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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Breast cancer,Metastases,Young Women
- چکیده:
- چکیده انگلیسی:
Background: In Mexico, breast cancer (BCa) is in first place regarding cancer mortality and has been established as a priority health issue. The incidence of metastasis from BCa is very high and presents as the principal mortality factor among women younger than 40 years of age. OBJECTIVE. To determine any associations between clinicopathological characteristics and metastasis in Mexican women under 40 years of age. Methods: During the 2010–2015 period, a total of 180 female BCa cases seen at the Navy General High Specialty Hospital, SEMAR, in Mexico City; we collected information on 20 patients with BCa younger than 40 years of age. Statistical analyses were conducted using the Kolmogorov–Smirnov, Students t, Fisher, Chi square, and Mantel–Haenszel tests. Results: The prevalence of women with BCa younger than the age of 40 years during the 2010–2015 period was 13.3%. We found a high frequency of obesity in of these cases (>75%); 100% of obese patients with a history of smoking presented with metastasis (p <0.05). In addition, the hormone phenotype was important; HER2-positive cases were 12 times more likely tto exhibit metastasis (p <0.05), while expression of estrogen and progesterone receptors appeared to be protective. Diabetes mellitus in combination with smoking was also a risk factor for development of metastasis (p <0.05). Conclusion: In this study, we obtained essential data regarding risk of metastasis in young breast cancer cases which could be useful for predicting disease evolution and treatment response.- انتشار مقاله: 26-07-1395
- نویسندگان: Azucena Moreno Rosales,Miguel Corres Molina,Jacqueline Góngora Moo,Pablo Romero Morelos,Cindy Bandala
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Prognosis,HPV,laryngeal cancer,EGFR
- چکیده:
- چکیده انگلیسی: Introduction: In Head and Neck (HN) cancer, the High-Risk Human Papillomavirus (hr HPV) infection has been
associated in about 40% of these tumors. The hr HPV infection is one of the etiological factors of several epithelial
tumors; however, its association with the prognosis has not yet been established for patients with Laryngeal Squamous
Cell Carcinoma (LSCC). On the other hand, Epidermal Growth Factor Receptor (EGFR) is a molecular marker widely
studied in cancer and its overexpression has been associated with poor prognosis in some types of cancer, including
the HN cancer. In the present study, we analyzed EGFR expression and HPV detection in a cohort of Mexican patients
with LSCC and define their association with clinical-pathological and survival parameters. Methods: EGFR expression
analysis was performed by immunohistochemistry assay. A tissue array was constructed based on 30 paraffin-embedded
tissue samples. HPV detection was performed by PCR. The results were then compared with the clinical-pathological
variables and outcome measures (Kaplan Meier and Cox analysis). Results: High expression of EGFR was observed
in 43% of the samples and 20% of HPV detection. The statistical analyses provided evidence of disassociation between
clinical-pathological parameters and EGFR expression, but there was an association with poor prognosis. Interestingly,
HPV detection is slightly associated with good prognosis. Conclusion: Both, EGFR overexpression and HPV presence
could be associated with an unfavorable prognosis in patients with LSCC, independently of other clinical-pathological
factors.- انتشار مقاله: 25-11-1396
- نویسندگان: Raul Peralta,Paola Garcia,Alejandra Valdivia,Arianna Lopez,Teresa Apresa,Dulce M Hernandez,Francisco Gallegos,Isabel Alvarado-Cabrero,Cruz Vargas-De-León,Sonia Davila,Pablo Romero,Mauricio Salcedo
- مشاهده