در هنگام جستجو کلمه در قسمت عنوان میتوانید کلمات مورد جستجو را با کاراکتر (-) جدا کنید.
کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Breast cancer,Estrogen Receptor,Progesterone Receptor,HER2,low-resources countries
- چکیده:
- چکیده انگلیسی: Aim: The purpose of this study is to evaluate the prevalence of the immunohistochemical subtypes of breast cancer
among Lao women by using immunohistochemistry (according to the St. Gallen 2017 guidelines) and to study their
correlation to clinicopathological features in order to help guide better treatment plans for patients. Materials and
methods: Formalin-fixed and paraffin embedded tissue blocks of 76 cases of primary invasive breast cancer were
retrieved from the University of Health Sciences, Vientiane, Lao PDR, from 2013 to 2016. Patients’ information and
previous histological reports were reviewed. Immunohistochemistry was done using antibodies against estrogen receptor
(ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2/neu) and Ki-67 (MIB-1). Results:
The mean age of the patients was 49 years, and the major histologic type was invasive ductal carcinoma, NOS (90.7%).
The proportion of each subtype was hormone receptor-positive and HER2-negative, 44.7%; hormone receptor-positive
and HER2-positive, 3.9%; hormone receptor-negative and HER2-positive, 13.2%; and triple-negative, 38.2%. ER was
positive in 40.8% of the cases, while PR was positive in 47.4%. More than half of the cases were poorly differentiated
cancer (65.8%), followed by moderately differentiated (34.2%). Tumors presented with pT2 (60.5%), followed by pT3
(25.0%) and pT4 (7.9%). Conclusion: Breast cancer among Lao women is characterized by a large percentage of the
triple-negative subtype that is less susceptible to hormonal treatments. The empirical treatment with tamoxifen should
be reconsidered since it would be less effective to these patients. More importantly, basic pathology services should
be the first requirement in Lao PDR in order to provide adequate care.- انتشار مقاله: 29-05-1397
- نویسندگان: Thitsamay Luangxay,Siriphone Virachith,Kiyomi Hando,Soulideth Vilayvong,Phaengvilay Xaysomphet,Phetsamone Arounlangsy,Keokedthong Phongsavan,Makiko Naka Mieno,Naoko Honma,Masanobu Kitagawa,Motoji Sawabe
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: malignant pleural effusion,Immunocytochemistry,cytological cell transfer,health resource
- چکیده:
- چکیده انگلیسی: Background: Pathology and laboratory medicine (PALM) services are limited in low-resource countries, such as
Lao PDR. Patients with malignant pleural effusion (MPE) are not properly diagnosed and treated in these situations.
The purpose of this study is to confirm the usefulness of immunocytochemistry in MPE to identify the histological
type and probable primary site of cancer of MPE and to discuss its usefulness in low-resource countries, such as Laos.
Methods: We retrospectively reviewed glass slides of pleural effusion sent to the Department of Pathology at the
University of Health Sciences from the central hospitals for cytological screening from January 2012 to December
2016. The cytological review, cell transfer and immunocytochemical staining were performed at Tokyo Medical and
Dental University. Among 81 cases of MPE from Laos, 66 cases of malignant tumors that contained enough tumor
cells were included in this study, and the slides were screened with 14 primary antibodies to classify the histological
type and identify the probable primary site of carcinoma. Results: Among the 66 cases, 34 cases (52%) were of female
patients, and 32 cases (48%) were of male patients. The patients’ ages ranged from 28 to 88 years with an average of 58
years. The immunocytochemical study identified 32 cases (49%) of primary lung adenocarcinoma, two cases (3%) of
malignant mesothelioma, one case (1.5%) of breast/gynecological carcinoma, one case (1.5%) of T cell lymphoma, and
one case (1.5%) of B cell lymphoma. Twenty-nine cases (43.5%) were classified as carcinoma not otherwise specified.
Pulmonary small cell carcinoma/squamous cell carcinoma and metastatic colon, prostate, and liver carcinoma were not
identified among the cases. Conclusions: Immunocytochemistry is a useful ancillary method in MPE diagnostics. This
method could be applied in the pathological laboratories in low- or middle-resource countries, such as Laos.- انتشار مقاله: 26-05-1397
- نویسندگان: Soulideth Vilayvong,Kiyomi Hando,Masaki Sekine,Thitsamay Luangxay,Phetsamone Arounlangsy,Pheangvilay Xaysomphet,Phetlammone Xayaphet,Hatthakone Thavisouk,Yurie Soejima,Masanobu Kitagawa,Motoji Sawabe
- مشاهده