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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Iranian Journal of Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: Hospitals,Proton therapy,Carbon ion radiotherapy,Patient selection, Treatment costs
- چکیده:
- چکیده انگلیسی: Hadron therapy (HT) with protons and carbon ions is an advanced radiotherapy technique. As the first report addressing this topic, the present study aimed to estimate the number of patients eligible for HT in Fars province and the whole of Iran. The data were collected through direct inspection of medical records of the patients treated at the Radiotherapy Department, Namazi Hospital, Shiraz, Iran in 2014. The patients who were treated with external-beam radiotherapy and declared to be a resident of Fars province were extracted from the medical records. After classification based on appropriate indications and factors, the number of eligible patients in Iran was calculated by scaling (Iran: Fars population). Of the 2,932 medical records, 1,943 patients were treated with external-beam radiotherapy, among which 1,536 were from Fars. The total number of patients eligible for HT in Fars was >351 cases/year (22.9% of the treated patients). The cancer site distribution of the eligible Fars residents was central nervous system primary tumors (n=31), brain metastases (n=64), eye (n=7), head and neck (n=28); thyroid (n=4), lung (n=17), breast (n=56), esophagus (n=5); pancreas (n=5), gastric (n=32), liver and bile duct (n=0), rectum and anus (n=26); prostate (n=27), bladder (n=8), cervix (n=6), soft tissue (n=17); kidney (n=1), Hodgkin lymphoma (n=9), non-Hodgkin lymphoma (n=4), and bone metastases (n=4). A total number of 5,756 cases/year was estimated for the entire country. Considering the experiences of other countries, these results suggest that establishing at least two HT centers (covering the northern and southern parts of Iran) is justified based on the total number of patients. Further accurate estimations and cost evaluations are recommended.
- انتشار مقاله: 04-04-1396
- نویسندگان: Mohammad Amin Hosseini,Mohammad Mohamadianpanah,Mohammad Zare-Bandeamiri,Mohammad Amin Mosleh-Shirazi
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: Fistula,Glubran 2,surgical glues,tracheoesophageal atresia with fistula,hypospadias
- چکیده:
- چکیده انگلیسی: Surgical glues have been used in pediatric surgery because of the fragility of tissue, and to prevent major surgeries. The present report describes our experience with using a new cya-noacrylate Glubran 2 (Viareggio, Italy) in the treatment of five cases of tracheoesophageal atresia with fistula (one fistula protection, three recurrent fistula, and one unstable patients), two cases of hypospadias, one case of vesicutanouse fistula after bladder extrophy, and one case of cloacal extrophy from January–December 2008. Three cases of recurrent tracheoesophageal atresia with fistula were treated by bronchoscpic glue injection. The other two cases benefited from glue through its ability to plug the fistula and to act as a protecting layer on anastomosis. In two cases with hypospadias excessive use of the glue caused skin necrosis, which was repaired. The wounds of cloacal extrophy were protected from nearby colostomy con-tamination and infection, and the vesicocutanouse fistula was closed by deepithelialization and sealing with glue. Based on the outcomes of the cases, it may be possible to suggest that Glubran 2 may be used safely in Pediatric Surgery as a sealant for the prevention and treatment of fistulas.
