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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: International Journal of Pediatrics
- نوع مقاله: Journal Article
- کلمات کلیدی: children,Baclofen,Gastroesophageal Reflux,Proton pump inhibitor
- چکیده:
- چکیده انگلیسی: Background
Gastroesophageal Reflux is a physiological phenomenon, which occurs in infants, children, and normal adults. Various studies have shown that Baclofen is a potent inhibitor of lower esophageal sphincter and has beneficial effects in adult reflux disease. We aimed to evaluate the Baclofen effect in pediatric Gastroesophageal disease.
Materials and Methods: Children 6 months to 12 years old, with Gastroesophageal reflux disease were enrolled in this Clinical trial study. Patients referred to Taleghani Children’s Center in Gorgan, Golestan province, Iran from May to August 2019. Patients were randomly divided into two intervention group and control group. The controls received only proton pump inhibitor 1 mg per kg treatment, and intervention group received proton pump inhibitor (PPI) plus baclofen 0.25 mg per kg two times per day. Patient data including age, gender, family history, growth status, reflux symptoms, previous drug treatment history, and symptoms in two groups, were compared.
Results: Fifty-four patients in the baclofen treatment group and 58 patients in the non-baclofen treatment group were included. The mean age of the patients was 6.61+ 3.55 years. The most common symptoms of all patients were abdominal pain (73.2%), nausea (73.2%), regurgitation (64.3%), and dental erosion (55.4%). The rate of recovery was significantly related to gender, with 69.9% of patients having moderate to full recovery (p = 0.017). Weight gain in baclofen treated group was significantly higher.
Conclusion: The results suggest that baclofen along with routine Gastroesophageal reflux treatments in children can help reduce or improve symptoms of the disease. Due to limited studies, further studies are needed to confirm the positive effect of this drug with higher sample size.- انتشار مقاله: 24-12-1398
- نویسندگان: Mohammad Sobhani Shahmirzadi,Leila Barati,Mohsen Ebraimi,Khatereh Shiroodbakhshi
- مشاهده
- جایگاه : پژوهشی
- مجله: Advanced Herbal Medicine
- نوع مقاله: Journal Article
- کلمات کلیدی: Acute liver failure,Cassia floribunda,senna,case series
- چکیده:
- چکیده انگلیسی: Liver is the largest and most vital organ in human body and able to detoxify several chemical compounds. Acute liver failure (ALF) is a rare devastating process that can leads to urgent liver transplantation. In this study we introduce 3 children of a family with an accidental intoxication of Cassia Floribunda which causes ALF. The first case is a four-year-old girl with an icter's complaints and drowsiness after eaten plant in the garden while playing with her sister and friend 3 days ago. At the beginning her GCS was 10, vital signs were normal, sclera was icteric and pupil has normal size and was reactive to the light. Initial tests showed leukopenia, anemia, thrombocytopenia, increase of liver enzymes , coagulopathy , hypoglycemia. With diagnosis, fulminant liver deficiency and hepatic encephalopathy, the patient transferred to PICU and GCS reduced. her general appearance became better ,consciousness increased, lab test findings improvedand and discharged after 11 days.Second and third cases presented to emergency with similar complaints without icteric, vital signs and other examinations were normal . Initial tests reported reduced platelets, increase liver enzymes , Without hypoglycemia. treatment was started for patient by intravenous ranitidine and monitored in emergency . Two days after discharged. But in third case platelets increased.ALF in children is a serious problem that can lead to death or need to liver transplantation. When evaluate the causes of ALF, poisoning due to plants should be kept in.
- انتشار مقاله: 20-06-1396
- نویسندگان: Maryam Montazeri,Mohammad Sobhani Shahmirzadi,Samane Sharifi Najjari,Mohammadreza Ebadpour
- مشاهده