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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Trends in Pharmaceutical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: Inpatient,intravenous immunoglobulin,Drug utilization evaluation
- چکیده:
- چکیده انگلیسی: Introduction: The goal of DUE is to improve patients’ care. Studying the administration and utilization pattern of IVIg is an important research topic due to its significant role in the treatment and control of many disorders, high prices, and limited availability. We aimed to evaluate the pattern of IVIg use in an educational hospital.
Material and methods: In this descriptive-cross sectional and retrospective study, 250 patients’ records included medical orders, nursing notes and drug chart were studied. We used FDA and UK protocol to evaluate of IVIg indications in our study. Data were analyzed using SPSS software.
Results: Prescription of IVIg in our hospital adhered to FDA- approved indications and red indications of UK guideline with 64.1% and 67.6%, respectively. ITP was the most common cause of the correct prescriptions (52.7% based on FDA guideline and 50% based on UK guideline). Sepsis (15.5%), hyperbillirubinemia (10.4%), encephalitis (3.5%), and aplastic anemia (1.38%) were incorrect indications of IVIg in our study. ADRs was observed in 14.5% of patients.
Discussions: Consumption of IVIg in our hospital, was more consistent with international guidelines compared with other hospitals in IRAN, of course unnecessary prescriptions cannot be ignored. We suggest to develop own national guideline and educate our prescribers to minimize irrational prescription of expensive and important medicines such as IVIg.- انتشار مقاله: 26-11-1397
- نویسندگان: Motahareh Ahmadi,Omid Safa,Abd Nazemi,Bahram Doorandish,Fahimeh Gharaie Pour,Maryam Montaseri
- مشاهده
- جایگاه : پژوهشی
- مجله: Trends in Pharmaceutical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی:
- چکیده:
- چکیده انگلیسی: AbstractBackground: The incidence of drug interactions in hospitalized patients due to the administration of various drugs, the lack of proper monitoring and sometimes multiple patient’s co-morbidities, is common. This study aims to evaluate potential drug-drug interactions (PDDIs) in pediatrics hospitalized in an educational pediatric hospital. Methods: The present study is a retrospective cross-sectional study. The study population included patients hospitalized in different parts of Bandar Abbas pediatrics hospital. A total of 400 medical records were assessed. PDDIs were evaluated by Lexi-Comp drug interaction and SPSS software was used for data analysis.Result: Based on our results PDDIs were observed in 133 cases (33.25%). The mean ± SD of PDDIs per prescription was 1.97 ± 1.56. The majority of the interaction were moderate (79.1%) with risk rating C (45.7%). Salbutamol, phenytoin, phenobarbital and clarithromycin were responsible for the most interactions with 95, 40, 25,17 of PDDIs, respectively. Drug interactions with risk-rating X, observed in 5 cases. Number of drugs per prescription was significantly associated with PDDIs (P= 0.000)Conclusion: Although the prevalence rate of PDDIs in this study was lower than reported by recent studies, but careful evaluation of drug charts and implantation of educational programs for medical staff, should be considered. Abbreviation PDDIs: Potential Drug-Drug InteractionsDDIs: Drug-Drug InteractionsED: Emergency departmentNICU: Neonatal Intensive Care UnitPICU: Pediatric Intensive Care Unit
- انتشار مقاله: 01-09-1397
- نویسندگان: Motahareh Ahmadi,Abd Nazemi,Seyedeh Fatemeh Davoodpour,Fahimeh Gharaie Pour,Maryam Montaseri,Omid Safa
- مشاهده
- جایگاه : پژوهشی
- مجله: Trends in Pharmaceutical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: Rat,WOUND HEALING,silver sulfadiazine,ALPHA,melilotus officinalis
- چکیده:
- چکیده انگلیسی: Introduction: burn wounds are common happenings which cause many people have irreversible defects and to be death around the world every year. In this study, we evaluated the effects of Melilotus officinalis and Alpha ointment in the healing of burn wounds and compare their findings with silver sulfadiazine (SSD).Methods: Seventy-five male Sprague-Dawley rats were randomly divided into five groups, and similar burn ulcers were produced on the back of rats. The first group of rats received no treatment, base gel was used topically to group II, in groups III-V, Alpha, SSD and Melilotus officinalis preparations were applied, respectively. Wound healing, contraction and histopathological examination were evaluated at the end of 7, 14, and 21 days.Results: Alpha ointment was equally effective as Melilotus officinalis gel, while its efficacy was better compared to SSD for all parameters of wound healing on days 7, 14 and 21. Alpha and Melilotus officinalis preparations as less expensive medications which significantly improve the quality of wound healing and scar formation and also are more appropriate treatment choices than SSD.Conclusion: Alpha and Melilotus officinalis are recommended as alternative to SSD, especially in patients with low economical backgrounds or in those who show adverse reactions to SSD.
