در هنگام جستجو کلمه در قسمت عنوان میتوانید کلمات مورد جستجو را با کاراکتر (-) جدا کنید.
کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Helicobacter pylori,CYP2C19 genotype,antibiotic resistant strain
- چکیده:
- چکیده انگلیسی: Background: H. pylori is a class I carcinogen and major cause of gastric cancer. Few previous studies reported
relationship between H. pylori infection, CYP2C19 genotype and functional dyspepsia (FD) subtype. The aim of this
study was to determine relationship between CYP2C19 genotype and FD subtype patients(host factor) with antibiotic
resistant strains of H. pylori infection and CagA genotype(bacterial factor). Methods: FD patients who were investigated
with gastroscopy at Thammasat University Hospital, Thailand during March 2017-November 2017 were enrolled. Two
antral gastric biopsies were obtained for rapid urease test, E-test and cultures. CagA genotypes (CagA1a and CagA2a)
were determined by PCR and CYP2C19 genotype was determined by PCR-RFLP. FD patients were categorized as
epigastric pain syndrome(EPS) and postprandial distress syndrome (PDS). Results: 93 FD patients with H. pylori
infection were enrolled (37 male, 56 female, mean age 54.5 years). There were 33 patients with EPS and 60 patients
with PDS. CYP2C19 genotype revealed 55.9% rapid metabolizer (RM), 40.9% intermediate metabolizer (IM) and
3.2% poor metabolizer (PM) genotypes. Antibiotics susceptibility tests demonstrated 62.8% resistant to metronidazole,
12.9% resistant to clarithromycin and 27.1% resistant to fluoroquinolone. CagA 1a and CagA 2a were demonstrated
in 6 patients(11.5%) and 46 patients(88.5%). CagA2a genotype was more prevalent in PDS than EPS patients
(94.3%vs.76.5%; P =0.08) without significance. In intermediate metabolizer (IM), CagA2a genotype was significant
higher in PDS than EPS(100% vs.25%; P=0.004). Conclusions: PDS, CYP2C19 RM genotype and CagA 2a gene of
H. pylori infection were the predominant type of FD in Thailand. Metronidazole remain the most common antibiotic
resistant strain of H. pylori infection in FD patients. PDS (host factor) was significantly related to CagA2a genotype
(bacterial factors) only in patients with intermediate metabolizer. Appropriate dose of proton pump inhibitor (PPI) and
correct regimens for H. pylori eradication in FD patients should be consider to improve clinical outcomes.- انتشار مقاله: 21-09-1397
- نویسندگان: Jeerayuth Auttajaroon,Peranart Chotivitayatarakorn,Yoshio Yamaoka,Ratha-Korn Vilaichone
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Colorectal cancer,Ulcerative colitis,Thailand
- چکیده:
- چکیده انگلیسی:
Background: Ulcerative colitis(UC) is important risk factor of colorectal cancer. Many evidences from western countries confirmed this relationship but limited studies were reported in ASEAN. This study was aimed to investigate prevalence, clinical presentations, endoscopic findings, histopathology, disease progression and risk for colorectal cancer(CRC) of UC patients in Thailand. Methods: We conducted a retrospective cohort study using computer data base from Thammasat University Hospital, Pathumthani, Thailand between September 2011 and December 2015, follow-up through May 2016. Diagnosis of UC was confirmed by histopathology and whole clinical course. Results: We identified 6,082 patients who diagnosed with colitis during the study period. Of whom, only 22 patients(<1%) was confirmed of UC. Male to female ratio was 13:9 (mean age of 47.2 years). Clinical presentations were bloody diarrhea in 86.4%, watery diarrhea in 31.8% and abdominal pain in 59.1%. According to Montreal classification, disease extensions were ulcerative proctitis in 22.7%, distal UC in 50%, and pancolitis in 27.3%. Disease grading was mild in 31.8%, moderate in 9.1%, and severe in 59.1%. The prevalence of precancerous lesions were 2/22 patients(9.1%). There was no definite invasive colorectal cancer patient during study period. However, history of malnutrition was significantly higher in patients with dysplasia than those without dysplastic lesions(50%vs.0%, P-value=0.045). There was no difference in duration and disease extension between 2 groups. Interestingly, subgroup analysis demonstrated that pancolitis was significantly more common in female than male(55.6%vs.7.7%,P-value=0.02,OR=15.0, 95%CI=1.3-169.9). Furthermore, patients’ age> 35 years had significantly more severe colitis than younger group (81.25%vs.0%, P-value=0.0006) Conclusions: Although UC is rare disease in ASEAN, precancerous lesions for CRC were not uncommon. UC with pancolitis was common in female whereas severe colitis was common in elderly patients. Proper screening program and careful surveillance for precancerous lesions in patients at risk might be appropriate approach for early detection and improvement the treatment outcome.- انتشار مقاله: 20-12-1395
- نویسندگان: Peranart Chotivitayatarakorn,Ratha-Korn Vilaichone
- مشاهده