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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Journal of Dentistry, Shiraz University of Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: Pathogenesis,Oral lichen planus,B Cell,plasma cell
- چکیده:
- چکیده انگلیسی: Statement of the Problem: Oral lichen planus (OLP) is a chronic inflammatory disease with unknown etiopathogenesis. It was believed that T cells played the major role in developing the lesions. It has been recently suggested that B cells and plasma cells may play a role in OLP pathogenesis.
Purpose: OLP is considered as a T-cell mediated disease. It was believed that the presence of B-cells and plasma cells in the sub-epithelial inflammatory infiltrate, rules out the diagnosis of OLP. This study aims to investigate the presence of B lymphocyte and plasma cells in the inflammatory infiltrate of OLP. Also the association between the presence of B cells and plasma cells with histopathologic features of the lesion was assessed.
Materials and Method: To assess the presence of B cells and plasma cells, 61 cases with the diagnosis of OLP were collected. The cases with definite clinical and histopathological diagnosis of lichen planus based on WHO criteria were included. For each case demographic information and histological characteristics were recorded. Specimens underwent immunohistochemical (IHC) staining for CD20 and CD138 and the percentage of the positive cells were counted and scored.
Results: CD20 positive cells existed in all OLP cases with the mean expression of 22.5% ± 15.17% and small number of CD138 positive cells were seen in 62.3% of our cases with the mean expression of 4.74% ± 9.23%. No association was found between histolopathological features and CD138 expression, however, CD20 expression level was higher in the cases with parakeratinized surface (p = 0.004).
Conclusion: B cells existed in the inflammatory infiltrate of OLP in all cases. Small number of plasma cells could be occasionally found in OLP. Therefore, presence of B cells and plasma cells in the inflammatory infiltrate cannot rule out the diagnosis of OLP.- انتشار مقاله: 21-02-1398
- نویسندگان: Nazanin Mahdavi,Pouyan Aminishakib,Nika Soltani
- مشاهده
- جایگاه : پژوهشی
- مجله: Journal of Dentistry, Shiraz University of Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: odontogenic tumor,Calcifying Odontogenic Cyst,Ameloblastic fibroma
- چکیده:
- چکیده انگلیسی: Calcifying odontogenic cyst (COC) is an uncommon odontogenic lesion that represents less than 2% of all odontogenic cysts and tumors. It usually occurs in incisor and canine areas during the second to fourth decades of life. It can be associated with other lesions like odontoma, Ameloblastic Fibroma, Ameloblastoma, Adenomatoid odontogenic tumors, Odontoameloblastoma, and Odontogenic Myxoma. Ameloblastic fibroma is a truly mixed tumor usually diagnosed within the posterior mandible during the first two decades of life. In the present article, a hybrid odontogenic tumor composed of COC and Ameloblastic Fibroma in a 14-year-old white Persian female is described.
- انتشار مقاله: 01-06-1397
- نویسندگان: Nazanin Mahdavi,Neda Kardooni Khoozestani,Mahboube Hasheminasab,Nika Soltani
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Breast cancer,Bioinformatics,Glutathione S-Transferase,Genetic polymorphism
- چکیده:
- چکیده انگلیسی:
Background: Polymorphisms in glutathione S-transferase (GST) genes may contribute to breast cancer risk. The aim of this study was to investigate any association of two common GSTO1 A140D and GSTO2 N142D gene polymorphisms with breast cancer risk in an Iranian population followed by a protein structure analysis. Materials and Methods: In the case-control study, 303 subjects comprising 153 women with breast cancer and 150 healthy controls were included. Genotypes of GSTO1 A140D and GSTO2 N142D polymorphisms were assessed by PCR-RFLP. Bioinformatics tools were employed to evaluate the damaging effects of A140D and N142D on the structures of GSTO1 and GSTO2 proteins. Results: Our genetic association study revealed that the GSTO1 A140D polymorphism was associated with breast cancer in a dominant model (OR= 1.75, 95%CI= 1.07-2.86, p= 0.026). Also, the A allele was significantly associated with breast cancer risk (OR= 1.69, 95%CI= 1.09-2.60, p= 0.018). With regard to the N142D polymorphism, there were significant associations between the GG genotype (OR= 2.20, 95%CI= 1.14-4.27, p= 0.019) and the G allele (OR= 1.47, 95%CI= 1.06-2.05, p= 0.021) and risk of breast cancer. Structural analysis revealed that A140D and N142D polymorphisms cause changes in both primary and secondary structures of GSTO1 and GSTO2, respectively. Conclusion: Based on our results, GSTO1 A140D and GSTO2 N142D polymorphisms could be genetic risk factors for breast cancer, but further studies with larger sample sizes focusing on different ethnicities are needed to obtain more comprehensive results.- انتشار مقاله: 24-02-1396
- نویسندگان: Mohammad Reza Sharif,Alireza Sharif,Davood Kheirkhah,Mahsa Taghavi-Ardakan,Nika Soltani
- مشاهده