- انتشار مقاله: 04-11-1396
- نویسندگان: Nader Tanideh,Omid Safa,Saeedeh Kheradmand,Mohammad Mehdi Zarshenas,Maral Mokhtari,Omid Koohi Hosseinabadi,Anahita Seddighi,Akram Jamshidzadeh,Babak Shirazi Yeganeh,Mahmoud Omidi,Sajad Daneshi
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: Iran,Quality of Life,Adolescent,Child
- چکیده:
- چکیده انگلیسی: Background: Health-related quality of life (HRQoL) has become a major concern in the field of children’s health research. We assessed HRQoL among Iranian children and adolescents according to the socioeconomic status (SES) of their living region.Methods: Via multistage cluster sampling from rural and urban school students aged 6 to 18 years, this nationwide study was conducted from 2011 to 2012. HRQoL was assessed using the adolescent core version of the Pediatric Quality of Life questionnaire. Through survey data analysis methods, the data were compared according to the SES of the living region, sex, and the living area.Results: Overall, 23043 students participated in the survey (participation rate=92.2%). The mean age of the participants was 12.55±3.31 years. Boys accounted for 50.8% of the study population, and 73.4% were from urban areas. At national level, the mean of the HRQoL total score was 81.7 (95% CI: 81.3 to 82.1) with a mean of 83.5 (95% CI: 83.0 to 84.1) for the boys and 79.8 (95% CI: 79.1 to 80.5) for the girls. The highest and the lowest scores, respectively, belonged to social functioning (90.0 [95% CI: 89.7 to 90.3]) and emotional functioning (78.2 [95% CI: 77.7 to 78.7]). The highest total HRQoL score belonged to the second highest SES region of the country (mean=83.1; 95% CI: 82.5 to 83.7). The association between total HRQoL and the score of all the subscales and SES in the living area was statistically significant (P<0.001).Conclusion: The results of the present study showed that in the children and adolescents, SES was associated with HRQoL. Accordingly, HRQoL and the related SES differences should be considered one of the priorities in health research and health policy.
- انتشار مقاله: 13-04-1396
- نویسندگان: Roya Kelishadi,Saeid Safiri,Shirin Djalalinia,Sareh Miranzadeh,Mohammad Esmaeil Motlagh,Hamid Asayesh,Shaghayegh Beshtar,Morteza Mansourian,Armita Mahdavi Gorabi,Omid Safari,Mostafa Qorbani
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Fisheries Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: Hematology,Methionine,lysine,Soy protein,Digestive enzymes activity,Sparidentex hasta
- چکیده:
- چکیده انگلیسی: The effect of dietary partial replacement of fish meal (FM) by soybean protein (SP) alone or in combination with lysine (Lys) and methionine (Met) supplementation were tested in a 60-days feeding trial for silvery-black porgy (Sparidentex hasta) juveniles. Seven isoproteic (ca. 50% crude protein) and isoenergetic (ca. 22.4 MJ/kg) diets were formulated in which 45% (SP45), 60% (SP60) and 75% (SP75) of FM protein were replaced by SP and the control diet (FM) was prepared with FM as the major source of protein. In SP45+, SP60+ and SP75+ diets, 45 to 75% of FM was replaced by SP with supplementing blends of Lys and Met (98% of purity). The activities of the trypsin, lipase and α-amylase were higher in fish fed SP diets with crystalline amino acids supplementation than in the other groups (P < 0.05). Fish fed SP75 and SP75+ diets had the lowest red blood cell count and hematocrit level (P < 0.05). The results of the current study indicated that anti-nutritional factors in a soy-protein based diet rather than lysine and methionine deficiencies may have adverse effects on digestive enzymes activities and health condition in silvery-black porgy juveniles.
- انتشار مقاله: 14-06-1395
- نویسندگان: Morteza Yaghoubi,Mansour Torfi Mozanzadeh,Jasem Ghafle Marammazi,Omid Safari,Enric Gisbert
- مشاهده
- جایگاه : پژوهشی
- مجله: International Journal of Pediatrics
- نوع مقاله: Journal Article
- کلمات کلیدی: anxiety,Infant,Mother,Neonatal Intensive Care Unit,Preterm
- چکیده:
- چکیده انگلیسی: Background: Preterm birth and subsequent admission of the infant to neonatal intensive care unit (NICU) can be distressing for parents and lead to their anxiety. The aim of this study was to evaluate maternal anxiety in mothers of infants admitted to the NICU and determine the characteristics associated with maternal anxiety.
