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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: International Journal of Pediatrics
- نوع مقاله: Journal Article
- کلمات کلیدی: children,Malnutrition,Cystic fibrosis,Nutrition Assessment
- چکیده:
- چکیده انگلیسی: Background: Malnutrition is one of the most common disorders among children with Cystic Fibrosis (CF). The present study aimed to investigate the effect of nutritional consultation on the type and severity of malnutrition in children with CF.
Materials and Methods: This quasi-experimental study was conducted on 78 children with CF referred to Mofid Pediatric Hospital, Tehran, Iran, in 2017-2018. Their parents filled the demographic questionnaire. Participants with malnutrition were undergoing the assessment on growth indices, including weight, height, ideal body weight, mid-upper arm circumference, and Z-score. Moreover, the nutritional consultations were considered for them (30-45 minutes). Children and their parents were consulted and trained about total daily calorie acquirement, type, number of the meal, amount of food intake, drinks, and avoided eating of any low-calorie food like snacks, during the consultation. All patients were reassessed three months later for growth indices. The data were analyzed using SPSS software version 22.0.
Results: We assessed 78 children with CF, 21 (26%) of them had mild, 26 (34%) moderate malnutrition, and 31 (40%) severe malnutrition. The result showed that nutritional intervention was effective. Consequently, 1 (3.8%) of the moderately malnourished child was improved to mild malnutrition and 5 (27.8%) children under five years old were improved from severe to moderate malnutrition. Moreover, 1 (5.6%) child were improved from severe to mild, and 2 (15.4%) of children over five years old were improved from severe to moderate malnutrition.
Conclusion: According to the results, the early growth assessment in hospitalized and outpatient, diagnosis of malnutrition and nutritional interventionwill be useful in improving the severity of malnutrition and growth indices in children with CF.- انتشار مقاله: 22-08-1398
- نویسندگان: Naghi Dara,Farid Imanzadeh,Seyed Ramin Madani,Saleheh Tajalli,Pejman Rohani,Amirhossein Hosseini,Parastoo Ashtigoo,Sayeh Hatefi,Zahra Fazeli Farsani,Mahmoud Hajipour,Katayoun Khatami,Ali Akbar Sayyari,Beheshteh Olang
- مشاهده
- جایگاه : پژوهشی
- مجله: International Journal of Pediatrics
- نوع مقاله: Journal Article
- کلمات کلیدی: children,Antibiotic resistance,Infection,Helicobacter pylori
- چکیده:
- چکیده انگلیسی: Helicobacter Pylori (H. pylori) as a gram-negative bacterium is the most common infection of the gastrointestinal tract, and worldwide it affects the children over three years of age. H. pylori could cause gastrointestinal and extra-intestinal manifestations. Antibiotic resistance can happen primarily and occurs during treatment. We aimed to evaluate the resistance gene of H. pylori obtained from gastric biopsy by polymerase chain reaction (PCR) method in Iranian children over 3 years old.
Materials and Methods
This study was a cross-sectional to evaluate the resistance gene of H. pylori obtained from gastric biopsy by polymerase chain reaction method for metronidazole and clarithromycin in children over three years old referring to the Mofid Children's Medical Center in Tehran, Iran.
Results: Finally, data from seventy-nine samples included (mean age=10.7 years and male gender = 60.8%). Beta Globulin (BG) gene were detectable in 75 (94.93%) specimens of 79 (100%). Seventeen out of 75 specimens showed positive results for molecular detection of H. pylori. The results of RFLP-PCR technique showed that mutation of RdxA gene in seven of 17 (41.1%) for Metronidazole resistance and one case of 17 (5.8%) mutation of 23Y RNA gene that leads to clarithromycin resistance.
