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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Iranian Journal of Pharmaceutical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: essential oil,bornyl acetate,Juniperus chinensis,sabinene,trans-Sabinyl acetate
- چکیده:
- چکیده انگلیسی: The composition of essential oil of leaves of the male and female shrubs of Juniperus chinensis L. (growing in Isfahan) was analyzed by gas choromatography(GC) and GC-mass spectrometery (MS). The main constituents of leaf oil of the male shrub were: bornyl acetate (26.1%), sabinene (18.3%), trans-sabinyl acetate (11.1%), myrcene (9.2%), limonene (6.1%), elemol (5.5%), α-cadinol (2.3%), δ-cadinene (2.2%), trans-thujone (1.6%), α-pinene (1.3%) and α-muurolol (1.1%); while the major constituents of leaf oil of the female shrub were: sabinene (18.0%), bornyl acetate (12.3%), carotol (11.4%), elemol (9.9%), myrcene (8.8%), α-pinene (6.4%), δ-cadinol (4.8%), limonene (3.9%), δ-cadinene (3.4%) and α-muurolol (2.7%).
- انتشار مقاله: 04-10-1385
- نویسندگان: Suleiman Afsharypuor,Mohammadreza Rahiminezhad,Leili Ghaemmaghami,Majid Soleimani Soleimani,Mohammadreza Khanmohammadic,Neda Afsharipour
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Pathology
- نوع مقاله: Journal Article
- کلمات کلیدی: Lacrimal sac,Nasolacrimal Duct,Epiphora,Dacryocystorhinostomy
- چکیده:
- چکیده انگلیسی: Background and Objectives: External dacryocystorhinostomy (DCR) is the method of choice to treat nasolacrimal duct (NLD) obstruction and the other approaches are compared with it, with a failure rate of 4% to 13%. The current study aimed to assess the causes of failure in external DCR by postoperative endoscopic and pathological evaluation.
Methods: The current retrospective cross sectional study followed-up113 patients with external DCR and silicone intubation for three months. Silicone tubes were removed after the third months. Failure was confirmed based on the clinical findings and irrigation test. Paranasal sinus computed tomography (CT) scanning, and endoscopic and pathological evaluations were performed in the failed cases.
Results: Totally, 113 patients underwent external DCR. The patients included 71 females and 42 males. The mean age of the patients was 55.91 years; ranged from 18 to 86. Epiphora was the most common complaint before surgery (90.3%). Clinically, epiphora continued in 17 cases (15%), of which 94.11% had at least one sinus CT abnormality and 82.35% had at least one endoscopic abnormality. The most common endoscopic findings were deviated septum (70.6%), scar tissue (52.94%), concha bullosa (46.9%), septal adhesion (47.05%), enlarged middle turbinate (41.2%), and sump syndrome (11.7%). The failure was significantly associated with the chronicity of the initial symptoms (P-value=0.00). Pathologically, there were significant relationship amongst the failure rate, scar formation, and allergic rhinitis (P-values =0.00 and <0.05, respectively).