- انتشار مقاله: 02-02-1393
- نویسندگان: Seyed Mohammad Vahid Hosseini,Ali Bahador,Hamid Reza Foroutan,Babak Sabet,Bita Geramizadeh,Mohammad Zarenezhad
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی:
- چکیده:
- چکیده انگلیسی: Biliary atresia is characterized by the progressive obliteration of extra- and intrahepatic biliary duct system leading to the obstruction of bile flow in infancy. The cause(s) of biliary atresia remain unclear and many surgical options for bypassing the atretic segment have been described.1-3 Biliary atresia may be associated with small bowel atresia. The surgical interventions for biliary drainage in this co-morbidity are problematic because of associated inadequate length of bowel for reconstruction while the combined effects of short bowel syndrome and delayed return of adequate motility and absorptive capacity cause the ascending cholangitis.4,5A 2-day-old boy was referred to us because of jaundice, bilious vomiting, and abdominal distension. He was diagnosed as having proximal jejunal atresia. During an operative exploration, the intact remaining of the terminal ileum (10 cm) was anastomosed with proximal pouch (15 cm) end to back fashion but the gall bladder was ignored. He had a good postoperative course and tolerated feeding on the 10 th postoperative day. However, his stool was clay colored and the jaundice persisted. We evaluated him for any surgical causes of neonatal jaundice which showed the absence of gall bladder in abdominal sonography and there was no evidence of excretion of bile into the bowel in HIDA scan. He underwent the second laparotomy and the appendico-duodenostomy was performed for biliary atresia because of a short bowel [figure 1]. The patient developed greenish stool on the 4th postoperative day and discharged with medication.Jaundice in small bowel atresia is not unusual because 20% of cases with small bowel atresia are associated with jaundice.6 The diagnosis of small bowel atresia is definite in all cases at the first glance, but accompanying biliary atresia is not usually detected because of ignoring the gallbladder in all cases during the first operation or having a preoperative ultrasonography without details of the gallbladder. Therefore, we recommend that the gallbladder be examined during the first operation for small bowel atresia. Many techniques for utilizing the appendix as a biliary conduit have been recommended with different results. Appendico-duodenostomy can prevent the reflux cholangitis and save the entire small bowel.7 Therefore, appendix as an anti-reflux conduit, is useful for reconstruction of biliary tree and prevention of ascending cholangitis.
- انتشار مقاله: 17-12-1393
- نویسندگان: Seyed Mohammad Vahid Hosseini,Mohammad Zarenezhad,Soheil Benrazavi
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Basic Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: Leptin,Stem cells,Diabetes Mellitus,Neuropeptide Y,Wharton jelly,Melanocortin,Receptor
- چکیده:
- چکیده انگلیسی: Objective(s): Type 1 diabetes (T1D) is an autoimmune disease resulting from inflammatory destruction of islets β-cells. Nowadays, progress in cell therapy, especially mesenchymal stem cells (MSCs) proposes numerous potential remedies for T1D. We aimed to investigate the combination therapeutic effect of these cells with insulin and metformin on neuropeptide Y, melanocortin-4 receptor, and leptin receptor genes expression in TID.
Materials and Methods: One hundreds male rats were randomly divided into seven groups: the control, diabetes, insulin (Ins.), insulin+metformin (Ins.Met.), Wharton’s Jelly-derived MSCs (WJ-MSCs), insulin+metformin+WJ-MSCs (Ins.Met.MSCs), and insulin+WJ-MSCs (Ins.MSCs). Treatment was performed from the first day after diagnosis as diabetes. Groups of the recipient WJ-MSCs were intraportally injected with 2× 10⁶ MSCs/kg at the 7th and 28th days of study. Fasting blood sugar was monitored and tissues and genes analysis were performed.
Results: The blood glucose levels were slightly decreased in all treatment groups within 20th and 45th days compared to the diabetic group. The C-peptide level enhanced in these groups compared to the diabetic group, but this increment in Ins.MSCs group on the 45th days was higher than other groups. The expression level of melanocortin-4 receptor and leptin receptor genes meaningfully up-regulated in the treatment groups, while the expression of neuropeptide Y significantly down-regulated in the treatment group on both times of study.
Conclusion: Our data exhibit that infusion of MSCs and its combination therapy with insulin might ameliorate diabetes signs by changing the amount of leptin and subsequent changes in the expression of neuropeptide Y and melanocortin-4 receptor.- انتشار مقاله: 24-01-1398
- نویسندگان: Fatemeh Sabet Sarvestani,Mohammad Ali Zare,Forough Saki,Farhad Koohpeyma,Ismail H. Al-Abdullah,Negar Azarpira
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Basic Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: Leptin,Stem cells,Diabetes Mellitus,Neuropeptide Y,Wharton jelly,Melanocortin,Receptor
- چکیده:
- چکیده انگلیسی: Objective(s): Type 1 diabetes (T1D) is an autoimmune disease resulting from inflammatory destruction of islets β-cells. Nowadays, progress in cell therapy, especially mesenchymal stem cells (MSCs) proposes numerous potential remedies for T1D. We aimed to investigate the combination therapeutic effect of these cells with insulin and metformin on neuropeptide Y, melanocortin-4 receptor, and leptin receptor genes expression in TID.
