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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Iranian Journal of Medical Physics
- نوع مقاله: Journal Article
- کلمات کلیدی: Serum,survival rate,Radiation Effects,Adaptive response
- چکیده:
- چکیده انگلیسی: Introduction: Adaptive response is one of the important concepts in radiobiology. The present report aimed to transfer the radio-adaptation via serum.
Material and Methods: In total, 50 male adult Wistar rats were randomly divided into 6 groups, including control, serum control, low-dose (100cGy), low-dose/lethal, serum/lethal, and lethal (8Gy). Exposure was carried out by a linear accelerator (Elekta Synergy® Platform) with a 40×40cm field size. The animals were monitored in terms of the endpoints of the survival rate, and at the first stage, the rats were exposed to the low doses of radiation. Subsequently, the serum was injected intraperitoneally under sterile conditions 6 h after low-dose exposure. The Kaplan Meier Survival Curve was used to evaluate the survival rate (p <0.05).
Results: There was a significant difference among different groups regarding the survival rates. Moreover, a statistically significant difference was observed between low-dose/lethal and low-dose/serum, low-dose/lethal and lethal, and low-dose/serum and lethal (P=0.001). Similarly, there was a statistically significant difference between the control and experimental groups regarding the survival rates (P=0.001).
Conclusion: To the best of our knowledge, this method can lead to immunological responses or unknown mechanisms that result in the increased survival adaptive response to subsequent high-dose radiation.- انتشار مقاله: 02-02-1398
- نویسندگان: Ehsan Khodamoradi,Rasool Azmoonfar,Mohammad Mohammadi,Amir Kiani,Abbas Haghparast,Nasrin Sharafi,Loghman Diojan
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Oil and Gas Science and Technology
- نوع مقاله: Journal Article
- کلمات کلیدی: Adsorption,Desulfurization,Denitrogenation,Equilibrium and Kinetics Model,PSO-ANFIS
- چکیده:
- چکیده انگلیسی: This study presents a robust and rigorous method based on intelligent models, namely radial basis function networks optimized by particle swarm optimization (PSO-RBF), multilayer perceptron neural networks (MLP-NNs), and adaptive neuro-fuzzy inference system optimized by particle swarm optimization methods (PSO-ANFIS), for predicting the equilibrium and kinetics of the adsorption of sulfur and nitrogen containing compounds from a liquid hydrocarbon model fuel on mesoporous materials. All the models were evaluated by the statistical and graphical methods. The predictions of the models were also compared with different kinetics and equilibrium models. The results showed that although all the models lead to accurate results, the PSO-ANFIS model represented the most reliable and dependable predictions with the correlation coefficient (R2) of 0.99992 and average absolute relative deviation (AARD) of 0.039%. The developed models are also able to predict the experimental data with better precision and reliability compared to literature models.
- انتشار مقاله: 16-03-1398
- نویسندگان: Mohammadreza Khosravi-Nikou,Ahmad Shariati,Mohammad Mohammadian,Ali Barati,Adel Najafi-Marghmaleki
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: Automobile driving,Accidents,Human Factors,Personality,mental disorders,Bus and truck drivers
- چکیده:
- چکیده انگلیسی: Background: The aim of this study was to evaluate the effect of variables such as personality traits, driving behavior and mental illness on road traffic accidents among the drivers with accidents and those without road crash.Methods: In this cohort study, 800 bus and truck drivers were recruited. Participants were selected among drivers who referred to Imam Sajjad Hospital (Tehran, Iran) during 2013-2015. The Manchester driving behavior questionnaire (MDBQ), big five personality test (NEO personality inventory) and semi-structured interview (SADS) were used. After two years, we surveyed all accidents due to human factors that involved the recruited drivers. The data were analyzed using the SPSS software by performing the descriptive statistics, t-test, and multiple logistic regression analysis methods. P values less than 0.05 were considered statistically significant.Results: In terms of controlling the effective and demographic variables, the findings revealed significant differences between the two groups of drivers that were and were not involved in road accidents. In addition, it was found that depression and anxiety could increase the odds ratio (OR) of road accidents by 2.4- and 2.7-folds, respectively (P=0.04, P=0.004). It is noteworthy to mention that neuroticism alone can increase the odds of road accidents by 1.1-fold (P=0.009), but other personality factors did not have a significant effect on the equation.Conclusion: The results revealed that some mental disorders affect the incidence of road collisions. Considering the importance and sensitivity of driving behavior, it is necessary to evaluate multiple psychological factors influencing drivers before and after receiving or renewing their driver’s license.