Conclusion: Preoperative endonasal evaluation and consultation with an otolaryngologist can improve surgical outcomes and help to have a better conscious to intranasal abnormalities before external DCR surgery.- انتشار مقاله: 30-11-1394
- نویسندگان: Hassan Ghasemi,Sajedeh Asghari Asl,Mohammad Ebrahim Yarmohammadi,Farhd Jafari,Pupak Izadi
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Pathology
- نوع مقاله: Journal Article
- کلمات کلیدی: Goblet cell,Lacrimal Duct Obstructions,Inflammations
- چکیده:
- چکیده انگلیسی: Background and Objectives: Primary acquired nasolacrimal duct obstruction (PANDO) is a common ocular problem. Clinical presentation can range from simple tearing to a life-threatening condition. The exact pathophysiology of obstruction is not completely understood. In this study, therelationship between PANDO and nasal mucosal goblet cells was investigated. Materials & Methods: In this case-control study, 15 subsequent patients with PANDO were enrolled. Patients were operated with endoscopic dacryocyctorhinostomy. A small piece of nasal mucosal biopsy sample was obtained from inferior turbinate. The samples were prepared and stained for mucin. Goblet cells were counted in the specimens. The results were compared with the nasal mucosa of 15 normal persons who were underwent rhinoplasty surgery as control group. Data were analyzed by SPSS version 16 software and were assessed using t-test, analysis of variance, and Pearson correlation test. Results:In patients group, 13 cases (86.7%) were female and 2 cases (13.3%) were male. The mean age was 42.4±14.3 years (range, 23-68 years). In control group, 9 persons (60%) were female and 6 persons (40%) were male. The mean age was 35.5±12.1 (range, 19-58 years) (P>0.05). All patients had epiphora, and 66.7% of patients had purulent discharge. Duration of symptoms ranged from 1 year to 12 years. The number of goblet cells of the nasal mucosa in patient group was significantly higher than the control group (P<0.001). Inflammation was not related to goblet cell numbers Conclusion: According to findings of this study, goblet cells have important role in inflammatory process and perhaps obstruction in nasolacrimal duct.
- انتشار مقاله: 29-06-1393
- نویسندگان: Hassan Ghasemi,Mohammad Ebrahim Yarmohammadi,Farhad Jafari,Pupak Izadi,Mahdi Faryadras
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Pathology
- نوع مقاله: Journal Article
- کلمات کلیدی: ELISA,Nasal,Paranasal,TGFβ1
- چکیده:
- چکیده انگلیسی: Background and Objectives: Nasal polyposis is a diseases resulting from complex pathogenetic mechanisms. Some studies showed that TGFβ1 had significant role in this pathogenesis. In this study, we investigated the roe of cytokines and mediators in polyp development. Material and Methods: In this case- control study, healthy nasal mucosal samples were obtained from 24 people undergoing septoplasty or rhinoplasty and polyp samples were obtained from 15 patients with nasal and paranasal sinuses polyposis undergoing endoscopic sinus surgery. TGFβ1 concentration was measured with ELISA in homogenized polyp and control samples. The difference of the mean concentrations was analyzed with Mann-Whitney test. Results: We detected TGFβ1 in 11 patients’ samples and in 22 control samples. There was not significant differentiation between the mean of TGFβ1 levels in two groups. Conclusion: Measuring level of TGFβ1 with ELISA technique in homogenized polyp and control samples have not significant differentiation.
- انتشار مقاله: 05-07-1393
- نویسندگان: Mohammad Ibrahim Yarmohammadi,Horieh Saderi,Pupak Ezadi,Siamak Afshin Majad,Maryam Hashemi
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Pathology
- نوع مقاله: Journal Article
- کلمات کلیدی: Cytomegalovirus,Sinusitides,Polymerase Chain Reactions
- چکیده:
- چکیده انگلیسی: Background and Objective: Sinusitis is one of the most common hygienic problems and a large part of the budget has been allocated to its diagnosis and treatment yearly. In this study, the presence of cytomegalovirus in sinuses of patients, undergone operation for treatment, with or without sinusitis, was studied. Materials and Methods: This study was an applied and case-control study, which had been performed on 44 HIV negative patients in ENT clinic of Shahid Mostafa Khomeini Hospital in Tehran during 4 months in 2005.Biopsy specimens were taken from left and right of uncinet process mucosa of middle meatus of 22 patients with chronic sinusitis and 22 patients without sinusitis undergo operation for nasal septal deviation. After purification of DNA, PCR test was done for replication of early gene in cytomegalovirus DNA by two kits, which was purchased from Cinnagen Co. and Gen Fanavaran Co. Results: After the electrophoresis of PCR product on agarose gel, neither of samples has shown DNA band same the positive control enclosed in kits. Therefore, all specimens were considered negative for cytomegalovirus DNA. Conclusion: Cytomegalovirus has not been detected in sinunasal mucosa of patients with chronic sinusitis and without sinusitis. Test with more specimens and other diagnostic procedure are recommended for prove of absence of cytomegalovirus in sinunasal mucosa.
