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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Journal of Patient Safety & Quality Improvement
- نوع مقاله: Journal Article
- کلمات کلیدی: patient safety,Components,Definition
- چکیده:
- چکیده انگلیسی: Patient safety is an important branch of knowledge, which has emerged within the past two decades1. However, the definition and structure of the field remain nebulous despite its wide acceptance and legitimacy. Therefore, it is crucial to define and present the structure of patient safety in order to create a shared image of the concept. Patient safety could be defined as the elimination of damages in patients, as well as a state of no possible harms to patients. In this regard, ‘patients’ and ‘harm’ are defined based on the cultural constructs in different regions and epochs. With the progress of communities, individuals might be included and excluded from the proposed definitions of ‘patients’ and ‘harms’ as these concepts constantly evolve throughout time.
- انتشار مقاله: 10-08-1396
- نویسندگان: Mohd. Nasir Bin Mohd. Ismail,Mohd. Nasir Bin Mohd. Ismail,Mohd. Nasir Bin Mohd. Ismail,Mohd. Nasir Bin Mohd. Ismail
- مشاهده
- جایگاه : پژوهشی
- مجله: Journal of Applied Research on Industrial Engineering
- نوع مقاله: Journal Article
- کلمات کلیدی: Latin hypercube sampling,PID Controller,Polynomial Regression,DC Motor,Simulation Optimization,Computer experiments
- چکیده:
- چکیده انگلیسی: Computational complexity and time-consuming iteration of simulation for tuning of Proportional-Integral-Derivative (PID) controller is a common drawback in many types of existing methods. This paper aims to propose a new method for achieving an optimal design for PID gains parameters with the least number of simulation runs. To achieve this purpose, we combine polynomial regression and Latin Hypercube Sampling (LHS) in order to Design and Analyze of Computer Experiments (DACE). In this method, the LHS is performed three times to design the associated sample points for different usage that includes training sample points to fit polynomial regression as a common surrogate model; validating sample points to scale standardized residuals; grid search sample points for investigating optimal point over whole design space. To show the flexibility and applicability of the proposed method, we serve a numerical case in the tuning of PID controller for linear speed control of Direct Current (DC) motor. Four different polynomial regression fit input/output (I/O) data over separately four model’s performances that includes Integral-Square-Error (ISE), Integral-Absolute-error (IAE), Integral-Time-Square-Error (ITSE), and Integral-Time-Absolute-Error (ITAE). Comparison of the result with two existing approaches such as traditional Zeigler-Nichols method and Taguchi-Gray Relational Analysis (Taguchi-GRA) confirms the reliability and superiority of the proposed method.
- انتشار مقاله: 03-02-1397
- نویسندگان: Amir Parnianifard,Siti Azfanizam Ahmad,Mohd Khairol Anuar Ariffin,Mohd Idris Shah Ismail
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: ADAM Proteins,ADAM9 protein,ADAM9 expression,Uterine cervical carcinoma
- چکیده:
- چکیده انگلیسی: Background: Cervical cancer is a preventable disease caused by human papillomaviruses. It is the third most
common cancer to occur in women of reproductive age. The ADAM9 protein plays a role in basement membrane
degradation and tumour metastasis in certain types of tumour. Thus, it has the potential to become a new targeted
therapy. The objective of this study was to investigate ADAM9 expression in cervical cancer and to determine the
factors associated with ADAM9-positive expression. Methods: This cross-sectional study was conducted in Hospital
Universiti Sains Malaysia (HUSM) Kelantan, Malaysia from December 2010 to December 2012. Histological slides
obtained from 95 cervical cancer cases diagnosed and/or treated in HUSM from 2000 to 2010 were analysed. The
ADAM9 immunostain was then performed on the paraffin blocks. The statistical data entry and analysis were done
using SPSS version 18.0. Multiple logistic regression analysis was performed to determine the factors associated with
ADAM9-positive expression. Result: Of the 95 cervical cancer patients included in the study, 72 (75.8%) patients showed
positive ADAM9 expression. The mean age of the patients was 53.89 (10.83) years old. Squamous cell carcinoma was
the most common type of cervical cancer (n = 67, 70.5%). Factors that showed a statistically significant association
with ADAM9-positive expression were tumour size (adjusted odds ratio [adj. OR]: 1.08; 95% confidence interval
[CI]: 1.02, 1.13; p = 0.004), distant metastasis (adj. OR: 12.82; 95% CI: 1.91, 86.13; p = 0.009) and the histological
type of cervical cancer (i.e. squamous cell carcinoma) (adj. OR: 7.39; 95% CI: 1.42, 38.51; p = 0.017). Conclusion:
The ADAM9 immunostain was consistently positive in malignant cells. Thus, ADAM9 expression can be used as a
prognostic/therapeutic indicator in aiding clinician decision-making regarding patient treatment (targeted therapy).- انتشار مقاله: 27-04-1397
- نویسندگان: Seoparjoo Azmel Mohd Isa,Md Salzihan Md Salleh,Mohd Ismail,Suhaily Mohd Hairon
- مشاهده