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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: International Journal of Advanced Biological and Biomedical Research
- نوع مقاله: Journal Article
- کلمات کلیدی: PCR,Sheep,Biochemical,M.ovinpeumoniae,Balochistan
- چکیده:
- چکیده انگلیسی: Mycoplasma ovipneumoniae is an important respiratory pathogen of sheep across the world. In the present study nasal swab samples (n=778) were processed and 51isolates of M. ovipneumoniae were identified through biochemical tests and PCR. Difference in the isolation rate among districts (n=12), age groups (n=3), breads (n=6) was assessed. Similarly the isolate rate among healthy (n=513) and respiratory distressed (n=265) sheep were also compared. The results for the district-wise isolation of Mycoplasma ovipneumoniae in sheep showed non-significant variations among districts of Balochistan (2= 1.65, P=0.9990). Statistically significant difference (2 = 7.698, P< 0.02) in the isolation of Mycoplasma ovipneumoniae among various age groups was recorded, while highest isolation was seen in sheep of < 1 year.Statistically highly significant difference (2 = 16.6, P <0.0050) in the isolation of Mycoplasma ovipneumoniae among various breeds of sheep in Balochistan was seen, whereas highest isolation rate (3.70%) was observed in Harnai breed for sheep Furthermore, statistically highly significant difference (Fisher's exact test P≤0.0001) in the isolation of Mycoplasma ovipneumoniae between healthy and respiratory distressed sheep breeds in Balochistan was found.
- انتشار مقاله: 28-12-1394
- نویسندگان: Shahid Amin,Sajjad Ur Rahman,Iftikhar Hussain,Ghulam Muhammad,Mohammad Arif Awan,Zafer Ahmad,Mohammad Masood Tariq,Muhammad Irfan Ullah,Muhammad Azam Kakar
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Androgen Receptor,AR,Prostatic carcinoma,Gleason score,WHO grade group
- چکیده:
- چکیده انگلیسی: Background: Quantitative immunohistochemical expression of Androgen receptor (AR) has not been evaluated
as a prognostic biomarker of prostate cancer in our population, therefore in the current study we aimed to evaluate
the association of AR expression in prostatic acinar adenocarcinoma with various prognostic parameters like tumor
quantification, Gleason score, WHO grade group and perineural invasion. Methods: Total 121 cases of biopsy proven
prostatic acinar adenocarcinoma were selected from records of pathology department archives from January 2013 till
December 2017. Hematoxylin and eosin stained slides and paraffin blocks were retrieved and new sections were cut
where necessary. Slides of all cases were reviewed by two senior histopathologists and pathologic characteristics like
Gleason score, WHO grade, tumor quantification, perineural and lymphovascular invasion were evaluated. Androgen
receptor immunohistochemistry was applied on all cases. Results: Low AR expression was noted in 53 cases (43.8%)
while high AR expression was seen in 68 cases (56.2%). Significant association of AR expression was noted with total
Gleason score, WHO grade and percentage of tissue involvement (tumor quantification). Univariate binary logistic
regression showed patients with low Gleason scores (scores 6,7 or 8) and low WHO grade (grade 1, 2 or 3) were less
likely to express high AR expression in comparison to high Gleason score (score 9) and high WHO grade group
(grade 5) respectively. Similarly, cases with low tissue involvement by carcinoma (<50%) were less likely to show
high AR expression in comparison to cases with >50% tissue involvement by carcinoma. Conclusion: Significant
association of AR expression was noted with total Gleason score, WHO grade and percentage of tissue involvement
(tumor quantification) which are among the most important markers of tumor progression; therefore we suggest that AR
expression should be performed in patients with prostatic adenocarcinoma for prognostic stratification of the patients.- انتشار مقاله: 07-07-1397
- نویسندگان: Atif Ali Hashmi,Ghazala Mudassir,Muhammad Irfan,Zubaida Fida Hussain,Shumaila Kanwal Hashmi,Huda Asif,Laila Nisar,Maheen Naeem,Naveen Faridi
- مشاهده