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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Addiction and Health
- نوع مقاله: Journal Article
- کلمات کلیدی: Opium,oral cancer,P53 genes, EGFR genes
- چکیده:
- چکیده انگلیسی: Background: Although evidence indicates that tobacco use is one of the risk factors for oral cancer, the relationship between opium addiction and oral cancer has not yet been evaluated. The present study was performed aiming to evaluate P53 and epidermal growth factor receptor (EGFR) expression in the gingival tissue of opium-dependent patients.Methods: 102 individuals (70 men and 32 women) were entered in the study. 63 and 39 individuals were included in the opium-dependent group and opium-independent group (control group), respectively. 1 gingival biopsy was taken from each individual. The biopsies were fixed in 10% buffered formaldehyde solution and embedded in paraffin at 56 ̊C. The slides were then stained with Hematoxylin-Eosin (H & E) and Immunohistochemistry (IHC) evaluation was performed with the antihuman antibodies of P53 and EGFR. The protein expression level was later assessed and data were analyzed statistically.Findings: P53 expression was higher among the opium-dependent group, however the difference was not statistically significant (P = 0.052). EGFR expression was significantly higher among the opium-dependent group compared to the control group (P = 0.006).Conclusion: Opium dependency significantly affects EGFR expression in gingival tissue, however it seems to have no significant effect on P53 expression.
- انتشار مقاله: 19-12-1396
- نویسندگان: Mohammad Mohammadi,Najmeh Asghari,Mahtab Hashemipoor,Shima Borji,Molouk Torabi
- مشاهده
- جایگاه : پژوهشی
- مجله: Addiction and Health
- نوع مقاله: Journal Article
- کلمات کلیدی: harm,Substance addiction,Prevention,content analysis,high school,Curriculum,Causes
- چکیده:
- چکیده انگلیسی: Background: This research sought to determine how well the causes of addiction, addiction harms, and prevention of addiction have been noticed in high school textbooks.Methods: We used descriptive method to select the main related components of the addiction concept and content analysis method for analyzing the content of textbooks. The study population comprised 61 secondary school curriculum textbooks and study sample consisted of 14 secondary school textbooks selected by purposeful sampling method. The tools for collecting data were “content analysis inventory” which its validity was confirmed by educational and social sciences experts and its reliability has been found to be 91%. About 67 components were prepared for content analysis and were divided to 3 categories of causes, harms, and prevention of addiction. The analysis units in this study comprised phrases, topics, examples, course topics, words, poems, images, questions, tables, and exercises.Findings: Results of the study showed that the components of the addiction concept have presented with 212 remarks in the textbooks. Also, the degree of attention given to any of the 3 main components of the addiction concept were presented as follows: causes with 52 (24.52%) remarks, harm with 89 (41.98%) remarks, and prevention with 71 (33.49%) remarks.Conclusion: In high school textbooks, little attention has been paid to the concept of addiction and mostly its biological dimension were addressed while social, personal, familial, and religious dimensions of addiction have been neglected.
- انتشار مقاله: 13-04-1396
- نویسندگان: Mohammad Hasan Mirzamohammadi,Sayedeh Zainab Mousavi,Omid Massah,Ali Farhoudian
- مشاهده