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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: diagnostic accuracy,Pap smear,VIA,VILI,Cervical lesions
- چکیده:
- چکیده انگلیسی: Background: Despite the World Health Organization (WHO) recommendations concerning the use of alternative tests for the detection of cervical cancer precursor lesions in low-income countries, the accuracy of these tests is a debated issue. In the present study we compare the diagnostic accuracy of the triple test with that of colposcopy for the diagnosis of premalignant and malignant cervical lesions. Methods: A cross-sectional study was performed in 328 women referred to the gynecology clinic at Shahid Sadoughi Hospital, affiliated to Yazd University of Medical Sciences (SSUMS), Yazd, Iran, from March 2016 to June 2018. As the first step, a Pap smear was obtained from all participants. Visual inspection with acetic acid (VIA) and Lugol’s iodine (VILI) was performed in accordance with the known protocol. A colposcopy was then conducted in all participants, biopsy samples were obtained, and histological features studied. Finally, the results were compared by statistical analysis. Results: The age range of the participants was 30 - 50 years. Of 328 women, 60 (18.3 %) were postmenopausal. Two-hundred and five patients (62.5 %) had an abnormal Pap smear, 165 (50.3 %) had abnormal results on colposcopy, and 141 (43 %) had abnormal histopathology reports. The VIA was positive in 129 patients (39.3 %) and the VILI in 177 (54 %). The results of the triple test were reported to be positive in 205 cases (51.52 %). The sensitivity of the triple test in the detection of premalignant and malignant cervical lesions was 78.7 % and 69 %, respectively. The sensitivity and specificity of colposcopy in the detection of premalignant and malignant cervical lesions was 80.1 % and 72.2 %, respectively. The diagnostic accuracy of the triple test and colposcopy in the detection of premalignant and malignant cervical lesions was 73 % versus 75 %. Conclusion: Since the results of the study showed that the diagnostic accuracy of the triple test is equivalent that of colposcopy, the former may be used in low-income countries and areas lacking access to colposcopy.
- انتشار مقاله: 30-02-1399
- نویسندگان: Neda Fatahi Meybodi,Mojgan Karimi-Zarchi,Leila Allahqoli,Leila Sekhavat,George Gitas,Azam Rahmani,Arezoo Fallahi,Babak Hassanlouei,Ibrahim Alkatout
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Breast cancer,Meta-Analysis,Polymorphism,Interleukin-10
- چکیده:
- چکیده انگلیسی: Background: The rs1800871 and rs1800872 polymorphisms of interleukin 10 (IL-10) gene has been indicated to
be associated with breast cancer (BC) risk, but study results are still debatable. To derive a more precise evaluation, we
performed a comprehensive meta-analysis. Methods: Multiple electronic databases were searched to identify studies
assessing the IL-10 rs1800871 and rs1800872 polymorphisms with BC risk. Results: A total of 21 case-control studies
with 6054 cases and 6355 controls were included in this met-analysis. There was a significant association between the
rs1800871 polymorphism and BC risk (CT vs. TT: OR= 1.17, 95% CI 1.01-1.35, p=0.02; and CC+CT vs. TT: OR= 1.29,
95% CI 1.00-1.66, p=0.04). Moreover, increased BC risks were also associated with the rs1800872 polymorphism (C
vs. A: OR= 1.29, 95% CI 1.04-1.60, p=0.01; CC vs. AA: OR= 1.54, 95% CI 1.03-2.30, p=0.03; CC+CA vs. AA: OR=
1.43, 95% CI 1.01-2.01, p=0.03; and CC vs. CA+AA: OR= 1.23, 95% CI 1.01-1.51, p=0.04). A pooling of the studies
was also conducted by ethnicity, but failed to show an association of IL-10 rs1800871 and rs1800872 polymorphism
with BC risk in Asians and Caucasians. Conclusions: Our results are inconsistent with previous meta-analysis suggests
that IL-10 rs1800871 and rs1800872 polymorphisms might contribute to BC susceptibility in overall population, but
not by ethnicity.- انتشار مقاله: 24-06-1397
- نویسندگان: Mansour Moghimi,Hossein Ahrar,Mojgan Karimi-Zarchi,Kazem Aghili,Marjansadat Salari,Masoud Zare-Shehneh,Hossein Neamatzadeh
- مشاهده