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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Colorectal cancer,Dietary Inflammatory Index,Case-control
- چکیده:
- چکیده انگلیسی: Background: In Iran, colorectal cancer (CRC) is the third and fourth leading cause of cancer incidence among men
and women, respectively. Diet and inflammation have been suggested as important risk factors for CRC. We examined
the association between dietary inflammatory index (DII) scores and CRC in a case-control study conducted in Iran.
Methods: This study included 71 CRC cases and 142 controls hospitalized for acute non-neoplastic diseases. DII
scores were computed from dietary intake assessed by a previously validated food frequency questionnaire. Logistic
regression models were used to estimate odds ratios (ORs) and 95% confidence intervals (CI) adjusted for age, sex,
education, energy intake, exercise, body mass index (BMI), smoking, family history of cancer, and history of aspirin,
acetaminophen, and multivitamin use. Results: Subjects with higher DII scores (i.e., indicating a more pro-inflammatory
diet) had a higher odds of CRC with the DII being used as both a continuous variable (OR continuous = 2.20, 95% CI:
1.22-3.87) and as a categorical variable (OR tertile 3 vs tertile1 = 2.47, 95%CI: 1.10-5.55). Conclusion: These results
indicate that a pro-inflammatory diet is associated with increased odds of CRC in this Iranian population.- انتشار مقاله: 28-12-1396
- نویسندگان: Nitin Shivappa,James R Hebert,Susan E Steck,Akram Safari,Fatemeh Sedaghat,Bahram Rashidkhani
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Inflammation,Gastric cancer,Dietary Inflammatory Index (DII),Inflammatory Factors,Validation of DII
- چکیده:
- چکیده انگلیسی: Background: Gastric cancer (GC) is the fifth most common malignancy and the second leading cause of cancerrelated
deaths worldwide. Studies have shown that dietary components and inflammation are implicated in the etiology
of GC. Methods: We examined the ability of a dietary inflammatory index (DII) to predict the odds of GC in a casecontrol
study conducted from December 2014 to May 2016. The subjects were 82 cases and 95 controls who attended
specialized centers in Tabriz, Iran. DII scores were computed from a validated 168-item food frequency questionnaire.
Logistic regression models were used to estimate odds ratios (ORs) adjusted for age, sex, body mass index, education,
smoking, alcohol, H.pylori infection, physical activity, aspirin/NSAID use and total caloric intake. Results: In the fully
adjusted model, subjects with a DII score >-1.77 had nearly 3.5 times higher odds of having GC compared with subjects
with DII≤-1.77, (ORDII>-1.77≤-1.77=3.39; 95%CI=1.59, 7.22). Also, for every one-unit increase in DII, there was a
corresponding increase in hs-C-reactive protein, tumor necrosis factor-alpha, interleukin (IL)-6 and IL-1b: β=0.09, 0.16,
0.16 and 0.10, respectively; and a corresponding decrease in IL-10: β=-0.11. Conclusion: Subjects who consumed a more
pro-inflammatory diet were at increased odds of GC compared to those who consumed a more anti-inflammatory diet.- انتشار مقاله: 13-03-1396
- نویسندگان: Farhad Vahid,Nitin Shivappa,Zeinab Faghfoori,Adeleh Khodabakhshi,Farid Zayeri,James R Hebert,Sayed Hossein Davoodi
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Breast cancer,Inflammation,Dietary Inflammatory Index (DII),Nutritional Assessment
- چکیده:
- چکیده انگلیسی: Background: Breast cancer (BrCa) is the most common cancer among women worldwide and is the second
leading cause of cancer-related death in women, in developed countries. This cancer is among the top five most
common cancers in Iran. Studies have shown that dietary components are implicated in the etiology of BrCa. The
existence of molecular connections between inflammation and BrCa has been demonstrated via different bimolecular
events. Methods: We examined the ability of the dietary inflammatory index (DIITM) to predict the risk of BrCa.
This included 145 cases and 148 controls, who attended the specialized centers. DII scores were computed based
on dietary intake assessed using a 168-item FFQ. Logistic regression models were used to estimate multivariable
ORs. Results: Modeling DII as a continuous variable in relation to risk of BrCa showed a positive association after
adjustment for age and energy (OR=1.76; 95% CI=1.43-2.18); and were nearly identical in the multivariable analyses
(OR=1.80; 95% CI=1.42-2.28). DII as tertiles, and adjusting for age and energy, subjects in tertile 3 had an OR of 6.94
(95% CI= 3.26-14.79; P-trend ≤0.0001) in comparison to subjects in tertile 1. After multivariable adjustment, results
were essentially identical as in the model adjusting for age and energy (OR tertile 3vs1=7.24; 95% CI=3.14-16.68;
P-trend ≤0.001). Sub group analyses revealed similar positive associations with HER 2 receptor +ve, progesterone
receptor +ve, estrogen receptor +ve and lymph node invasive cases. Conclusion: Subjects who consumed a more
pro-inflammatory diet were at increased risk of BrCa compared to those who consumed a more anti-inflammatory diet.- انتشار مقاله: 26-02-1396
- نویسندگان: Farhad Vahid,Nitin Shivappa,Mahshid Hatami,Mahya Sadeghi,Fatemeh Ameri,Yasaman Jamshidi-Naeini,James R Hebert,Sayed Hossein Davoodi
- مشاهده