Materials and Methods: This study is a descriptive, cross-sectional study with participation of 100 mothers with infant that was born premature and hospitalized in NICU (mothers were selected through convenient sampling method) of Al-Zahra hospital, affiliated to Tabriz University of Medical Sciences, Tabriz, Iran. Data collection tools included baseline characteristics (21 items), and Spielberger State-Trait Anxiety Inventory (STAI). Data were analyzed using SPSS software (version 23.0).
Results: The results of study showed that 62% (n=100) of mothers had moderate level of state anxiety and (54% (n=100) had moderate level of trait anxiety, mean (SD) state anxiety score was 48.62(6.00) and mean (SD) trait anxiety was 32.45(3.63. There was statistically significant difference regarding state anxiety mean scores and number of delivery, education level, gestational age at birth weeks and child order (P<0.05).
Conclusion: Based on the results, mother of premature infants had moderate level of state anxiety. Having university degree, the mothers whose premature infants were at 33 weeks gestational age and mothers who had third or more delivery number and their child order was third and over had experienced state anxiety.- انتشار مقاله: 20-03-1398
- نویسندگان: Zhilla Heydarpoor Damanabad,Leila Valizadeh,Mohamadreza Mansouri Arani,Mohammadbager Hosseini,Mohammad Asgari Jafarabadi,Morteza Mansourian,Arash Ziapour,Omid Safari,Amin Mirzaei,Babk Rastegarimehr
- مشاهده
- جایگاه : پژوهشی
- مجله: International Journal of Pediatrics
- نوع مقاله: Journal Article
- کلمات کلیدی: Iran,Public health,Leishmaniasis,Child,cutaneous
- چکیده:
- چکیده انگلیسی: Background: Cutaneous leishmaniasis (CL) is a main public health problem in Iran with a high incidence rate among children. According to numerous studies in Iranian society, the most commonly affected age group is 1–4 years. At present, we aimed to investigate the pediatric CL among children in Golestan Province in North of Iran.
Materials and Methods: A cross-sectional study was run on data existed for 3,371 cases with pediatric cutaneous leishmaniasis based on routinely collected data from the Health System of Golestan Province, Iran, between 2010 and 2017. Data of the study were gathered using two checklists about CL and demographic status from District Health Network. Data were analyzed using SPSS software (version 18.0).
Results: In general, 3371cases were investigated. The majority of cases were male 1495 (50.9%), lived in the rural area, while the least CL were female 155 (38.7 %), and lived in the urban area. Pediatric cutaneous leishmaniasis had the highest 883 (26.3%), and lowest 186 (5.5%) frequency in 2010 and 2013 years, accordingly. CL was increased from July and reached to maximum in October, then decreased considerably in January. In final, a significant relationship was found between CL cases and years of the survey (p= 0.001).
Conclusion: The most CL cases were found among males and aged 0-5 years. As indicated by different studies, CL in the endemic area of the country (Golestan Province) occurs more often in children, while it commonly happens among adolescents in the central area of the country. Thus, it points to the role of mothers in protecting children through dressing up and sleeping habits in the outdoor environments.- انتشار مقاله: 02-02-1398
- نویسندگان: Oghlniaz Jorjani,Hamid Reza Kamalinia,Zahra Mehrbakhsh,Hajar Ziaei-Hezarjaribi,Kumars Pourrostami,Morteza Mansourian,Omid Safari,Mohammad Sadegh Abedzadeh Zavareh,Kamal Mirkarimi
- مشاهده
- جایگاه : پژوهشی
- مجله: International Journal of Pediatrics
- نوع مقاله: Journal Article
- کلمات کلیدی: children,Iran,Clinical manifestations,Brucellosis
- چکیده:
- چکیده انگلیسی: Background
Brucellosis is a zoonotic disease that is widely distributed throughout the developing countries. Children are considered as at risk groups for infection. The aim of this study was to assess the frequency and clinical manifestations of Brucellosis in Iranian children and adolescents.
Materials and Methods: We systematically searched international databases; ISI, Medline (via PubMed), Scopus, and national databases Irandoc, Barakat knowledge network system, Magiran, and Scientific Information Database (SID). The search strategy was developed based on main terms of "Brucellosis," "Brucella fever", "Gibraltar", "Rock Fever", "Undulant Fever", "Cyprus Fever", "Malta Fever", and "Bang Disease".
Results: A total of 885 studies were identified, from them a total of 12 studies that were conducted between 2001 and 2016 were included. Following the relevancy assessments and quality control, data from the 1,429 participants were presented in our review. The age of the patients ranged from 2 to 18 years. Only one out of twelve studies provided the prevalence of 4.30% and 3.4 incidence. Studies varied greatly in reporting high risk behavior of animal contact (8.4 to76.0%) and unpasteurized dairy (22.4 to 91.6%).