- انتشار مقاله: 15-06-1394
- نویسندگان: Seyyed Salman Alavi,Mohammad Reza Mohammadi,Hamid Souri,Soroush Mohammadi Kalhori,Fereshteh Jannatifard,Ghazal Sepahbodi
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: Radiotherapy,Rectal Neoplasms,Human amniotic membrane,Colonic anastomosis,Anastomotic leak
- چکیده:
- چکیده انگلیسی: Background: Radiotherapy is one of the most important factors which results in negative effects on wound healing and increases anastomosis leakage. Diverting loop ileostomy has been usually performed after colorectal anastomosis in cases of colorectal cancer with a history of neoadjuvant radiotherapy to decrease the chance of leakage. Considering the side effects of diverting loop ileostomy, the objective of the present study is to investigate the effect of human amniotic membrane (HAM) on colorectal anastomosis leakage after neo-adjuvant radiotherapy. Methods: In this experimental animal study, 20 crossbreed rabbits were randomly divided into two groups (case group: 13 rabbits, control group: 7 rabbits) after receiving an equal dose of external beam radiation. Four weeks after irradiation, resection of 4 cm of colorectal segment and end-to-end single layer anastomosis were conducted. In the case group, a 2×2 cm wrap of HAM applied around the site of anastomosis. Eight weeks later, all the survived rabbits were sacrificed. A segment of anastomotic sites was resected in all expired and survived rabbits and sent for pathological evaluation. Mann-Whitney U Test (SPSS for Windows, Ver. 16, Chicago, IL) was applied to analyze healing scores between the two groups.Results: Due to anastomosis dehiscence, 5 rabbits expired in the control group, but all the 13 rabbits (case group) survived after 8 weeks and showed no leakage. In addition, pathological evaluation revealed significant epithelialization and neovascularization in the case group. Statistically, healing score was higher in the case group rather than the control group (P<0.001).Conclusion: To prevent post irradiation colorectal anastomosis leakage, the use of HAM might play a significant role and a feasible technical approach.
- انتشار مقاله: 13-04-1394
- نویسندگان: Sam Moslemi,Sajjad Ahmadi Joraghi,Reza Roshanravan,Leila Ghahramani,Mohammad Mohammadianpanah,Masood Hosseinzadeh,Abbas Rezaianzadeh,Ahmed Mohammed Ali Hussein,Neda Najibpour,Seyed Vahid Hosseini
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: Radiotherapy,Prognosis,Surgery,Thymic neoplasms
- چکیده:
- چکیده انگلیسی: Background: Thymomas are rare epithelial tumors arising from thymus gland. This study aims at investigating the clinical presentation, prognostic factors and treatment outcome of forty five patients with thymoma and thymic carcinoma. Methods: Forty-five patients being histologically diagnosed with thymoma or thymic carcinoma that were treated and followed-up at a tertiary academic hospital during January 1987 and December 2008 were selected for the present study. Twelve patients were solely treated with surgery, 14 with surgery followed by adjuvant radiotherapy, 12 with sequential combined treatment of surgery, radiotherapy and/or chemotherapy and 7 with non-surgical approach including radiotherapy and/or chemotherapy. Tumors were classified based on the new World Health Organization (WHO) histological classification. Results: There were 18 women and 27 men with a median age of 43 years. Twelve patients (26.7%) had stage I, 7 (17.8%) had stage II, 23 (51%) had stage III and 2 (4.5%) had stage IV disease. Tumors types were categorized as type A (n=4), type AB (n=10), type B1 (n=9), type B2 (n=10), type B3 (n=5) and type C (n=7). In univariate analysis for overall survival, disease stage (P=0.001), tumor size (P=0.017) and the extent of surgical resection (P<0.001) were prognostic factors. Regarding the multivariate analysis, only the extent of the surgical resection (P<0.001) was the independent prognostic factor and non-surgical treatment had a negative influence on the survival. The 5-year and 10-year overall survival rates were 70.8% and 62.9%, respectively. Conclusion: Complete surgical resection is the most important prognostic factor in patients with thymic epithelial tumors.
