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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Trends in Pharmaceutical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: Rat,Liver,Mitigation,toxicity,Resveratrol,5-Fluoroural
- چکیده:
- چکیده انگلیسی: The manifestation of acute hepatotoxicity caused by 5-fluorouracil could be characterized by asymptomatic elevations of liver enzymes, hepatic steatosis and fuminant hepatitis. Natural antioxidants have potential as excellent treatment strategy against diseases and drug-induced toxicities. This study assessed the potential of resveratrol (RSV) to abrogate the hepatotoxic effect of 5-FU in rats. Forty adult male albino rats (240g± 20g) were randomized and orally supplemented with RSV (10, 20 and 40 mg/kg/day) prior to the administration of 5-FU (20mg/kg/day) intraperitoneally for 5 days. On day 6, after weighing, the rats were anesthetized, blood samples were collected and centrifuged and sera obtianed. Liver tissues were harvested and weighed. Sera and liver samples were evaluated for biochemical parameters. Liver tissues were assessed for histology. Body weight was significantly (p <0.05) decreased where as liver weight was significantly (p <0.01) increased in 5-FU administered rats in relation to control. Serum and liver lactate dehydrogenase, aminotransferases (AST), alkaline phosphatase, gamma-glutamyl transferase, total bilirubin, conjugated bilirubin and malondialdehyde levels were significantly (p <0.001) increased in 5FU-administered rats in relation to control. Liver glutathione peroxidase, catalase, glutathione and superoxide dismutase levels were significantly (p <0.001) decreased in 5-FU administered rats in relation to control. The liver of 5-FU administered rats showed necrosis and steatosis. The hepatotoxic effect of 5-FU was abrogated in a dose-related fashion in RSV 10 mg/kg (p <0.05), 20mg/kg (p <0.01), and RSV 40mg/kg (p <0.001) supplemented rats in relation to 5-FU. RVS may be clinically effective against 5-FU-induced hepatotoxicity.
- انتشار مقاله: 01-06-1399
- نویسندگان: Elias Adikwu,Nelson Ebinyo,Clara Ejovwoke Clara Adogbo Ejovwoke
- مشاهده
- جایگاه : پژوهشی
- مجله: Advanced Herbal Medicine
- نوع مقاله: Journal Article
- کلمات کلیدی: Antidepressant,Zea mays,CNS stimulant
- چکیده:
- چکیده انگلیسی: Background and aims: Zea mays L. (Poaceae) husk extract is used traditionally in Ibibio traditional medicine for the treatment of various diseases such as malaria, pains, inflammatory diseases and central nervous system disorders.
Methods: The husk extract (187-748 mg/kg) was evaluated for antidepressant activity in mice using open field, force swimming and tail suspension tests. Determination of median lethal dose (LD50) and phytochemical screening of the husk extract were also carried out using standard methods.
Results: The husk extract increased significantly the line crossing, walling and rearing activities of mice in open field test (P<0.05-0.001) and reduced significantly the immobility time in force swimming test (P<0.05-0.001). However, the immobility time in tail suspension tests was significantly increased by the extract (P<0.05-0.001).
Conclusion: The husk extract of Z. mays has prominent antidepressant activity which is due to the activities of its phytochemical constituents such as phenolic compounds.- انتشار مقاله: 06-09-1395
- نویسندگان: JUDE EFIOM OKOKON,Nelson Ebinyo,Michael Sunday
- مشاهده