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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Cholangiocarcinoma,Survival,hepatectomy,Liver failure,Bilirubin
- چکیده:
- چکیده انگلیسی: Objective: All types of cholangiocarcinoma (CCA) require a major hepatectomy, which has many post-operative complications. All complications usually present with persistent hyperbilirubinemia; however, studies on the prediction of post-operative hyperbilirubinemia after hepatectomy for patients with CCA are lacking. We evaluated the causes and patterns of persistent hyperbilirubinemia among the patients who underwent hepatectomy for CCA. Methods: We retrospectively reviewed the records of 216 CCA patients who underwent curative-intent hepatic resection between January 2015 and December 2016. We identified five patterns of hyperbilirubinemia for predicting the cause of persistent hyperbilirubinemia and the respective patient outcome. All clinical parameters and outcomes were analyzed for any significant associations. Results: Twenty-eight patients (24%) had post-operative persistent hyperbilirubinemia. Of these, liver failure was the most common cause (42.9%), followed by bile leakage (14.3%), then cholangitis (3.6%). Re-rising of the bilirubin level after post-operative day 3(the ‘V’ pattern), very well predicted liver failure. Moreover, this pattern was associated with poor survival of the patient. Conclusion: The current study provided a picture of persistent hyperbilirubinemia after hepatectomy for CCA. The proportion of post-operative liver failure was 12 percent. The pattern of serum bilirubin level could be used as a predictor of liver failure and long-term outcomes of CCA patients. The ‘V’ pattern was significantly associated with a high rate of liver failure and poor survival.
- انتشار مقاله: 30-04-1399
- نویسندگان: Weerin Sawangkajohn,Vor Luvria,Natwutpong Leeratanakachorn,Theerawee Tipwaratorn,Suapa Theerakul,Apiwat Jarearnrat,Attapol Titapun,Tharatip Srisuk,Ake Pugkhem,Narong Khuntikeo,Vajarabhongsa Bhudhisawasdi,Supot Kamsa-ard
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Liver Fluke,Cyprinoids fish,Opisthorchis viverini,heating,Fermentation
- چکیده:
- چکیده انگلیسی:
Consumption of fluke-free fish is the most important factor in controlling Opisthorchis viverrini (OV) infection in endemic areas such as northeast Thailand and thereby reducing the risk of cholangiocarcinoma. Cooking fish is the best way to avoid infection; however, the cultural practice of eating raw or fermented fish is difficult to change. We investigated the food preparation process, using freezing, heating and fermentation to kill OV metacercariae in fish. Uncooked cyprinid fish infected with OV were divided into three groups: refrigerated at 4 oC for 24, 48 or 72 h (control group); frozen at -20 oC for 24, 48 or 72 h; or heated by microwaving (at 400 or 800 W) or boiling at 90 oC for 1, 5 or 10 min. Moreover, pickled (fermented) fish were divided into two groups: refrigerated at 4 oC (control) or frozen at -20 oC for 24 or 48 h. The infectivity of recovered metacercariae was confirmed by infecting hamsters with OV and then evaluating the recovery of adult worms after 1 month. We found that a heating process, by boiling or microwaving at 400 or 800 W for at least 5 min, could kill OV metacercariae, and freezing pickled fish at -20 oC for 48 h could kill OV metacercariae in all sizes of fish. The present study found that heating and freezing processes, as well as the fermentation process under optimal conditions, could kill OV metacercariae in a timely manner. This knowledge is valuable for implementation in endemic areas to control OV infection and cholangiocarcinoma.- انتشار مقاله: 09-11-1395
- نویسندگان: Panupan Sripan,Thidarut Boonmars,Jiraporn Songsri,Ratchadawan Aukkanimart,Pranee Sriraj,Panaratana Ratanasuwan,Parichart Boueroy,Apiporn Suwannatrai,Surasit Aunpromma,Narong Khuntikeo,Watcharin Loilome,Nisana Namwat,Puangrat Yongvanit,Aung Phyo Wai,Sukhonthip Khueangchaingkhwang,Wu Zhiliang,Benjamabhorn Pumhirunroj,Atchara Artchayasawat,Sirintip Boonjaraspinyo
- مشاهده