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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: carcinogenesis,cancer biomarkers,Molecular biology
- چکیده:
- چکیده انگلیسی: Background: Protocadherins (PCDHs) have been reported as tumor suppressor genes, implying that these genes may be involved in tumor suppression in a variety of cancers. However, a thorough understanding of the functions and mechanisms of PCDHs remains limited. Our aim was to investigate the methylation profile of PCDHs in human malignant neoplasms. Methods: This systematic review has been recorded in PROSPERO (#42019117844) and conducted according to PRISMA’s checklist; search was conducted in LILACS, PubMed, Science Direct, Scopus, and Web of Science databases, manually, with search queries and without date or language restrictions. Results: We found 91 articles, of which 26 were used for this meta-analysis and categorized according to the origin of the neoplasia. In total, 3,377 cases were compiled, with PCDH10, PCDH17, and PCDH8 being the most studied; males were 2.22 times more affected than females. Studies have shown significant heterogeneity (p <0.001), with the odds ratio varying between cases and controls [2.20 (95% CI = 1.11– 4.35) to 209.05 (95% CI = 12.64– 2,457.18)], and the value of association between methylation and cancers studied was 26.08 (95% CI = 15.42–44.13). Conclusion: In this systematic review, we have demonstrated using meta-analysis that PCDHs could emerge as potential tumor suppressor genes and that a significant increase in methylation may be useful for early detection of different cancers. This work may help in the identification of new prognostic biomarkers in malignant neoplasms.
- انتشار مقاله: 15-05-1399
- نویسندگان: Thaís Torres Barros Dutra,Thâmara Manoela Marinho Bezerra,Ealber Carvalho Macêdo Luna,Francisco Samuel Rodrigues Carvalho,Filipe Nobre Chaves,Paulo Goberlânio De Barros Silva,Fábio Wildson Gurgel Costa,Karuza Maria Alves Pereira
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: smoking,Squamous Cell Carcinoma,Survival analysis,survival rate,oral neoplasms
- چکیده:
- چکیده انگلیسی: Background: The purpose of this study was to evaluate the influence of smoking history on the clinical-pathological,
sociodemographic and prognostic characteristics of patients with oral squamous cell carcinoma (SCC).
Materials and Methods: A retrospective cohort study was carried out with the records of 136 smokers with SCC and
68 nonsmokers with oral SCC who were diagnosed and treated at Haroldo Juaçaba Hospital (2000-2014). Data on
patient sex, age, race, education level, tumor location, tumor size, lymph node involvement, distant metastasis, treatment
type, marital status, method of health care access (public or private health systems) and overall survival (15 years) were
analyzed by the X² test, Mantel-Cox tests and multinomial and Cox logistic regression models (SPSS 20.0, p <0.05).
Results: Smoking history was directly associated with male sex (p <0.001), low levels of education (p = 0.001), tumors of
the mouth and palate (p = 0.001), stage T3/4 tumors (p = 0.014), lymph node metastasis (N+) (p = 0.024), palliative
treatment (p = 0.024) and receiving health care through the public health system (p = 0.006), with education level
being the only independently associated factor (p = 0.039). Lower survival was observed in patients who were smokers
(p = 0,002), with low levels of education (p = 0.001), who had stage T3/4 tumors (p = 0.004), with N+ (p = 0.021), and
had received palliative treatment (p = 0.002). Age (>65 years old, p = 0.015) and T staging (T3/4, p = 0.033) decreased
the survival of SCC patients regardless of the other factors. Conclusions: Smoking history had an independent association
with low education level and a history of alcoholism, and survival was negatively associated with older age and larger
tumor size, which were more prevalent in smokers.- انتشار مقاله: 30-08-1397
- نویسندگان: Naiara Colares,Deborah Franklin Souza Rodrigues,Milena Oliveira Freitas,Thinali Sousa Dantas,Maria Do Perpétuo Socorro Saldanha Cunha,Fabrício Bitu Sousa,Paulo Goberlânio De Barros Silva
- مشاهده