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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Breast cancer,HER2,Reproductive,Tumor marker,tumor molecular subtypes
- چکیده:
- چکیده انگلیسی: Background: Due to wide clinical differences in the various pathological types of breast cancer and also close
associations between disease prognosis and molecular subtypes, relationships of the latter with traditional risk factors
have been suggested. Hence, the present study aimed to assess any associations. Methods: This bi-center cross-sectional
study was performed on 800 consecutive women with known breast cancer referred to two Comprehensive Cancer Centers
in Tehran between 2006 and 2016. Baseline information related to reproductive risk profiles as well as pathological
tumor diagnosis and molecular subtypes determined using immunohistochemical analysis by immune-staining for
ER, PR, and HER2 molecules were collected by reviewing hospital records. Results: Of 800 samples included for
immunohistochemical analysis, 314 (39.3%) were diagnosed as of Luminal A subtype, 107 (13.4%) as Luminal B
subtype, 153 (19.1%) as HER-2 over-expressing, and 226 (28.3%) as triple negative. Among all reproductive risk
factors initially assessed, young age was associated with HER-2 over-expression, greater tumor size and a history of
abortion with the luminal B subtype, lower age at pregnancy with the luminal A subtype, and lower gravidity and
a shorter duration of breastfeeding with the triple negative subtype. Conclusion: Each molecular subtype of breast
cancer in our population may be associated with specific reproductive risk factors.- انتشار مقاله: 07-02-1396
- نویسندگان: Nahid Nafissi,Maryam Faraji,Mostafa Hosseini,Leyla Shojaee,Fatane Ziaee,Mohamad Esmaiel Akbari,Seyed Hamzeh Mousavie
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Prognosis,Survival,Recurrent breast cancer
- چکیده:
- چکیده انگلیسی: Background: Recurrence of breast cancer after treatment is generally due to loco-regional invasion or distant
metastasis. Although patients with metastasis are considered incurable, existing treatments might prolong a patient’s life
while also improving its quality. Choice of approach for individual patients requires identification of relevant survival
factors. This study concerns factors influencing survival after recurrence in Iranian breast cancer patients. Methods: This
study was performed on 442 recurrent breast cancer patients referred to the Cancer Research Center of Shahid Beheshti
University between 1985 and 2015. After confirming recurrence as a distant metastasis or loco-regional invasion, the
effects of demographic, clinic-pathologic, biological, type of surgery and type of adjuvant treatment on survival were
evaluated using univariate and multivariate stratified Cox models. Results: The mean survival after recurrence was
18 months (5 days to 13 years), 219 patients (70.42%) survived two years, 75 patients (24.12%) survived from 2 to 5
years, and 17 patients (5.47%) survived more than 5 years. In this study, it was found through univariate analysis that the
factors of age, lymph node status, DFI, place of recurrence and nodal ratio demonstrated greatest influence on survival
after recurrence. On multivariate analysis, the most important factors influencing survival were the place of recurrence
and the lymph node status. Conclusion: The results of this study enhance our knowledge of effects of different factors
on survival of patients after breast cancer recurrence. Thus, they may be used to inform treatment choice.- انتشار مقاله: 16-06-1396
- نویسندگان: Mohammad Esmail Akbari,Marzieh Rohani- Rasaf,Nahid Nafissi,Atieh Akbari,Leyla Shojaee
- مشاهده