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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Iranian Journal of Pharmaceutical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: Iran,Protocols,Inhibitor,Hemophilia,Bypassing agents,Cost components
- چکیده:
- چکیده انگلیسی: Bypassing agents are the most commonly used medicines for the treatment of hemophilia patients with inhibitors. The aim of this study is to identify the cost components of management of bleeding vents in hemophilia patients with inhibitors in Iran.
This study is a cross-sectional study using a bottom-up approach to determine the cost components of treatment of hemophilia patients with inhibitors via ascertaining of all direct medical and non-medical costs.
The evaluating of cost components of 20 patients with 40 episodes of bleeding showed that the price of medicines used is responsible for more than 96% and 97% of costs in treatment of hemophilia patients using FEIBA® and AryoSeven, respectively. The results of this study showed that cost of treating one bleeding episode in hemophilia A patients with high antibody titer using FEIBA is 376 USD compared to 857.3 USD for AryoSeven®.
Despite the small number of hemophilia patients with inhibitor in Iran, due to high cost of treating these patients, it is very important to choose the cost-effective treatment protocol for the treatment of these patients.- انتشار مقاله: 16-12-1394
- نویسندگان: Abdol Majid Cheraghali,Mina Golestani,Peyman Eshghi,Hamidreza Rasekh,Jamshid Salamzadeh,Ali Imani
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Pathology
- نوع مقاله: Journal Article
- کلمات کلیدی: safety,Aryoseven,bleeding disorders
- چکیده:
- چکیده انگلیسی: Background: Recombinant activated factor VII induces hemostasis in patients with coagulopathy disorders. AryoSeven™ as a safe Iranian Recombinant activated factor VII has been available on our market. This study was performed to establish the safety of AryoSeven on patients with coagulopathy disorder. Methods: This single-center, descriptive, cross sectional study was carried out in Thrombus and Homeostasis Research Center ValiAsr Hospital during 2013-2014. Fifty one patients with bleeding disorders who received at least one dose of Aryoseven were enrolled. Patients’ demographic data and adverse effect of drug and reaction related to Aryoseven or previous usage of Recombinant activated FVII were recorded in questionnaires. Finally data were analyzed to compare side effects of Aryoseven and other Recombinant activated FVII brands. Results: Aryoseven was prescribed for 51 Patients. Of all participants with mean age 57.18+21.38 yr, 31 cases were male and 26 subjects had past history of recombinant activated FVII usage. Glanzman was the most frequent disorder followed by congenital FVII deficiency, hemophilia with inhibitors, factor 5 deficiency, acquired hemophilia, hemophilia A with inhibitor, and hemophilia A or B with inhibitor. The majority of bleeding episodes had occurred in joints. Three patients (5.9%) complained about adverse effects of Aryoseven vs. 11.5 % about adverse effects of other brands. However this difference was not significant, statistically. Conclusion: Based on monitor patients closely for any adverse events, we concluded that Aryoseven administration under careful weighing of benefit versus potential harm may comparable with other counterpart drugs. How to cite this article: Toogeh G, Abolghasemi H, Eshghi P, Managhchi M, Shaverdi-niasari M, Karimi K, et al. Evaluation of Aryoseven Safety (recombinant activated factor VII) in patients with bleeding disorders (An observational post-marketing surveillance, study). Iran J Pathol. 2016; 11(3):204-9.