Materials and Methods: One hundreds male rats were randomly divided into seven groups: the control, diabetes, insulin (Ins.), insulin+metformin (Ins.Met.), Wharton’s Jelly-derived MSCs (WJ-MSCs), insulin+metformin+WJ-MSCs (Ins.Met.MSCs), and insulin+WJ-MSCs (Ins.MSCs). Treatment was performed from the first day after diagnosis as diabetes. Groups of the recipient WJ-MSCs were intraportally injected with 2× 10⁶ MSCs/kg at the 7th and 28th days of study. Fasting blood sugar was monitored and tissues and genes analysis were performed.
Results: The blood glucose levels were slightly decreased in all treatment groups within 20th and 45th days compared to the diabetic group. The C-peptide level enhanced in these groups compared to the diabetic group, but this increment in Ins.MSCs group on the 45th days was higher than other groups. The expression level of melanocortin-4 receptor and leptin receptor genes meaningfully up-regulated in the treatment groups, while the expression of neuropeptide Y significantly down-regulated in the treatment group on both times of study.
Conclusion: Our data exhibit that infusion of MSCs and its combination therapy with insulin might ameliorate diabetes signs by changing the amount of leptin and subsequent changes in the expression of neuropeptide Y and melanocortin-4 receptor.- انتشار مقاله: 24-01-1398
- نویسندگان: Fatemeh Sabet Sarvestani,Mohammad Ali Zare,Forough Saki,Farhad Koohpeyma,Ismail H. Al-Abdullah,Negar Azarpira
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Basic Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: IL-10,Preterm delivery,Term delivery
- چکیده:
- چکیده انگلیسی: Imbalanced immune responses against fetus alloantigens can lead to abnormality in pregnancy. Interleukin-10(IL-10) plays key roles in regulation of immune responses against self and foreign antigens to induce tolerance to these antigens. Therefore, alteration in expression of IL-10 during pregnancy may result in several pathologic conditions such as preterm labor. IL-10 leads to a normal pregnancy via several molecular mechanisms including development of tolerogenic dendritic cells, T regulatory lymphocytes and activation of the JAK1/STAT3 pathway in the target cells. This review has collected recent data regarding the status of IL-10 expression during term and preterm deliveries and also its molecular mechanisms that lead to a normal pregnancy.
- انتشار مقاله: 09-12-1394
- نویسندگان: Masoud Mobini,Maryam Mortazavi,Somayeh Nadi,Mohammad Zare-Bidaki,Somayeh Pourtalebi,Mohammad Kazemi Arababadi
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Basic Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: Iran,Polymorphism,CCR5,32 mutation
- چکیده:
- چکیده انگلیسی: Evidence showed that chemokines serve as pro-migratory factors for immune cells. CCL3, CCL4 and CCL5, as the main CC chemokines subfamily members, activate immune cells through binding to CC chemokine receptor 5 or CCR5. Macrophages, NK cells and T lymphocytes express CCR5 and thus, affected CCR5 expression or functions could be associated with altered immune responses. Deletion of 32 base pairs (D 32) in the exon 1 of the CCR5 gene, which is known as CCR5 D 32 mutation causes down regulation and malfunction of the molecule. Furthermore, it has been evidenced that three polymorphisms in the promoter region of CCR5 modulate its expression. Altered CCR5 expression in microbial infection and immune related diseases have been reported by several researchers but the role of CCR5 promoter polymorphisms and CCR5 D 32 mutation in Iranian patients suffering from these diseases are controversial. Due to the fact that Iranian people have different genetic backgrounds compared to other ethnics, hence, CCR5 promoter polymorphisms and CCR5 D 32 mutation association with the diseases may be different in Iranian patients. Therefore, this review addresses the most recent information regarding the prevalence as well as association of the mutation and polymorphisms in Iranian patients with microbial infection and immune related diseases as along with normal population.