- انتشار مقاله: 10-04-1393
- نویسندگان: Mansour Ansari,Farzin Dehsara,Mohammad Mohammadianpanah,Ahmad Mosalaei,Shapour Omidvari,Niloofar Ahmadloo
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: Breast cancer,Radiotherapy,Hydrocortisone,Radiation-induced dermatitis
- چکیده:
- چکیده انگلیسی: Background: This two-arm, randomized clinical study aimed to compare efficacy between topical Alpha ointment and topical hydrocortisone cream (1%) in the healing of radiation-induced dermatitis in breast cancer patients. Methods: The inclusion criteria comprised newly pathologically proven, locally advanced breast cancer (treated with modified radical mastectomy followed by sequential adjuvant treatments, including chest wall radiotherapy [45-50.4 Gy]) and grade 2 and/or 3 chest wall dermatitis. The exclusion criteria were comprised of any underlying disease or medications interfering with the wound healing process, previous history of chest wall radiotherapy, and concurrent use of chemotherapy. Sixty eligible patients were randomly assigned to use either topical Alpha ointment (study arm, n=30) or topical hydrocortisone cream (1%) (control arm, n=30) immediately after receiving a total dose of 45-50 Gy chest wall radiotherapy. Results: The mean radiation dose was 49.1 Gy in the control arm and 48.8 Gy in the study arm. The mean dermatitis area was 13.54 cm2 in the control arm and 17.02 cm2 in the study arm. Topical Alpha ointment was more effective on the healing of radiation-induced dermatitis than was topical hydrocortisone cream (1%) (P=0.001). This effect was significant in the second week (P=0.007). In addition, Alpha ointment decreased the patients’ complaints such as pain (P<0.001), pruritus (P=0.009), and discharge (P=0.010) effectively and meaningfully. Conclusion: Topical Alpha ointment was more effective on the healing of radiation-induced dermatitis than was topical hydrocortisone cream (1%) in our patients with breast cancer. Trial Registration Number: IRCT201206099979N1
- انتشار مقاله: 23-06-1392
- نویسندگان: Mansour Ansari,Farzin Dehsara,Ahmad Mosalaei,Shapour Omidvari,Niloofar Ahmadloo,Mohammad Mohammadianpanah
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: WOUND HEALING,Albumin,Burn,Transferrin
- چکیده:
- چکیده انگلیسی: Background: Administration of albumin for burn patients and its effects on mortality and morbidity has been debated for along time. The aim of this study was to evaluate the effects of albumin administration on wound healing, length of hospital stay, weight change, and mortality of burn patients. Methods: Two matched groups of patients from Shiraz Burn Care Center were randomly selected. The patients in one group received parenteral albumin in addition to high protein diet and the other group received only high protein diet. The length of hospital stay, healing time, mortality, serum albumin, transferrin levels, and weight loss were compared. Results: A total of 141 patients were selected; 71 patients in control group and 70 patients in albumin group. There were no significant differences in mortality (P=0.97), length of hospital stay (P=0.45), and healing time (P=0.25) in two groups. The patients who survived had significantly higher serum transferrin level (128 mg/dL versus 102 mg/dL). Conclusion: Parenteral albumin administration did not have a significant effect on mortality, length of hospital stay, and healing time in burn patients.Trial Registration Number: IRCT138802141605N3
- انتشار مقاله: 16-12-1393
- نویسندگان: Ali Akbar Mohammadi,Mohammad Jalal Hashemi-Nasab,Reza Ershadi,Ahmad Reza Tavakkolian,Nasir Fakhar,Hamid Reza Tolide-ie,Mohammad Kazem Mohammadi
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی:
- چکیده:
- چکیده انگلیسی: Background: Burns are among the most common traumas in developing countries, which consume large amounts of medical resources. It is important to find an appropriate material for dressing of burn wounds that improves healing and is readily available, easily applicable, and economical. Methods: In a single-blind randomized controlled clinical trial from March to October 2006, 211 patients with less than 20% burn were enrolled into two groups. The first group contained 104 patients with average burn of 11.90± 3.80% of total body surface area (TBSA) for whom amnion dressing was used. The second group composed of 107 patients with average burn of 12.30± 4.14% of TBSA treated with routine silver sulfadiazine dressing. Results: Amniotic membrane usage was accompanied by acceleration in wound healing, less need for skin graft, and less pain. The mean healing time in superficial parts of burn wounds in the amnion group was significantly shorter than the control group (9.50±2.13 v 14.30±2.60 days; P value < 0.01). The extent of the wound with granulation tissue which needed skin graft was less in the amnion group (2.10 ± 2.21% v 4.2 0±1.44%; P value < 0.01). Conclusion: Widespread use of amniotic membrane dressing is recommended for limited burn wound management.
