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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Journal of Applied Biotechnology Reports
- نوع مقاله: Journal Article
- کلمات کلیدی: cerebellum,Thimerosal,Behavioral Impairments
- چکیده:
- چکیده انگلیسی: Introduction: Existing evidence on the impact of thimerosal (THIM), acting to preserve pharmaceutical products (a preservative), on fetal neurodevelopment is very controversial. Here, we investigated the neonatal administration of THIM on behaviors including (1) locomotor activity, (2) social behaviors, and (3) stereotyped behaviors in rats. Since the development of cerebellum continues for some time after birth and it is very imperative in movement, balance, and sensory integration, the number of cerebellum Purkinje cells also were counted.
Materials and Methods: The experiments were directed on 40 young male and female Wistar rats, which were randomly distributed into 4 groups including experimental (male & female) and control (male & female) groups. Each rat in the test groups were intramuscularly received 240 μg Hg/kg THIM on postnatal days (7, 9, 11, 15), while the control contributors received saline in the same pattern. After drug interventions on the fourth postnatal week, rats were evaluated by open field test, and in eighth postnatal week, the test of three-chamber paradigm was performed on animals. At the end of the behavioral tests, histological studies were done.
Results: Rats which were exposed to the THIM displayed impairments of locomotor activity and their social interactions were reduced. While the duration of freezing/grooming as stereotyped behaviors were increased significantly. The results of histological studies also showed a noteworthy decrease in the number of Purkinje cells in both sexes.
Conclusions: These data prove that early postnatal exposure of children to THIM causes permanent neurobehavioral and histological impairments and if similar alterations occur in children exposed to THIM/mercurial agents, neurodevelopmental disorders may happen.- انتشار مقاله: 06-02-1397
- نویسندگان: Zahra Namvarpour,Abdollah Amini,Mohammad Nasehi,Mohammad-Reza Zarrindast
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Basic Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: Memory,Sleep,Hippocampus,Yohimbine,Clonidine
- چکیده:
- چکیده انگلیسی: Objective(s): Evidence shows that sleep deprivation (SD) disrupts the formation of hippocampus-related memories. Moreover, α2 adrenergic receptors that are wildly expressed in the CA1 hippocampal region have a significant role in modulating both sleep and memory formation. In the present research, we wanted to investigate the effect of stimulation and blockage of CA1 α2 adrenergic receptors by clonidine (an agonist of α2 adrenergic receptor) and yohimbine (an antagonist of α2 adrenergic receptor), respectively, on memory retention impairment induced by REM SD (RSD) in rats.
Materials and Methods: Multiple platform apparatus were used to induce RSD, and the passive avoidance task was used to assess memory consolidation. Clonidine and yohimbine were injected intra-CA1.
Results: The results showed that RSD (for 24 and 36, but not 12 hr) decreased memory retention, with no effect on locomotion. Post-training intra-CA1 infusion of a subthreshold dose of yohimbine (0.001 μg/rat) did not alter, while clonidine (0.1 μg/rat) restored memory retention impairment induced by RSD (24 and 36 hr). Also, none of the interventions did not influence locomotor activity.
Conclusion: Our data strongly showed that CA1 α2 adrenergic receptors have a critical role in RSD-induced memory retention impairment.- انتشار مقاله: 17-09-1398
- نویسندگان: Yaser Norozpour,Mohammad Nasehi,Vahid Sabouri-Khanghah,Mohammad Nami,Salar Vaseghi,Mohammad-Reza Zarrindast
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Basic Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: Memory,Sleep,Hippocampus,Yohimbine,Clonidine
- چکیده:
- چکیده انگلیسی: Objective(s): Evidence shows that sleep deprivation (SD) disrupts the formation of hippocampus-related memories. Moreover, α2 adrenergic receptors that are wildly expressed in the CA1 hippocampal region have a significant role in modulating both sleep and memory formation. In the present research, we wanted to investigate the effect of stimulation and blockage of CA1 α2 adrenergic receptors by clonidine (an agonist of α2 adrenergic receptor) and yohimbine (an antagonist of α2 adrenergic receptor), respectively, on memory retention impairment induced by REM SD (RSD) in rats.