Conclusion:
Regarding the results of our study, it is better to check microbial resistance by culture and antibiogram for the antibiotic regimen of the first and second line of H. pylori treatment in children.- انتشار مقاله: 29-05-1397
- نویسندگان: Mohammad Bagher Haghighi,Naghi Dara,Roxana Mansour Ghanaie,Leila Azimi,Amirhossein Hosseini,Saleheh Tajalli,Mahmoud Hajipour,Aliakbar Sayyari,Farid Imanzadeh,Katayoun Khatami,Pejman Rohani,Beheshteh Olang
- مشاهده
- جایگاه : پژوهشی
- مجله: International Journal of Pediatrics
- نوع مقاله: Journal Article
- کلمات کلیدی: children,Inflammatory bowel disease,Chromatography,Serum amino acids
- چکیده:
- چکیده انگلیسی: Background: Given the important role of amino acids in regulating many metabolic pathways of the body and considering the scarcity of markers for the diagnosis of inflammatory bowel disease (IBD) and its differentiation, we aimed to investigate the status of serum amino acids chromatography in children with IBD.
Materials and Methods
This case-control study was conducted among children with primary diagnosis of IBD who referred to Mofid Children's hospital in Tehran, Iran. Children with a definite diagnosis of chronic IBD on the basis of endoscopy and biopsy were enrolled. In addition, 100 children without any history of predisposing, chronic, or inflammatory disease who referred to the same hospital during the period of the study were also selected. All samples underwent serum amino acids chromatography via HPLC method.
Results
Of all the patients in the IBD group, 18 patients (18%) suffered from Crohn's disease and 82 patients (82%) had ulcerative colitis; the disease was active in 54 patients (54%). The results of serum amino acids chromatography showed that several amino acids were significantly higher in patients with IBD. Considering the normal serum levels of amino acids, only the levels of two amino acids of histidine and tryptophan were significantly different in the IBD group compared the control group. In total, of all the subjects, 30 children (15%) had abnormal amino acid serum chromatography; hence, its prevalence was significantly higher in the IBD group (P=0.048).
Conclusion
The current study showed that serum amino acid chromatography in children with IBD were different from that in healthy children. More specifically, the decrease in tryptophan level was more observed in patients with active disease.
- انتشار مقاله: 06-05-1397
- نویسندگان: Farid Imanzadeh,Batool Emadi,Pejman Rohani,Amirhossein Hosseini,Katayoun Khatami,Naghi Dara,Beheshteh Olang,Aliakbar Sayyari
- مشاهده
- جایگاه : پژوهشی
- مجله: International Journal of Pediatrics
- نوع مقاله: Journal Article
- کلمات کلیدی: children,Autoimmune hepatitis,Atypical presentation,Coexistence,Wilson disease
- چکیده:
- چکیده انگلیسی: Background: Wilson's disease (WD) is a genetic disorder with various clinical presentations due to excessive accumulation of copper in the liver and other organs. It can present as acute/chronic hepatitis, liver failure, extrahepatic and neuromuscular manifestations. Autoimmune hepatitis (AIH) is a necroinflammatory disease of the liver, which affects a lot of people particularly the children population. AIH has a broad clinical presentation that is similar to WD. Coexistence of WD with elevated creatinine phosphokinase (CPK) and AIH, may be a diagnostic dilemma.
Case Report: We presented a 6 years old boy with dysarthria, aggressive behavior, weak attention, concentration and weight loss with abnormal physical examination. Laboratory, histochemical, genomic studies, muscle/liver biopsy and atomic absorption test confirmed the diagnosis of both WD and AIH in the boy.
Conclusion
Although CPK and liver enzyme elevation is a rare presentation of chronic hepatitis with dominant feature of WD and AIH; however, simultaneous therapy with immunosuppressive drugs and Penicillamine may have superior benefit with a significant response.- انتشار مقاله: 16-04-1397
- نویسندگان: Naghi Dara,Amirhossein Hosseni,Saleheh Tajalli,Mohammad Amin Shahrbaf,Ali Akbar Sayyari,Farid Imanzadeh,Katayoun Khatami,Pejman Rohani,Maliheh Khodami,Maryam Kazemi Aghdam
- مشاهده
- جایگاه : پژوهشی
- مجله: International Journal of Pediatrics
- نوع مقاله: Journal Article
- کلمات کلیدی: children,Liver Transplantation,Complications,Systematic review
- چکیده:
- چکیده انگلیسی: Introduction: As a standard measure in some chronic liver disorder, liver transplantation (LT) has performed for about 3 decades in pediatric populations. Post operatively some patients suffering from infectious complications by viral, bacterial and fungal etiologies. Here in we presented 10 children diagnosed as bacterial sinusitis presenting with prolonged fever and upper respiratory tract symptoms post LT and review the literature.