- انتشار مقاله: 23-08-1393
- نویسندگان: Gholamreza Toogeh,Hassan Abolghasemi,Peyman Eshghi,Mohammadreza Managhchi,Mohammadreza Shaverdi-niasari,Katayoon Karimi,Samin Roostaei,Neda Emran,Alireza Abdollahi
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Pathology
- نوع مقاله: Journal Article
- کلمات کلیدی:
- چکیده:
- چکیده انگلیسی:
- انتشار مقاله: 06-07-1393
- نویسندگان: Peyman Eshghi,Hassan Abolghasemi
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی:
- چکیده:
- چکیده انگلیسی: Although successful iron chelation with deferiprone is associated with significant complications, patient’s compliance with medication regimens is of a high priority. The present study did evaluate the complications and compliance of domestically-manufactured deferiprone combined with desferrioxamine for iron chelation therapy. A total of 32 major beta thalassemic patients with cardiomyopathy were enrolled in the study and were monitored clinically and paraclinically. Upon every visit, the patients were prescribed only the number of tablets deemed necessary. The side effects observed as nausea (25%), vomiting (12%), neutropenia (12%), thrombocytopenia (6%), and joint pain (3%) without agranulocytosis or increased liver enzymes to more than twice the normal values. Deferiprone was discontinued in 30% of patients because of severe refractory gastrointestinal complaints (12%), recurrent neutropenia (6%), recurrent thrombocytopenia (6%), severe arthropathy (3%), or interferon therapy (3%). None of the patients, except one, remembered taking full number of the prescribed tablets. Twenty seven patients used 35% to 92% of the prescribed tablets. Poor compliance with deferiprone due to patient’s neglect to take the drug 3 times a day for a prolonged period was the main problem in this regimen. Although thrombocytopenia was more common compared with those of previous reports, other complications were seen with equal or lower frequencies. This study shows that a lower daily dose is the most favorable property of an oral iron chelator for prolonged usage.
- انتشار مقاله: 30-02-1394
- نویسندگان: Peyman Eshghi,Peyman Eshghi,
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: cancer,Adolescent,Psychometrics,sibling,needs assessment
- چکیده:
- چکیده انگلیسی: The sibling cancer needs instrument (SCNI) is the first developed specifically for assessing psychosocial unmet
needs of adolescents having a sibling with cancer. The aim of this study is to evaluate the psychometric properties of its
Persian version. Methods: For this methodological study, the SCNI was translated into Persian using back-translation
and revised according to the comments of the developer of the instrument. Then face validity, content validity, construct
validity, internal consistency and the stability of the Persian version of the instrument were measure, by examining
a population of 180 adolescents having a sibling with cancer in six hospitals in Tehran, Iran. The data were analyzed
using SPSS version 16 and EQS version 6.1. Results: Confirmatory factor analysis approved the construct validity of
the instrument and its seven domains. Cronbach’s alpha was measured as 0.97 for the total instrument and 0.80- 0.92
for its seven domains. In order to evaluate ttest-retest reliability, the intra-class correlation coefficient (ICC) was also
calculated (0.94). Conclusions: The Persian version of SCNI has acceptable psychometric properties. It can be used
for measuring the unmet psychosocial needs in adolescents who have a sibling with cancer in the Persian-speaking
population.- انتشار مقاله: 15-11-1396
- نویسندگان: Zeynab Masoudifar,Leila Khanali Mojen,Maryam Rassouli,Maliheh Nasiri,Pandora Patterson,Fiona Mc Donald,Peyman Eshghi
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: palliative care,Pediatric,regionalization,health system
- چکیده:
- چکیده انگلیسی: Background: Establishing palliative care services is a priority in the health system of Iran. Considering the necessity
of integrating these services into the health system, this study aimed to explore the stakeholders’ perceptions about the
provision of a conceptual framework for palliative care services for children with cancer according to the health system
in of Iran. Methods: The present qualitative study was conducted through in-depth semi-structured interviews held
with 29 participants including palliative care specialists, policy-makers, health care providers, the parents of children
with cancer selected through purposive sampling, between August 2016 and February 2017. Interviews continued
until saturation of data. All interviews were recorded, transcribed and analyzed using MAXQDA10 software. Results:
The codes extracted from interviews produced the main theme “ classes of palliative care services” with the two main
categories “comprehensive care” including, strengthening family shelter, maintaining the child in a familiar environment,
achieving stability and “establishing social justice” including, easy access to services, financial relief and quality care.
Conclusion: Presenting a framework based on level of palliative care services, the findings of this study paves the way
for integrating these services into Iranian health system.- انتشار مقاله: 09-08-1396
- نویسندگان: Leila Khanali Mojen,Maryam Rassouli,Peyman Eshghi,Kazem Zendedel,Ali Akbari Sari,Majideh Heravi Karimooi,Mamak Tahmasebi,Azam Shirin Abadi Farahani
- مشاهده