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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: immunohistochemistry,Angiogenesis,mast cells
- چکیده:
- چکیده انگلیسی: Objective: To compare mast cell and microvessel densities among histologic grades of oral squamous cell carcinoma. Setting: Armed Forces Institute of Pathology. Materials and Methods: A total of 60 specimens of OSCC comprising 20 each of well, moderately and poorly differentiated were evaluated. Immunohistochemical analysis was performed to measure MCD and MVD by applying monoclonal CD117 antibody and monoclonal CD34 antibody, on formalin fixed and paraffin embedded sections. ANOVA and Post Hoc Tukey test was employed to assess the densities and to compare the differences between different grades of OSCC. A p-value
- انتشار مقاله: 28-03-1399
- نویسندگان: Fakeha Meraj Ansari,Muhammad Asif,Maryam Nazir Kiani,Nighat Ara,Muhammad Ishaque,Rabia Khan
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: CD10,Odontogenic Keratocyst (OKC),Dentigerous cysts,radicular cyst
- چکیده:
- چکیده انگلیسی: Objective: To assess and compare the stromal expression of CD10 in OKC, dentigerous and radicular cysts. Materials
and Methods: This comparative, cross sectional study was conducted at Armed Forces Institute of Pathology (AFIP),
Rawalpindi, from Jan 2017 to Dec 2017. Total sixty cases comprising 20 of each OKC, Dentigerous and Radicular cysts
were included in this study. Hematoxylin and eosin (H and E) sections were performed followed by immunohistochemical
staining for CD10 antibody. Expression of CD10 was evaluated and compared. Results were analyzed by using SPSS
version 20.0. Chi Square test was performed with P value < 0.05 was considered as significant. Results: A total of
60 cases, 20 of each OKC, dentigerous and radicular cysts were taken. In our study, 38 (63.3%) male and 22 (36.7%)
female patients with the mean age of 32 ± 15 (mean ± SD) were included. Percentage of CD10 positive cells were
highest in sub-epithelial stroma of OKC (95% cases) as compared to radicular and dentigerous cysts (60 and 70%) with
highest number of cases showing intense staining in OKC 13(65%) as compared to other odontogenic cysts i-e 4(20%)
and 2 (10%) respectively. There was a statistically significant association between odontogenic cysts and proportional
score, intensity score and combined score of stromal CD10 expression (P=0.009, p=0.001 and p=0.000). Conclusion:
In this study, we found that highest stromal CD10 expression in OKC as compared to dentigerous and radicular cyst,
which might be due to aggressive behaviour and increased risk of recurrence in OKC. Expression of CD10 marker will
further aid the clinician to plan appropriate surgical intervention and keep regular follow-ups to identify recurrences.- انتشار مقاله: 29-05-1397
- نویسندگان: Anam Ali,Muhammad Asif,Bismah Ahmad,Shahid Jamal,Iram Ali,Muhammad Khadim
- مشاهده