- انتشار مقاله: 06-07-1393
- نویسندگان: Mohammad Ebrahim Yarmohammadi,Horieh Saderi,Tahere Shahrokhtabar
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Pathology
- نوع مقاله: Journal Article
- کلمات کلیدی: PCR,Helicobacter pylori,chronic sinusitis,Urease Test
- چکیده:
- چکیده انگلیسی: Objective: To investigate the presence of Helicobacter pylori in sinonasal mucosa of patients with chronic sinusitis Design: A prospective case-control study Materials and methods: Mucosal specimens were collected from the mid-third middle meatus and lateral side of mid-cornea. H. pylori has been investigated using PCR after DNA extraction and urease test. Results: H. pylori was not found in any of the sample taken from both groups (case and control patients). Conclusion: This is the first reported study to investigate the presence of H. pylori in sinonasal mucosa in Iran. In this study, H. pylori was not determined in these sites, although its possible presence could not be excluded. Thus, further investigation on more patients and application of sensitive diagnostic techniques are recommended.
- انتشار مقاله: 06-07-1393
- نویسندگان: Mohammad Ebrahim Yarmohammadi,Horieh Saderi,S.Hadi Saghelaini,Jamshid Narenjkar J
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Otorhinolaryngology
- نوع مقاله: Journal Article
- کلمات کلیدی: Squamous Cell Carcinoma,Lymph node,Mouth,submandibular gland,Glossectomy
- چکیده:
- چکیده انگلیسی: Introduction:
Submandibular gland resection is a controversial issue in patients with oral tongue squamous cell carcinomas (SCC). This study aimed to determine the frequency of submandibular gland involvement in patients who had undergone elective submandibular gland resection following oral tongue SCC.
Materials and Methods:
This cross-sectional retrospective study was performed between 2001 and 2017 on patients with oral tongue SCC who had undergone glossectomy in a referral center for otorhinolaryngology surgery, Shiraz, Iran.
Results:
In this study, 131 patients were included. Their mean age was 59.84 years (range: 19-86). The mean tumor size was 2.83 cm (range 0.3-7). The vast majority (92%) of the patients were at stage III-IVa and had well (55%) to moderate (31%) differentiated tumor. The mean diameter of the submandibular gland was 3.87 cm (range: 1.5-6 cm). There was only one (0.76%) patient with submandibular involvement. She was an 80-year-old woman with a T2 well differentiated tumor without cervical lymph node involvement in the neck node dissection.
Conclusion:
In patients with oral tongue SCC, submandibular gland involvement is rare and its elective resection in not recommended.- انتشار مقاله: 16-08-1398
- نویسندگان: Shadi Javadi,Bijan Khademi,Mohammad Mohammadianpanah,Mahmoud Shishegar,Amirhossein Babaei
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Otorhinolaryngology
- نوع مقاله: Journal Article
- کلمات کلیدی: Methods,Canal well down,Meatoplasty
- چکیده:
- چکیده انگلیسی: Introduction:
Meatoplasty is the final and essential step in performing effective canal wall down surgery for chronic otitis media. In this article we review some previous techniques and discuss our preferred method.
Materials and Methods:
In this observational case series study, we used this technique in 53 patients (28 male and 25 female) between January 2005 and January 2008. Our survey was completed in 31 patients.
Results:
Twenty-six patients (83.9%) said their ear appeared normal after the procedure, but five patients (16.1%) complained of some minor change in the shape of their ear. Twenty-nine patients (93.5%) had a completely wide ear canal. The ear canal had some degree of stenosis in two patients (6.5%) post-operatively.