Case presentation: Ten pediatric LT recipients including 7 boys and 3 girls, aged 1.5 to 8 years (4.7±2.34) with mean weight of 15.6 Kg (range; 11.4–27.5 Kg) were diagnosed as bacterial sinusitis during December 2013 to March 2017. Patients were suffering from respiratory symptoms and prolonged fever. After ruling out other diagnosis and by performing through investigation, we confirmed bacterial sinusitis by sputum culture and result of antibiogram and paranasal Computed Tomography (CT) scan. All patients dramatically responded to intravenous broad-spectrum antibiotic.
Conclusion: In post LT patients who are, suffering from fever or prolonged fever with upper respiratory signs and symptoms, acute sinusitis should kept in mind. Therefore, timely diagnoses coupled with taking therapeutic measures using broad-spectrum antibiotics could prevent disease progression and complications.- انتشار مقاله: 23-08-1396
- نویسندگان: Naghi Dara,Farid Imanzadeh,Saleheh Tajalli,Amirhossein Hosseini,Seyed Mohsen Dehghani,Aliakbar Sayyari,Katayoun Khatami,Pejman Rohani,Roxana Azma,Mitra Khalili
- مشاهده
- جایگاه : پژوهشی
- مجله: International Journal of Pediatrics
- نوع مقاله: Journal Article
- کلمات کلیدی: risk factors,Iran,Pregnancy,Mother,Neonatal Mortality
- چکیده:
- چکیده انگلیسی: Background: Neonatal death is defined as death at any point in time during the first four weeks of life. It is one of the most important criteria used to evaluate the effectiveness of interventions in public areas. We aimed to investigate pre-pregnancy risk factors associated with neonatal death.
Materials and Methods: This population-based case-control study was conducted in eight provinces and two cities of Iran in 2,788 mothers referred to health care centers during 2015 to 2018. Participants were divided into two cases (1162), and control (1626) groups. Expert staff to interview the participants for case and control groups used a structural interview checklist based on the same protocol. We evaluate the association factor between neonatal mortality, the dependent variable, and the maternal demographic and health status characteristics. Data collection was a multi-stage cluster sampling method. Expert staff interviewed parents to collect data based on the same protocol for case and control groups.
Results: This study was conducted on 2,788 participants, 90% of cases (n=1162), and 94% of controls (n=1626) were under 35 years of age. The chance of neonatal death was higher in Kurdish mothers [OR: 2.02; 95% CI (1.1 – 4.16)], mothers with low level illiteracy [OR: 1.82; 95% CI (1.01 – 3.27)], mothers with previous stillbirth [OR: 8.84; 95% CI (5.88 – 13.29)], using contraceptives [OR: 1.66; 95% CI (1.33- 2.06)], and passive smokers [OR: 1.49; 95% CI (1.20 – 1.86)].
Conclusion: Based on the results, maternal educational level, maternal body mass index, ethnicity, using contraceptives, pregnancy intervals, and history of stillbirth, abortion, and passive smoking were associated with neonatal mortality.- انتشار مقاله: 25-08-1398
- نویسندگان: Tannaz Valadbeigi,Naghi Dara,Hamidreza Tabatabaee,Saleheh Tajalli,Koorosh Etemad,Amirhossein Hosseini,Maryam Ghorbani,Fatemeh Zolfizadeh,Negar Piri,Niloufar Taherpour,Ali Akbar Sayyari,Mohammad Kazemian,Minoo Fallahi,Mahmoud Hajipour
- مشاهده
- جایگاه : پژوهشی
- مجله: Annals of Colorectal Research
- نوع مقاله: Journal Article
- کلمات کلیدی: Constipation,enterocolitis,fecal soiling,Hirschsprung Disease,incontinence pull through surgery
- چکیده:
- چکیده انگلیسی: Background:
A large number of patients who underwent pull-through surgery due to Hirschsprung's disease (HD) were not followed up properly and they suffered from many complications such as fecal soiling, constipation, and etc. Although some of these complications may relief over time, it is rational to consider an evaluative protocol to identify anatomical or pathological complications in these patients. Objective:
The aim of the present study is to evaluate and introduce these catastrophic complications.
