis
- چکیده:
- چکیده انگلیسی: Objective: To determine the effects of uterine adenomyosis on endometrial cancerrecurrence rates. Methods: This
retrospective cohort study reviewed all consecutive patients diagnosed with endometrial cancerwho underwent total
hysterectomy-based surgical staging at Srinagarind Hospital between January, 2010 and January, 2016. The patientswere
divided into two groups:a uterine adenomyosisgroup and a non-adenomyosis group. Patient demographics, type of
surgery, histopathology, stage of endometrial cancer, adjuvant treatment, and survival outcomes were compared.
Results: A total 350 patients were enrolled, with 132 (37.71%) in the adenomyosis group and 218 (62.29%) in the nonadenomyosis group. Deep myometrial invasion and lymphovascular space invasion (LVSI) were more commonly found
among patients who had no adenomyosis compared to those with adenomyosis(52.8% vs 39.4%, P=0.02 and 53.2%
vs. 38.6%, P=0.01). There were no significant differences in terms of five-year recurrence-free survival (HR=1.47;
95%CI 0.88-2.44) and five-year overall survival (HR=0.81; 95%CI 0.43-1.53) between the two comparison groups.
Conclusion: Coexisting uterine adenomyosis in endometrial cancer wasassociated withdeep myometrial invasion and
LVSI but did not have significant impact on survival.- انتشار مقاله: 18-07-1397
- نویسندگان: Sarana Boonlak,Apiwat Aue-Aungkul,Chumnan Kietpeerakool,Pilaiwan Kleebkaow,Bandit Chumworathayi,Sanguanchoke Luanratanakorn,Amornrat Temtanakitpaisan
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: cervical cancer,cervical intraepithelial neoplasia,atypical squamous cell,ASC-H,High-grade squamous intraepithelial lesion
- چکیده:
- چکیده انگلیسی: Objectives: To evaluate prevalence of underlying significant pathologies among women with cervical smears
rated as ‘atypical squamous cells cannot exclude high grade squamous intraepithelial lesion (ASC-H)’, as well as
associated risk factors. Methods: Medical records were reviewed of all consecutive women with ASC-H smears who
had undergone colposcopy at Srinagarind Hospital from January 2008 to July 2016. Significant pathology results
included cervical intraepithelial neoplasia (CIN) 2-3, adenocarcinoma in situ (AIS), endometrial hyperplasia, and
cancer of any original site. Result: During the study period, 133 women with ASC-H were reviewed. The mean age
was 45.3 years (range 21-72). The histopathologic results for the 133 women were as follows: no lesions (58; 43.6%),
CIN 1 (34; 25.6%), CIN 2-3 (33; 24.8%), AIS (2; 1.5%), and cervical cancer (6; 4.5%). The overall rate of significant
pathology was 30.8% (95% confidence interval, 22.9%-38.8%). Women younger than 40 years old carried a higher
risk of harboring significant lesions when compared to older women (41.7% versus 27.8%, respectively). There was
no significant impact of parity and menopausal status on the risk of significant pathology results. Conclusion: The
rate of significant histopathologies among women with ASC-H smears in this study was approximately 31% and the
associated risk factor was patient age.- انتشار مقاله: 28-05-1396
- نویسندگان: Sasivimon Ratree,Pilaiwan Kleebkaow,Apiwat Aue-Aungkul,Amornrat Temtanakitpaisan,Bandit Chumworathayi,Sanguanchoke Luanratanakorn
- مشاهده