- انتشار مقاله: 13-02-1394
- نویسندگان: Mohammad Zare-Bidaki,Masoud Karimi-Googheri,Gholamhossein Hassanshahi,Nahid Zainodini,Mohammad Kazemi Arababadi
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Biotechnology
- نوع مقاله: Journal Article
- کلمات کلیدی: Prostate cancer,Polymorphism,PCR-RFLP,PCR-SSCP,ABCC1,Codon 72 p53
- چکیده:
- چکیده انگلیسی: Background: In prostate cancer, mutated p53 alleles typically contain missense single-base substitution in codon 72 that resides within exons 5-8. Stable p53 proteins in tumor cell nuclei have been associated with malignancy. A role of p53 is the regulation of drug transporters like ABCC1 (MRP1) by an effect on promoter region. Objectives: The objective of this study was to identify association of mutations of p53 at codon 72 and 282 and promoter region of ABCC1 with increased risks of prostate cancer. Materials and Methods: Formalin fixed, paraffin-embedded malignant tissues of 45 patients and 45 control samples were evaluated. PCR-RFLP using BstUI for codon 72 and HpaII restriction enzyme for codon 282 p53 gene, and G-1666A promoter region of ABCC1 gene was performed. To assess the frequency of these mutations and to detect new mutations in cancerous samples, PCR-SSCP analysis was performed. Results: The frequencies of CC, GC and GG genotypes of codon 72 of p53 were 33.33%, 46.67% and 20.00% in patients with cancer and 15.56%, 48.89% and 35.55% in controls, respectively. The relative allele frequencies of ABCC1 promoter polymorphism were 60.00% A and 40.00% G in patients as opposed to 37.78% for A and 62.22% for G in controls. Genotypic frequencies of p53 codon 72 and G1666A of ABCC1 in patients vs. Controls were statistically significant(p<0.05). The study of these samples with PCR-SSCP displayed some new banding patterns. Conclusions: The present findings suggest that CC homozygosity in codon 72 of p53 gene and AA genotype in G-1666A of ABCC1 gene may play a role in combination in prostate cancer and increased susceptibility for this malignancy in the Iranian Kurdish population.
- انتشار مقاله: 15-09-1393
- نویسندگان: Farinaz Behfarjam,Jalal Rostamzadeh,Mohammad Ali Zarei,Bahram Nikkhoo
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Catalysis
- نوع مقاله: Journal Article
- کلمات کلیدی: Solid acid,2,Heterogeneous catalysis,Sulfonated Porous Carbon,3 dihydroquinazolin-4(1H)-ones
- چکیده:
- چکیده انگلیسی: A simple and efficient procedure has been developed for the synthesis of 2,3-dihydroquinazolin-4(1H)-ones derivatives under solvent-free conditions. This method uses the condensation of isatoic anhydride, aldehydes, and amines in the presence of a catalytic amount Sulfonated Porous Carbon (SPC). One of the important advantages of the new method is that the SPC could be recycled and reused.
- انتشار مقاله: 02-04-1391
- نویسندگان: Arash Shokrolahi,Abbas Zali,Mohammad Ali Zarei,Karim Esmaeilpour
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Chemistry and Chemical Engineering
- نوع مقاله: Journal Article
- کلمات کلیدی: Green chemistry,nanocatalyst,Organic synthesis,Sulfonated magnetic nanoparticles,Recyclability
- چکیده:
- چکیده انگلیسی: Sulfonated magnetic nanoparticles (SO3H-Fe3O4@SiO2 MNPs) have been explored as an efficient, cost-effective, and recyclable nanocatalyst for the facile synthesis of 3,4-dihydro-2H-indazolo[1,2-b]phthalazin-1,6,11(13H)-triones through a one-pot three-component reaction between aldehydes, dimedone, and phthalhydrazide under mild and green (solvent-free) conditions. Simple separation of the catalyst using an external magnet, efficient recyclability of the developed magnetic nanocatalyst up to five fresh runs without significant loss in its catalytic activity, excellent yields of the designed reactions (88 to 98%), low reaction times as well as solvent-free and facial reaction condition are some advantages of the present procedure that qualified the fabricated magnetic nanocatalyst for industrial applications.
- انتشار مقاله: 11-02-1397
- نویسندگان: Mohammad Reza Zare,Davood Azarifar,Omolbanin Badalkhani,Mehdi Jaymand
- مشاهده