Conclusion:
This technique offers good functional and cosmetic results with minimal manipulation and minimal anatomic disruption.- انتشار مقاله: 11-11-1394
- نویسندگان: Faramarz Memari,Mojtaba Maleki Delarestaghi,Parisa Mir,Mohammad GolMohammadi,Ehsan Shams Koushki
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Otorhinolaryngology
- نوع مقاله: Journal Article
- کلمات کلیدی: children,Stigma,Hearing loss,Mother
- چکیده:
- چکیده انگلیسی: Introduction:
A deaf child creates a feeling of stigma in many hearing parents. Stigma in mothers can have a negative impact on a child’s treatment and rehabilitation process. Therefore, this study was conducted to evaluate the extent of stigma in mothers with deaf children.
Materials and Methods:
This descriptive, cross-sectional study was conducted in 2013 among 90 mothers with deaf children. The data-collection instrument included the stigma scale in the mothers of children with disabilities. The reliability and validity of the instrument were confirmed through content validity and Cronbach’s alpha coefficient (α=86%), respectively. Data were analyzed using SPSS-15 software.
Results:
Results showed that most mothers suffer from stigma due to having a deaf child. The mean stigma score was 96.48 ±27.72. In total, 24.4% of mothers reported that they had received strange and mocking looks; 72.2% regarded child deafness as a sign of divine retribution; and 33.3% felt ashamed of their child’s deafness. There was an inverse relationship between the mother’s level of education and mean stigma scores (P<0.033). The stigma score was higher in mothers who were living independently of their relatives (P<0.029). The mean stigma score in mothers of children with a cochlear implant was lower than that of mothers of children with earphones (86.70 vs. 99.64), and this difference tended towards significance (P=0.057).
Conclusion:
This study showed that half of all mothers with deaf children were scorned and felt ashamed of having a deaf child in the family because of the stigma. The majority of mothers with deaf children felt stigmatized, and only their education and residency status affected this issue. The mothers of cochlear-implanted children perceived less stigma. Due to the various social and psychological problems caused by hearing impairment, it is necessary to consider the emotional health and psychological state of the mothers in addition to rehabilitation programs and standard services for the children themselves.- انتشار مقاله: 30-01-1393
- نویسندگان: Hossein Ebrahimi,Eissa Mohammadi,Mohammad Ali Mohammadi,Akbar Pirzadeh,Hamzeh Mahmoudi,Ismail Ansari
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Otorhinolaryngology
- نوع مقاله: Journal Article
- کلمات کلیدی: children,Ketamine,Postoperative pain,Tonsillectomy
- چکیده:
- چکیده انگلیسی: Introduction: Tonsillectomy is one of the most common surgical operations and has such complications as pain, hemorrhage and laryngospasm. Pain management is of vital importance in order to reduce the suffering and restlessness in children having undergone tonsillectomy. Different studies differ in their findings as to the use of ketamine for postoperative analgesia. The aim of this study was to investigate the effect of peritonsillar injection of ketamine preoperatively on postoperative pain relief. Materials and Methods: This was a randomized controlled trial (RCT) on sixty 3-12-year-old children. Children were randomly assigned to the intervention and control groups. Peritonsillar injection consisted of 1 mg/kg ketamine in the intervention group and of normal saline in the control group. An injection of 1 cc was administered on each side five minutes prior to tonsillectomy. Pain assessment was performed using the self-report Oucher Scale and CHEOPS (Children's Hospital of Eastern Ontario Pain Scale) and sedative state assessment was performed using the Wilson Sedation Scale. Pain, medication and complications were studied for 24 hours. Data analysis was performed using chi-squared test and t-test. Results: The ketamine group had a lower pain score compared with the control group (1.40±1.003 compared with 1.53±1.074). The average pain was less in the control group two hours after the surgery. The difference was statistically significant. There was no difference between the two groups in terms of nausea and vomiting incidence. Conclusion: The peritonsillar injection of ketamine five minutes prior to the surgery reduces the post-tonsillectomy pain without causing any complications.
- انتشار مقاله: 29-03-1390
- نویسندگان: Akbar Pirzadeh,Mohammad Ali Mohammadi,Sooreh Allaf-Akbari,Masood Entezariasl
- مشاهده