Materials and Methods: Multiple platform apparatus were used to induce RSD, and the passive avoidance task was used to assess memory consolidation. Clonidine and yohimbine were injected intra-CA1.
Results: The results showed that RSD (for 24 and 36, but not 12 hr) decreased memory retention, with no effect on locomotion. Post-training intra-CA1 infusion of a subthreshold dose of yohimbine (0.001 μg/rat) did not alter, while clonidine (0.1 μg/rat) restored memory retention impairment induced by RSD (24 and 36 hr). Also, none of the interventions did not influence locomotor activity.
Conclusion: Our data strongly showed that CA1 α2 adrenergic receptors have a critical role in RSD-induced memory retention impairment.- انتشار مقاله: 17-09-1398
- نویسندگان: Yaser Norozpour,Mohammad Nasehi,Vahid Sabouri-Khanghah,Mohammad Nami,Salar Vaseghi,Mohammad-Reza Zarrindast
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Basic Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: Memory,fear,Prefrontal cortex,tDCS
- چکیده:
- چکیده انگلیسی: Objective(s): Behavioral and neuroimaging studies have shown that transcranial direct current stimulation, as a non-invasive neuromodulatory technique, beyond regional effects can modify functionally interconnected remote cortical and subcortical areas. In this study, we hypothesized that the induced changes in cortical excitability following the application of cathodal or anodal tDCS over the left frontal cortex as pre-training would affect functional connectivity in resting-state circuits of fear memory and consequently could improve or disturb the acquisition of fear memory.
Materials and Methods: In order to evaluate the polarity-dependent effects of tDCS on the acquisition of fear memory and the functional connectivity, we applied left prefrontal anodal or cathodal stimulation at 200 μA for one session to healthy mice for the durations of 20 and 30 min prior to fear conditioning.
Results: Our results revealed that the administration of left prefrontal anodal (for both 20 and 30 min durations) and cathodal (at 30 min duration) tDCS impaired the acquisition of both contextual and cued fear memory. In addition, we did not observe a direct correlation between stimulation duration and the efficacy of tDCS on the acquisition of contextual and cued fear memory.
Conclusion: In this study, the impairments of both contextual and cued memory further confirmed the previous studies reporting that the administration of transcranial stimulation would affect the activity of deeper structures like amygdala and hippocampus as the main components of the fear memory circuit in acquisition, storage, and expression of the memory.- انتشار مقاله: 13-03-1396
- نویسندگان: Shahsanam Abbasi,Mohammad Nasehi,Hamid Reza Soleimanpour Lichaei,Mohammad-Reza Zarrindast
- مشاهده
- جایگاه : پژوهشی
- مجله: Addiction and Health
- نوع مقاله: Journal Article
- کلمات کلیدی: Behavior,Morphine,Correlation study,Administration,Epigenetic
- چکیده:
- چکیده انگلیسی: Background: Critical analysis of new evidence in medical sciences relies on statistics in terms of correlation.
The aim of the present study was to evaluate the correlation coefficients among the behavioral features in the
offspring of morphine-abstinent parent(s).
Methods: The offspring of various types of parental morphine-exposure were divided into 4 groups including
offspring of healthy parents (CTL), offspring of paternal morphine-abstinence (PMA), offspring of maternal
morphine-abstinence (MMA), and offspring of both morphine-abstinence (BMA). Pain perception,
depression-like behavior, and avoidance memory in the offspring were quantified. The logical structure of
association was measured using the Pearson correlation analysis.
Findings: A strong correlation was observed between pain and depressive-like behavior in female and male
offspring of healthy parents. Moreover, in the male and female offspring of healthy parents and BMA, no
significant correlation was observed between avoidance memory and pain behavior or depressive-like
behavior. However, in the offspring of MMA, a strong correlation was observed between avoidance memory
and depressive-like behavior.
Conclusion: The results of the study signified the importance of correlation analysis in addictive behavior. The
results revealed that the pattern of correlation of the behavior of the offspring of MMA and PMA differed- انتشار مقاله: 06-11-1398
- نویسندگان: Hamid Ahmadian-Moghadam,Ardeshir Akbarabadi,Heidar Toolee,Mitra Sadat Sadat-Shirazi,Solmaz Khalifeh,Mohammad-Reza Zarrindast,Saba Niknamfar
- مشاهده