Method:
In this historical cohort study, 193 patients with HD who had undergone pull- through surgery between 2006 to 2013 were considered. All files and questionnaires were used to collect patients' information and patients were physically examined individually. The mean duration of the follow-up was 96.4±17.2 months ranging from 60 to 144 months The follow-up performed for all patients via the outpatient clinics or by telephone. All statistical information was analyzed by SPSS software version 17.
Results:
Results:
At first presentation, intestinal obstruction was more frequent than constipation. The most common involved segment was in rectosigmoid. The most common early postoperative complication was stricture in anal canal and the most common late complications were constipation and focal soiling.
Conclusion:
Although surgical advancements, a large number of patients underwent surgical procedures due to HD experience long term complications. Surgical treatment of HD generally present with high-quality outcome and the majority of children survive in satisfactory situation for long time but occasionally pediatric surgeons meet head-on catastrophic complication in these patients that require extended team work to be resolved- انتشار مقاله: 27-07-1399
- نویسندگان: Leily Mohajerzadeh,Ashkan Soltani,Amir Mohammad Zakeri,Ahmad Khaleghnejad Tabari,Mohsen Rouzrokh,Javad Ghoroubi,Mehdi Sarafi,Naghi Dara,Farnoosh Rahimi,Sayeh Hatefi
- مشاهده
- جایگاه : پژوهشی
- مجله: Annals of Colorectal Research
- نوع مقاله: Journal Article
- کلمات کلیدی: laparotomy,Abdominal Abscess,Follow-up studies,Hospitals, Community,Laparoscopy
- چکیده:
- چکیده انگلیسی: Background: Laparoscopy is not an accepted procedure for complicated appendicitis in children for most pediatric surgeons. This procedure is associated with a higher incidence of postoperative abdominal abscess reported in some studies.
Objectives: In this study, we investigated the security, efficacy and complications of laparoscopy in children with complicated appendicitis in Mofid Children's Hospital.
Patients and Methods: From April 2010 to January 2013, we performed laparoscopic appendectomy (LA) in all cases of non-complicated and complicated appendicitis (including perforated appendicitis and localized or generalized peritonitis based on the operation findings and pathological reports). Primary outcomes were incidence of complications, intra-abdominal abscess and wound infection. Secondary outcomes were length of operation, length of hospital stay, resumption of diet, incidence of bowel obstruction, duration of antibiotic use and readmission. Laparoscopy appendectomy was performed with two working ports.
Results: LA was performed in 123 children aged 2 to 14 years (mean of eight years) over a 3-year period, of whom only 34 cases had complicated appendicitis (either localized or generalized peritonitis). There was one conversion to open appendectomy (OA) in a patient with appendicular abscess with a mass, which excluded from our analysis. There were 6 patients with generalized peritonitis and 26 patients with localized abscess, and two patients with appendicular mass. The Average duration of symptoms was four days (ranged 3-6 days). The mean length of operation was 52 minutes (ranged 40-80 minutes). The average length of hospital stay was 4.4 days (ranged 4-7 days). They were able to restart oral intake from 16 to 48 hours postoperatively. Two patients (5%) had postoperative complications; one patient with intra-abdominal abscess who underwent reoperation and the second patient with umbilical wound infection was resolved with antibiotherapy. The average follow-up was 14 months (ranged from 4-36 months).
Conclusions: We recommend laparoscopic approach for all children presenting complicated appendicitis as the initial procedure of choice.
- انتشار مقاله: 13-09-1392
- نویسندگان: Leily Mohajerzadeh,Mohsen Rouzrokh,Ahmad Khaleghnejad Tabari,Alireza Mirshemirani,Khashayar Atqiaee Atqiaee,Naghi Dara
- مشاهده