Conclusion
Our finding reveals the disparity of reported prevalence and clinical manifestations of Brucellosis in Iranian children. Fever and joint pain were the most frequent reported signs. Differences in study design, measurement tools and methods, and sub population sampling, does not provide the possibility of aggregation of data for more comprehensive inference.- انتشار مقاله: 13-04-1397
- نویسندگان: Shirin Djalalinia,Reza Arjmand,Mehri Gholami,Yasaman Shaker,Sahar Saeedi Moghaddam,Kumars Pourrostami,Omid Safari,Nasrin Elahimehr,Saeed Nik Khah,Ehsan Zahmatkesh,Esfandiar Najafi Tavana,Mostafa Qorbani
- مشاهده
- جایگاه : پژوهشی
- مجله: International Journal of Pediatrics
- نوع مقاله: Journal Article
- کلمات کلیدی: children,Diarrhea,Length of hospitalization,Gastro-Fix Gastroenteritis
- چکیده:
- چکیده انگلیسی: Background: According to evidence, the main treatment plans for children with gastroenteritis include the use of an oral solution or intravenous infusion for hydration, continued nutrition; zinc supplementation. The aim of this study was to investigate the effectiveness of Gastro-Fix (registered nutritional supplement) versus placebo on length of hospitalization and duration of diarrhea in children with acute gastroenteritis.
Materials and Methods: We conducted a double blind randomized placebo-controlled trial in children with acute gastroenteritis (age between 6 and 120 months). Three hundred eligible patients randomly allocated to one of two parallel groups, Intervention received Gastro-Fix, whereas the placebo group received baby food (cereal based on skimmed milk and wheat without mineral) for a total of 6 days. Gastro-Fix and baby food was administered as a same sachet that could be opened and mixed in water. The primary outcome was length of hospitalization and duration of diarrhea.
Results: The Mean length of hospitalization in Gastro-Fix and placebo was 3.43+ 0.57 and 4.70+0.59 day respectively (P<0.001). Median duration of diarrhea was 3 days (range: 3-5, IQR: 3–4 days) in the Gastro-Fix group and 5 days (range 3-6, interquartile range [IQR]: 4–5 days) in the placebo group which was statistically significant (P<0.001). The highest efficacy (diarrhea-free percentage of children) of the Gastro-Fix was observed at day 4 (relative risk [RR]: 0.28; 95% confidence interval [CI]: 0.23-0.35), and at day 5 (RR 0.08; 95% CI: 0.03-0.17) after the intervention.
Conclusion: Finding of this study showed that Gastro-Fix can be effective in reducing duration of diarrhea and length of hospitalization in children with diarrhea. This product is suggested to be used in children with acute gastroenteritis.- انتشار مقاله: 27-10-1396
- نویسندگان: Kumars Porrostami,Reza Arjmand,Hamid Asayesh,Mehdi Noroozi,Omid Safari,Mostafa Qorbani
- مشاهده
- جایگاه : پژوهشی
- مجله: International Journal of Pediatrics
- نوع مقاله: Journal Article
- کلمات کلیدی: Iran,Students,Education,Health Belief Model,HIV/AIDS
- چکیده:
- چکیده انگلیسی: Background: Considering the importance of learning health knowledge and the need to promote appropriate health attitudes, beliefs and behaviors regarding Human immunodeficiency virus infection and acquired immune deficiency syndrome (HIV/AIDS) among school-age people, the aim of this study was to investigate the effect of an educational program based on Health Belief Model (HBM) about HIV/AIDS.
Materials and Methods: This quasi-experimental study was performed on 100 male high school students in Fasa, Iran. A sample size of 100 was determined based on the examination of similar literature with 95% confidence interval and 80% test capability. The subjects were divided into two groups of 50 subjects. After administering a pre-test to both groups, only the experimental group was trained based on the HBM constructs on the HIV/AIDS preventive behaviors. Then intervention was followed by group discussion (10-person groups) in 8 sessions each 55-60 minutes. In order to collect information based on Health Belief Model, a questionnaire consisting of 41 questions in three sections was used. Data were analyzed using SPSS version 22.0 software.
Results: Educational intervention based on Health Belief Model resulted in meaningful enhancement of the subjects’ knowledge, perceived susceptibility, perceived severity, perceived benefits, and perceived self-efficacy (P <0.05). Furthermore, the students’ perceived barriers about beliefs related to HIV/AIDS preventive behaviors decreased significantly (P <0.05).
Conclusion: According to the results, educational intervention has increased the HIV/AIDS prevention behavior based on Health Belief Model. Therefore, the results of this study can be used in the theory-based intervention strategies to create and modify health behaviors.- انتشار مقاله: 06-08-1396
- نویسندگان: Ali Khani Jeihooni,Shideh Arameshfard,Mahmood Hatami,Morteza Mansourian,Seyyed Hannan Kashfi,Babak Rastegarimehr,Omid Safari,Mehdi Amirkhani
- مشاهده