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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Gastric cancer,Stem Cell,Lgr4,β-catenin
- چکیده:
- چکیده انگلیسی: Background: We evaluated the immunoexpression of LGR4 and β-catenin in primary gastric carcinomas, lymph
node metastases and histologically normal gastric mucosa in the surgical margins of gastric primary tumours. Methods:
We performed a cross-sectional, observational study, based on 75 gastric carcinoma specimens from gastrectomies
conducted at the hospital of the Federal University of Ceará, Brazil. The samples were analysed by tissue microarray and
immunohistochemistry. Chi-square, Fisher’s exact test and Pearson’s linear regression were used in this study. Results:
LGR4 expression was greater in the histologically normal gastric mucosa (basal third of the epithelial thickness) of the
tumour surgical resection margin than in the cases of primary carcinomas (P<0.001, mainly diffuse-histotype cancer
margins), and also in the number of cells stained in the normal mucosa (P<0.0001). Primary intestinal-type carcinomas
showed greater positivity for LGR4 than diffuse tumours (59% vs 13%, P<0.0001) and in these the positivity was
higher in the metastases (P=0.0242). The membranous immunoexpression of β-catenin was ubiquitous in the normal
mucosa and present in 2/3 of the positive carcinomas. In only one case, nuclear β-catenin expression was observed.
Most LGR4-positive cases were stained for membranous β-catenin but not the opposite (P<0.01). Conclusion: LGR4
is a likely biomarker of stem cells in the normal gastric mucosa and carcinomas of the stomach, not specific to cancer
cells and positively associated with cell proliferation. LGR4 immunoexpression is more frequent and found in a larger
number of cells in normal tissues than in tumour samples. Expression of β-catenin in the junctional membrane-complex
occurred predominantly, in positive cases of gastric carcinomas and very rarely in the nucleus. LGR4 apparently
influenced the membranous expression of β-catenin. These findings suggest a controversial role for LGR4, related to
proliferative status and inversely related to tumour progression, in contrast to most previous reports.- انتشار مقاله: 18-03-1397
- نویسندگان: Susana Moreira De Souza,Adriana Estela Flores Valiente,Kélvia Miranda Sá,Camila De Carvalho Juanes,Bruno Jucá Rodrigues,Amanda Cristina Crispim Farias,Caroline Cavalcante Campelo,Paulo Goberlânio De Barros Silva,Paulo Roberto Carvalho De Almeida
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: oral cancer,treatment,head and neck cancer,Health related quality of life,Brazil
- چکیده:
- چکیده انگلیسی:
Background: The purpose of the present study was to compare the preoperative and postoperative health related quality of life (HRQoL) of a sample of patients undergoing primary surgery for oral cancer in 2012-13. Materials and Methods: A cross-sectional, prospective study of 54 patients in a Brazilian population was performed. HRQoL was measured preoperatively (after histopathological diagnosis) and postoperatively (2 months after surgery) using the University of Washington Quality of Life Questionnaire (UW-QOL). Clinicopathological, sociodemographic and lifestyle data were collected. Results: Surgery had a negative impact on most HRQoL domains, but pain, mood and anxiety scores were significantly improved. Most patients rated their health-related and overall postoperative HRQoL as good or very good. Conclusions: The UW-QOL was efficient at measuring HRQoL in our sample of patients with oral cancer. Surgery had a negative impact on HRQoL, especially due to sequelae affecting the stomatognathic system, yet patients classified their postoperative health-related and overall QoL as positive. Qualitative studies are necessary for confirmation of our results and further exploration.- انتشار مقاله: 13-11-1395
- نویسندگان: Thales Salles Angelim Viana,Paulo Goberlânio De Barros Silva,Karuza Maria Alves Pereira,Mario Rogério Lima Mota,Ana Paula Negreiros Nunes Alves,Eric Fernandes De Souza,Fabricio Bitu Sousa
- مشاهده