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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Journal of Midwifery and Reproductive Health
- نوع مقاله: Journal Article
- کلمات کلیدی: Ovary,Serous Cystadenoma,Ovarian neoplasm
- چکیده:
- چکیده انگلیسی: While ovarian masses are common findings in gynecology, unusually huge masses are quite rare. However, such cases can still be found today. Mismanagement of common complaints in patients can be a leading cause of facing such findings. Herein, we introduce a case of a giant ovarian cyst, which was mismanaged in a young virgin female patient. The patient had received gastrointestinal medications for months before being admitted to our clinic, given the bloating sensation and lack of any gynecologic problems. Ultrasonography disclosed a giant cyst, probably related to the ovary, originating from the pelvis and extending toward the diaphragm. After a successful surgery, the ovarian cyst, measuring 40 centimeters and weighing 8 kilograms, was removed. Pathology report revealed serous cystadenoma. Existence of such cases can be an alarming sign for physicians to manage prevalent complaints more seriously, particularly those non-responsive to treatment.
- انتشار مقاله: 15-09-1393
- نویسندگان: Jila Agah,Reza Jafarzadeh Esfehani,Batool Kamalimanesh,Mojtaba Fattahi Abdizadeh,Amir Reza Jalilian
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Basic Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: HTLV-1,luciferase,Reporter gene,Biological Assay,Drug screening,Hut102
- چکیده:
- چکیده انگلیسی: Objective(s): Here, a reporter cell line containing two reporter vectors were developed, in order to monitor the Human T-Lymphotropic Virus type1(HTLV-1) infectivity and the cell viability simultaneously.
Materials and Methods: The reporter cell line was constructed by stably transfected baby hamster's kidney cell line (BHK-21), with the genomes expressing two different reporters in separate plasmids.The first reporter gene is transactivated by the HTLV-1 tax protein, while the second reporter is continuously expressed when introduced into a mammalian cell. In order to show its functionality, the effect of the drug mix on HTLV-1 was assayed by this system and was compared to the results obtained by other methods.
Results: HTLV-1 reporter cell line was found to produce high level of luciferase when co-cultured with MT-2 and Hut-102 cells but not with Jurkat cell. Moreover, the combination therapy against HTLV-1 can reduce luciferase expression of the cell when co-cultured with MT-2 and Hut-102 comparable to the ELISA (R=0.932, P-value =0.002). In addition, the results revealed the superiority of the present system over the molecular methods.
Conclusion: The results demonstrated that the biological assay system is a beneficial tool for the medium-throughput anti-HTLV-1 drug screening and inhibitory effect.- انتشار مقاله: 04-07-1396
- نویسندگان: Mojtaba Fattahi Abdizadeh,Manoochehr Makvandi,Alireza Samarbafzadeh,Kayhan Azadmanesh
- مشاهده
- جایگاه : پژوهشی
- مجله: International Journal of Nano Dimension
- نوع مقاله: Journal Article
- کلمات کلیدی: XRD,Drug Delivery,Silica,Magnetite,Acyclovir,Amine functionalized
- چکیده:
- چکیده انگلیسی: Considering many applications of functionalized metal oxide nanoparticles in magnetic resonance imaging, drug delivery, neutron irradiation, electronics, catalysis and optics; herein, a new strategy is developed to functionalize magnetite nanoparticles to improve their performances in the delivery of acyclovir. In this study, magnetite Fe3O4 nanoparticles are synthesized by hydrothermal method. Then, the surface hydroxyl groups were extended by treating with TEOS (tetraethyl orthosilicate); Finally, TMPA (trimethoxysilyl propylamine) was anchored to the surface hydroxyl groups to produce amino-functionalized Fe3O4@SiO2-NH2 magnetic nanoparticles. The synthesized sample was characterized by UV-Vis, FESEM, FT-IR, and XRD. Afterward, the functionalized nanoparticles were examined in the delivery of acyclovir as an active antiviral drug model involving amine and hydroxyl functional groups. For this purpose, the amount of loading/release of the drug was investigated in different pHs, including mouth and stomach pH values. The screened experimental parameters in this study revealed that the prepared magnetite nanoparticles decorated with amine functional groups are successful in the controlled delivery of acyclovir.
- انتشار مقاله: 06-04-1396
- نویسندگان: Reza Tayebee,Mojtaba Fattahi Abdizadeh,Mostafa Mohammadpour Amini,Nasrin Mollania,Zahra Jalili,Hamed Akbarzadeh
- مشاهده