- انتشار مقاله: 22-02-1394
- نویسندگان: Ali Akbar Mohammadi,Babak Sabet,Hooman Riazi,Ahmad Reza Tavakko-lian,Mohammad Kazem Mohammadi,Soraya Iranpak
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Immunology
- نوع مقاله: Journal Article
- کلمات کلیدی: Cytokines,Major Depression,Immunoglobulin
- چکیده:
- چکیده انگلیسی: Background: Major Depression Disorder (MDD) is a common disorder with preva-lence of 15% among men and up to 25% among women. In recent years the association of immune system alterations and MDD has been investigated. Assessments of immu-nologic and inflammatory responses in these patients enhance our knowledge of the eti-ology and pathogenesis of this disease.
Objective: To investigate the changes in immu-noglobulin and cytokine serum levels and lymphocyte subsets in patients with MDD.
Methods: We studied 37 adult patients with MDD, diagnosed based on DSM-IV diag-nostic criteria, and 15 healthy controls matched with the patients. Plasma concentration of interleukin-4 (IL-4), IL-10, TNF α, and IFN γ were measured by ELISA and serum immunoglobulins by SRID. Total number of NK cells (CD16 and CD56), B cells (CD19), and T cells (CD8, CD4, and CD3) were determined by flow cytometry.
Results: We found no significant differences in plasma concentration of IL-4, IL-10, TNF-α, IFN-γ, and immunoglobulins as well as total number of NK cells, B cells, and T cells between major depressed patients and healthy control subjects.
Conclusion: We conclude that in our patients, there were no significant differences in immune system ac-tivity between MDD patients and controls.- انتشار مقاله: 17-05-1395
- نویسندگان: Reza Farid Hosseini,Farahzad Jabbari Azad,Ali Talaee,Sara Miri,Naghme Mokhber,Farhad Farid Hosseini,Habibollah Esmaeili,Mahmoud Mahmoudi,Hoshang Rafatpanah,Mohammadreza Mohammadi
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Finance
- نوع مقاله: Journal Article
- کلمات کلیدی: Strategic Management Accounting Techniques,Consequences of Green Accounting,Analysis CARD,Developed Theory of Rough
- چکیده:
- چکیده انگلیسی: Strategic management accounting, including systems and processes in the modern era, is characterized by changes in the competitive environment that, Can be achieved through the participation of companies in the management accounting system, Assist financial managers to make decisions in the value chain and develop green accounting functions. Unfortunately, though, over time, strategic management accounting techniques are still unknown to corporate executives, especially in environmental processes, leading to a decline in corporate participation in strategic decision making. The Purpose of this research is Capacity Building Green Accounting Consequences Based on Explanation of Strategic Management Accounting Techniques by analysis of CARD and developed the theory of Rough (ERST). The methodology of this research is developmental, applied and hybrid and two groups of target population participated in this research. In the first part of 15 experts in the field of accounting at the university level an In the second part, 35 executives participated matrix Tehran Stock Exchange through a questionnaire that both the target population, sampling was homogenous. In this research, in the qualitative part, the components and indices related to the research variables were selected based on content analysis and cross-analysis and then based on Delphi analysis and hierarchical analysis in order to achieve theoretical adequacy. Then, in the quantitative section, through the analysis of the Rough Complex analysis, the decision tree determined the most effective green accounting function/outcome and strategic management accounting technique, and finally, the product life cycle costing technique is the most effective strategic management accounting technique for enhancing green accounting functions. In fact, the results showed that product cycle costing technique is a factor for enhancing the cost savings of recycling and waste recycling costs and increasing the competitiveness of the company as a component of green accounting competitive Consequences.
- انتشار مقاله: 25-01-1399
- نویسندگان: Behjat Abbasi,Mohammadhamed Khanmohammadi,Zahra Moradi,Tahereh Mahmoodiyan
- مشاهده